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View article: Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease
Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease Open
View article: Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism
Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism Open
Background Tear fluid (TF) is a protein-rich solution that reflects pathophysiological changes in Alzheimer's disease (AD). Objective In this study, we examined whether TF proteins were differently expressed in persons with mild AD dementi…
View article: Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus
Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus Open
Background: The gut microbiome is a complex system within the human gastrointestinal tract. The bacteria play a significant role in human health, and some can promote inflammation and pathologic processes through chemical interactions or m…
View article: Association between the estimated 10‐year cardiovascular mortality risk and cognitive function in older adults: results from the FINGER trial
Association between the estimated 10‐year cardiovascular mortality risk and cognitive function in older adults: results from the FINGER trial Open
Background Dementia risk scores could be instrumental in the implementation of multidomain lifestyle interventions for dementia prevention. However, as relatively new tools, their performance requires further validation. Given the extensiv…
View article: Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired
Computer-based Eye-tracking Analysis of King-Devick Test Differentiates Persons With Idiopathic Normal Pressure Hydrocephalus From Cognitively Unimpaired Open
Background: Functional defects in eye movements and reduced reading speed in neurodegenerative diseases represent a potential new biomarker to support clinical diagnosis. We investigated whether computer-based eye-tracking (ET) analysis of…
View article: Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease
Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer’s Disease Open
Background: Wide-ranging functional defects in eye movements have been reported in Alzheimer’s disease (AD) dementia. The detection of abnormal eye movements and reading problems may identify persons at risk of AD when clear clinical sympt…
View article: Pet ownership supports quality of life in home‐dwelling people with Alzheimer's disease
Pet ownership supports quality of life in home‐dwelling people with Alzheimer's disease Open
Objectives Human‐animal interactions have beneficial psychosocial and psychophysiological effects on individuals in both the presence and absence of medical health conditions. No previous prospective studies with long follow‐up have invest…
View article: Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial
Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial Open
Aims Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effec…
View article: Smoking, pulmonary and heart diseases and the risk of cognitive impairment and dementia : an epidemiological approach
Smoking, pulmonary and heart diseases and the risk of cognitive impairment and dementia : an epidemiological approach Open
View article: Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol Open
View article: Prospective Ultrasound Screening of Men With Cerebrovascular Disease for Abdominal Aortic Aneurysms
Prospective Ultrasound Screening of Men With Cerebrovascular Disease for Abdominal Aortic Aneurysms Open
Background: The prevalence of abdominal aortic aneurysms is higher in population with other vascular comorbidities, especially among men. Utility of screening among patients with cerebrovascular disease is unclear. Objective: To determine …
View article: Late‐life personality traits, cognitive impairment, and mortality in a population‐based cohort
Late‐life personality traits, cognitive impairment, and mortality in a population‐based cohort Open
Objectives We examined longitudinal associations between late‐life personality traits and cognitive impairment, dementia, and mortality in the population‐based Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Study. Methods Anger ex…
View article: Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+study protocol
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+study protocol Open
\n\nBackground\nThe oldest old is the fastest growing age group worldwide and the most prone to severe disability, especially in relation to loss of cognitive function. Improving our understanding of the predictors of cognitive, physical a…
View article: Long‐term dementia risk prediction by the LIBRA score: A 30‐year follow‐up of the CAIDE study
Long‐term dementia risk prediction by the LIBRA score: A 30‐year follow‐up of the CAIDE study Open
Objective As no causal treatment for dementia is available yet, the focus of dementia research is slowly shifting towards prevention strategies. Therefore, this study aimed to examine the predictive accuracy of the “LIfestyle for BRAin Hea…
View article: Serum Insulin and Cognitive Performance in Older Adults: A Longitudinal Study
Serum Insulin and Cognitive Performance in Older Adults: A Longitudinal Study Open
View article: Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial
Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial Open
View article: Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial
Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial Open
Introduction The 2‐year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated wheth…