Minna Piipponen
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View article: Adipose tissue-derived fibroblasts engage in immune-stromal crosstalk during obesity-aggravated atherosclerosis in mice
Adipose tissue-derived fibroblasts engage in immune-stromal crosstalk during obesity-aggravated atherosclerosis in mice Open
Background Atherosclerosis is a common disorder where changes in vascular wall and in the surrounding perivascular adipose tissue are evident. However, how multiple cell types contribute to the disease at the cellular level remains poorly …
View article: Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair (Adv. Sci. 25/2025)
Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair (Adv. Sci. 25/2025) Open
View article: Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair
Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair Open
The discovery of an increasing number of translatable circular RNAs (circRNAs) raises the question of whether their coding and non‐coding functions can coexist within the same cell. This study profiles the dynamic expression of circRNAs du…
View article: Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors
Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors Open
View article: Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing
Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing Open
Background Skin wound healing involves a complex gene expression programme that remains largely undiscovered in humans. Circular RNAs (circRNAs) and microRNAs (miRNAs) are key players in this process. Objectives To understand the functions…
View article: The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing
The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing Open
View article: Clustering of RNA co-expression network identifies novel long non-coding RNA biomarkers in squamous cell carcinoma
Clustering of RNA co-expression network identifies novel long non-coding RNA biomarkers in squamous cell carcinoma Open
Long non-coding RNAs (lncRNAs) have emerged as important players in cancer progression. Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer with increasing incidence worldwide. The prognosis of the metastatic…
View article: Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing
Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing Open
Summary Both circular RNAs (circRNA) and microRNAs (miRNA) have emerged to play important roles in health and disease. To understand their function in tissue repair, we profiled circRNA, linear RNA, and miRNA expression dynamics in human w…
View article: The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing
The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing Open
The cell transitionfrom an inflammatory phase to a subsequent proliferative phase is crucial for wound healing, yet the driving mechanism remains unclear. By profiling lncRNA expression changesduring human skin wound healing and screening …
View article: Clustering of RNA co-expression network identifies novel long non-coding RNA biomarkers in squamous cell carcinoma
Clustering of RNA co-expression network identifies novel long non-coding RNA biomarkers in squamous cell carcinoma Open
Long non-coding RNAs (lncRNAs) have been shown to play an important role in cancer progression. Cutaneous squamous cell carcinoma is the most common metastatic skin cancer with increasing incidence worldwide. The prognosis of the metastati…
View article: Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors
Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors Open
Long-term toxicities caused by cancer treatments have recently gained increasing recognition due to a steadily growing population of cancer survivors. Radiotherapy (RT) is a common treatment known to unintentionally harm surrounding normal…
View article: Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport
Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport Open
After a skin injury, keratinocytes switch from a state of homeostasis to one of regeneration leading to the reconstruction of the epidermal barrier. The regulatory mechanism of gene expression underpinning this key switch during human skin…
View article: 592 Epigenetic memory of radiation injury in skin fibroblasts of cancer patients
592 Epigenetic memory of radiation injury in skin fibroblasts of cancer patients Open
View article: 465 Super enhancer regulated LINC00094 upregulates the expression of metalloproteinases MMP-1 and MMP-13 and promotes invasion of cutaneous squamous cell carcinoma
465 Super enhancer regulated LINC00094 upregulates the expression of metalloproteinases MMP-1 and MMP-13 and promotes invasion of cutaneous squamous cell carcinoma Open
View article: The injury-induced circular RNA circGLIS3 activates dermal fibroblasts to promote wound healing
The injury-induced circular RNA circGLIS3 activates dermal fibroblasts to promote wound healing Open
Delayed skin wound healing and excessive scarring are consequences of an impaired healing process and represent a major health and economic burden worldwide. Current intervention strategies lack efficacy and suffer from high recurrence rat…
View article: Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma
Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma Open
Long non-coding RNAs (lncRNAs) have emerged as important regulators of cancer progression. Super enhancers (SE) play a role in tumorigenesis and regulate the expression of specific lncRNAs. We examined the role of BRD3OS, also named LINC00…
View article: Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport
Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport Open
After a skin injury, keratinocytes switch from a state of homeostasis to one of regeneration leading to the reconstruction of the epidermal barrier. The regulatory mechanism of gene expression underpinning this key switch during human skin…
View article: Human skin specific long noncoding RNA <i>HOXC13-AS</i> regulates epidermal differentiation by interfering with Golgi-ER retrograde transport
Human skin specific long noncoding RNA <i>HOXC13-AS</i> regulates epidermal differentiation by interfering with Golgi-ER retrograde transport Open
After a skin injury, keratinocytes switch from a state of homeostasis to one of regeneration leading to the reconstruction of the epidermal barrier. The regulatory mechanism of gene expression underpinning this key switch during human skin…
View article: 351 The circular RNA circGLIS3 activates dermal fibroblasts and increases ECM production to improve wound healing
351 The circular RNA circGLIS3 activates dermal fibroblasts and increases ECM production to improve wound healing Open
View article: The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma
The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma Open
Skin cancers are the most common types of cancer worldwide, and their incidence is increasing. Melanoma, basal cell carcinoma (BCC), and cutaneous squamous cell carcinoma (cSCC) are the three major types of skin cancer. Melanoma originates…
View article: Complement factor I upregulates expression of matrix metalloproteinase‐13 and ‐2 and promotes invasion of cutaneous squamous carcinoma cells
Complement factor I upregulates expression of matrix metalloproteinase‐13 and ‐2 and promotes invasion of cutaneous squamous carcinoma cells Open
The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing globally. Here, we have studied the functional role of complement factor I (CFI) in the progression of cSCC. CFI was knocked down in cSCC cells, and RNA‐seq analysis w…
View article: Informal practices and the rule of law
Informal practices and the rule of law Open
When the border between the Russian Federation (hereafter, Russia) and Norway and later between Russia and Finland 'opened' during the 'migration crisis' of 2015 and 2016, the so-called Arctic route through Moscow and Northern Russia emerg…
View article: The Immune Functions of Keratinocytes in Skin Wound Healing
The Immune Functions of Keratinocytes in Skin Wound Healing Open
As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair not only as structural cells but also exerting important immune functions. This review focuses on the communications between keratinocytes and im…
View article: Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas
Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas Open
View article: Tuotettuja mielikuvia ja Idäntutkimusta VIETSin kevätseminaarissa 2019
Tuotettuja mielikuvia ja Idäntutkimusta VIETSin kevätseminaarissa 2019 Open
View article: Afrikkalainen muuttoliike, turvallisuus ja Venäjä
Afrikkalainen muuttoliike, turvallisuus ja Venäjä Open
Vuosina 2015–2016 Suomeen tuli yli 30 000 turvapaikanhakijaa erityisesti Lähi-Idästä ja eri Aasian ja Afrikan maista. Pieni osa heistä tuli niin sanottua arktista reittiä Pohjois-Venäjältä. Heistä neljäsosa oli Venäjällä asuneita maahanmuu…
View article: p53-regulated long non-coding RNA PRECSIT promotes progression of cutaneous squamous cell carcinoma via STAT3 signaling
p53-regulated long non-coding RNA PRECSIT promotes progression of cutaneous squamous cell carcinoma via STAT3 signaling Open
Long non-coding RNAs (lncRNAs) have emerged as putative biomarkers and therapeutic targets in cancer. Here, we have examined the role of LINC00346 in keratinocyte-derived cutaneous squamous cell carcinoma (cSCC). LINC00346 expression was u…
View article: 503 p53-regulated long non-coding RNA PRECSIT promotes progression of cutaneous squamous cell carcinoma via STAT3 signaling
503 p53-regulated long non-coding RNA PRECSIT promotes progression of cutaneous squamous cell carcinoma via STAT3 signaling Open
View article: Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression
Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression Open
Long non-coding RNAs (lncRNAs) regulate various cellular processes, and they have emerged as potential biomarkers and therapeutic targets in cancer. We have previously characterized the oncogenic role of lncRNA PICSAR (p38 inhibited cutane…
View article: Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma
Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma Open
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal …