Minoarisoa Rajerison
YOU?
Author Swipe
View article: Evidence of populational Burkholderia pseudomallei exposure in Madagascar
Evidence of populational Burkholderia pseudomallei exposure in Madagascar Open
Background Burkholderia pseudomallei (Bp), the causative agent of melioidosis, poses a significant health risk in endemic regions. This study aimed to characterize six previously identified Bp antigens for exposure monitoring in potential …
View article: First assessment of plague in terrestrial small mammals and fleas from Makira Natural Park and surroundings, North-eastern Madagascar
First assessment of plague in terrestrial small mammals and fleas from Makira Natural Park and surroundings, North-eastern Madagascar Open
Background Plague, a zoonosis caused by Yersinia pestis , is endemic in Madagascar but knowledge on the epidemiological situation in the northern focus remains unclear. The aim of this study was to investigate the circulation of Y. pestis …
View article: Investigating the overlap between the unexplored T and B cell repertoires in patients having survived a Yersinia pestis infection 3528
Investigating the overlap between the unexplored T and B cell repertoires in patients having survived a Yersinia pestis infection 3528 Open
Description Yersinia pestis, the pathogen behind devastating plague epidemics, manifests in bubonic and pneumonic forms. Pneumonic plague has a 60% mortality rate even with prompt treatment, underscoring its potential as a bioweapon. Despi…
View article: Genetic structure of <i>Rattus rattus</i> populations in an endemic plague focus in Madagascar: implications for rodent surveillance and management
Genetic structure of <i>Rattus rattus</i> populations in an endemic plague focus in Madagascar: implications for rodent surveillance and management Open
Background: Plague remains a major public health concern in Madagascar. In the Central Highlands, where the disease is still endemic, the black rat ( Rattus rattus in reservoir of the causative agent Yersinia pestis . Understanding its pop…
View article: <i>Angiostrongylus cantonensis</i> Lungworms in Definitive and Intermediate Hosts, Madagascar, 2024
<i>Angiostrongylus cantonensis</i> Lungworms in Definitive and Intermediate Hosts, Madagascar, 2024 Open
We assessed the prevalence of the rat lungworm, Angiostrongylus cantonensis, in rats and snails in Toamasina, Madagascar, using molecular techniques. Although no human cases of neuroangiostrongyliasis have been reported in Madagascar, the …
View article: Ciprofloxacin versus Aminoglycoside–Ciprofloxacin for Bubonic Plague
Ciprofloxacin versus Aminoglycoside–Ciprofloxacin for Bubonic Plague Open
Oral ciprofloxacin monotherapy for 10 days was noninferior to an aminoglycoside-ciprofloxacin sequential combination for the treatment of patients with bubonic plague. (Funded by the U.K. Foreign, Commonwealth, and Development Office and W…
View article: Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar
Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar Open
Background The plague, caused by Yersinia pestis , remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid and accurate detection of this pathogen is essential for effective outbreak management and ti…
View article: IgG antibodies anti-LcrV of Yersinia pestis: inconsistent responses in confirmed plague patients from Madagascar
IgG antibodies anti-LcrV of Yersinia pestis: inconsistent responses in confirmed plague patients from Madagascar Open
Objective Plague (Yersinia pestis infection) is a flea-borne zoonotic disease mainly affecting African countries, with most human cases reported from Madagascar and the Democratic Republic of Congo. Although curable, plague can be fatal wi…
View article: Unraveling the role of rat and flea population dynamics on the seasonality of plague epidemics in Madagascar
Unraveling the role of rat and flea population dynamics on the seasonality of plague epidemics in Madagascar Open
Plague continues to pose a public health problem in multiple regions of the world, including Madagascar, where it is characterized by a pronounced seasonal pattern. The drivers of plague seasonality remain poorly understood. Using a determ…
View article: Community-led intensive trapping reduces abundance of key plague reservoir and flea vector
Community-led intensive trapping reduces abundance of key plague reservoir and flea vector Open
Background Zoonotic pathogens transmitted by rodents are highly prevalent in low-middle income countries and effective control measures that are easily implemented are urgently needed. Whilst rodent control seems sensible as a mitigation s…
View article: Climatic variations and Yersinia pestis host-vector abundance: a case study in Ankazobe district to understand plague epidemiology in Madagascar
Climatic variations and Yersinia pestis host-vector abundance: a case study in Ankazobe district to understand plague epidemiology in Madagascar Open
View article: IgG antibodies anti-LcrV of Yersinia pestis: inconsistent responses in confirmed plague patients from Madagascar
IgG antibodies anti-LcrV of Yersinia pestis: inconsistent responses in confirmed plague patients from Madagascar Open
Objective: Plague (Yersinia pestis infection) is a flea-borne zoonotic disease mainly affecting African countries, with most human cases reported from Madagascar and the Democratic Republic of Congo. Although curable, plague can be fatal w…
View article: Assessing the threat of <i>Yersinia pestis</i> harboring a multi-resistant IncC plasmid and the efficacy of an antibiotic targeting LpxC
Assessing the threat of <i>Yersinia pestis</i> harboring a multi-resistant IncC plasmid and the efficacy of an antibiotic targeting LpxC Open
Self-transmissible IncC plasmids rapidly spread multidrug resistance in many medically important pathogens worldwide. A large plasmid of this type (pIP1202, ~80 Kb) has been isolated in a clinical isolate of Yersinia pestis , the agent of …
View article: Rodent-Borne Parasites in Ankazobe, Central Highlands of Madagascar: Impact of Surveillance on Neglected Zoonotic Diseases
Rodent-Borne Parasites in Ankazobe, Central Highlands of Madagascar: Impact of Surveillance on Neglected Zoonotic Diseases Open
View article: Risques sanitaires associés à l'exploitation de la viande de brousse autour du parc naturel Makira
Risques sanitaires associés à l'exploitation de la viande de brousse autour du parc naturel Makira Open
Risques sanitaires associés à l’exploitation de la viande de brousse autour du parc naturel Makira La chasse et la consommation de viande de brousse peuvent faciliter la transmission d'agents pathogènes zoonotiques entre la faune sauvage e…
View article: Global evolutionary patterns of<i>Yersinia pestis</i>and its spread into Africa
Global evolutionary patterns of<i>Yersinia pestis</i>and its spread into Africa Open
The zoonotic pathogen Yersinia pestis , the etiologic agent of plague, has caused three major pandemics and diversified in different lineages currently established in endemic areas worldwide 1–3 . However, some regions like continental Afr…
View article: Impact of Sanitation on Rodent Pullulation and Plague Status in an Informal Settlement on the Outskirts of Mahajanga (Madagascar)
Impact of Sanitation on Rodent Pullulation and Plague Status in an Informal Settlement on the Outskirts of Mahajanga (Madagascar) Open
Plague is a zoonotic disease caused by Yersinia pestis, and it is endemic in Madagascar. The plague cycle involves wild and commensal rodents and their fleas; humans are an accidental host. Madagascar is the country where plague burden is …
View article: An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus an aminoglycoside + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial—an update to the published protocol
An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus an aminoglycoside + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial—an update to the published protocol Open
View article: Review of genotyping methods for Yersinia pestis in Madagascar
Review of genotyping methods for Yersinia pestis in Madagascar Open
Background Plague, a zoonotic disease caused by Yersinia pestis , was responsible for 3 historical human pandemics that killed millions of people. It remains endemic in rodent populations in Africa, Asia, North America, and South America b…
View article: Multiple Introductions of <i>Yersinia pestis</i> during Urban Pneumonic Plague Epidemic, Madagascar, 2017
Multiple Introductions of <i>Yersinia pestis</i> during Urban Pneumonic Plague Epidemic, Madagascar, 2017 Open
Pneumonic plague (PP) is characterized by high infection rate, person-to-person transmission, and rapid progression to severe disease. In 2017, a PP epidemic occurred in 2 Madagascar urban areas, Antananarivo and Toamasina. We used epidemi…
View article: Assessing the effectiveness of intervention to prevent plague through community and animal-based survey
Assessing the effectiveness of intervention to prevent plague through community and animal-based survey Open
Bubonic plague, transmitted by infected flea bites, is the most common form of plague and, left untreated, can progress to the pneumonic form, which is highly contagious. Surveillance focusing on reservoir and vector is considered to be th…
View article: The surveillance of plague among rodents and dogs in Western Iran
The surveillance of plague among rodents and dogs in Western Iran Open
Background The causative agent of plague, Yersinia pestis , is maintained in nature via a flea-rodent cycle. Western Iran is an old focus for plague, and recent data indicate that rodents and dogs in this region have serological evidence o…
View article: A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague
A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague Open
Mice were immunized with a combination of self-amplifying (sa) RNA constructs for the F1 and V antigens of Yersinia pestis at a dose level of 1 μg or 5 μg or with the respective protein sub-units as a reference vaccine. The immunization of…
View article: Knockdown resistance mutations are common and widely distributed in Xenopsylla cheopis fleas that transmit plague in Madagascar
Knockdown resistance mutations are common and widely distributed in Xenopsylla cheopis fleas that transmit plague in Madagascar Open
Background Plague, caused by the bacterium Yersinia pestis , remains an important disease in Madagascar, where the oriental rat flea, Xenopsylla cheopis , is a primary vector. To control fleas, synthetic pyrethroids (SPs) have been used fo…
View article: Reproductive ecology of the black rat (<i>Rattus rattus</i>) in Madagascar: the influence of density‐dependent and ‐independent effects
Reproductive ecology of the black rat (<i>Rattus rattus</i>) in Madagascar: the influence of density‐dependent and ‐independent effects Open
The black rat ( Rattus rattus ) poses a severe threat to food security and public health in Madagascar, where it is a major cause of pre‐ and post‐harvest crop losses and an important reservoir for many zoonotic diseases, including plague.…
View article: Phylogenetic analysis of the origin and spread of plague in Madagascar
Phylogenetic analysis of the origin and spread of plague in Madagascar Open
Background Plague is a zoonotic disease caused by the bacterium Yersinia pestis , highly prevalent in the Central Highlands, a mountainous region in the center of Madagascar. After a plague-free period of over 60 years in the northwestern …
View article: Living with rodent pests: Unifying stakeholder interests to prioritise pest management in rural Madagascar
Living with rodent pests: Unifying stakeholder interests to prioritise pest management in rural Madagascar Open
Rodent pests can have major social, economic, and environmental impacts. Their management, therefore, represents a complex socio‐ecological problem involving a network of stakeholders from across different sectors, with diverging and somet…
View article: Analytical framework to evaluate and optimize the use of imperfect diagnostics to inform outbreak response: Application to the 2017 plague epidemic in Madagascar
Analytical framework to evaluate and optimize the use of imperfect diagnostics to inform outbreak response: Application to the 2017 plague epidemic in Madagascar Open
During outbreaks, the lack of diagnostic “gold standard” can mask the true burden of infection in the population and hamper the allocation of resources required for control. Here, we present an analytical framework to evaluate and optimize…
View article: Plague in Tanzania: first report of sylvatic plague in Morogoro region, persistence in Mbulu focus, and ongoing quiescence in Lushoto and Iringa foci
Plague in Tanzania: first report of sylvatic plague in Morogoro region, persistence in Mbulu focus, and ongoing quiescence in Lushoto and Iringa foci Open
These results provide evidence of the circulation of Y. pestis in small mammals in Tanzania. Furthermore, evidence of the circulation of Y. pestis in Morogoro-Mvomero highlights the importance of carrying out plague surveilla…
View article: Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017 Open