Min‐Ok Ryu
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View article: Delineating the fecal microbiome of healthy domestic short-hair cats in South Korea
Delineating the fecal microbiome of healthy domestic short-hair cats in South Korea Open
Background The gut microbiome is a vital component of an organism’s health, influencing metabolism, immune function, and overall homeostasis. In this study, we aimed to characterize the gut microbiota of healthy domestic short-hair cats in…
View article: Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs
Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs Open
Aging leads to increased disease susceptibility and weakened immunity, a condition known as immunosenescence. The growth hormone-releasing hormone (GHRH)/growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis plays a key role in bot…
View article: Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with fenbendazole
Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with fenbendazole Open
Introduction Abemaciclib, a CDK4/6 inhibitor, is well-established for treating hormone receptor-positive and HER2-negative (HR + /HER2 − ) human breast cancer by inducing G1 cell cycle arrest. However, its antitumor effects in other cancer…
View article: Deep learning-based evaluation of the severity of mitral regurgitation in canine myxomatous mitral valve disease patients using digital stethoscope recordings
Deep learning-based evaluation of the severity of mitral regurgitation in canine myxomatous mitral valve disease patients using digital stethoscope recordings Open
Background Myxomatous mitral valve disease (MMVD) represents the most prevalent cardiac disorder in dogs, frequently resulting in mitral regurgitation (MR) and congestive heart failure. Although echocardiography is the gold standard for di…
View article: Auranofin Induces <scp>ER</scp> Stress‐Mediated Apoptosis, and Its Combination With Bortezomib Elicits Paraptosis‐Like Cell Death in Malignant Canine Mammary Tumour Cells
Auranofin Induces <span>ER</span> Stress‐Mediated Apoptosis, and Its Combination With Bortezomib Elicits Paraptosis‐Like Cell Death in Malignant Canine Mammary Tumour Cells Open
Canine mammary tumours (CMT) are common in female dogs, often associated with malignancy and limited responses to conventional therapies. This study explores the potential of Auranofin (AF) in malignant CMT, focusing on its ability to indu…
View article: Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture
Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture Open
Introduction Mesenchymal stem cells (MSCs) have been introduced as a treatment for dogs owing to their immunomodulatory effects. In humans, 3D-cultured MSCs have recently been applied in treating various conditions, including myocardial in…
View article: A rare case of acute erythroid leukemia (AML M6-Er) with pleural metastasis and malignant pleural effusion in a cat
A rare case of acute erythroid leukemia (AML M6-Er) with pleural metastasis and malignant pleural effusion in a cat Open
An 11-year-old castrated male Turkish Angora cat presented with chronic lethargy and inappetence was diagnosed with non-regenerative anemia, increased nucleated red blood cells, and thrombocytopenia. Tests for anemia-related infections wer…
View article: Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase <scp>A</scp> autoantibody, and <scp>C‐reactive protein</scp> for early detection of malignant tumors in dogs
Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase <span>A</span> autoantibody, and <span>C‐reactive protein</span> for early detection of malignant tumors in dogs Open
Background Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in‐house method has not been established. Objectives To investigate the most optimal model by combining thymidine kinase 1 (…
View article: Clinical Outcome of Multicentric Lymphoma Treated with Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone (CHOP) in Small Breed Dogs
Clinical Outcome of Multicentric Lymphoma Treated with Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone (CHOP) in Small Breed Dogs Open
Lymphoma is one of the most common malignant tumors in dogs. Combination chemotherapy with vincristine, cyclophosphamide, doxorubicin, and prednisolone (CHOP) is the most effective treatment for multicentric lymphoma. Previous studies have…
View article: Evaluation serum soluble interleukin 2 receptor with diagnosis and prognosis in canine solid tumour: 34 cases
Evaluation serum soluble interleukin 2 receptor with diagnosis and prognosis in canine solid tumour: 34 cases Open
Background/Aim The soluble interleukin‐2 receptor (sIL‐2R) serve as a valuable biomarker for tumors in human patients, as its levels increase during the activation of T lymphocytes in clinical states such as inflammation, infection, and tu…
View article: A retrospective study of tracheal collapse in small-breed dogs: 110 cases (2022–2024)
A retrospective study of tracheal collapse in small-breed dogs: 110 cases (2022–2024) Open
Background The grade of tracheal collapse (TC) is assessed by the diameter of the narrowed lumen. However, studies on the relationship between TC grade and clinical symptom severity are lacking. Objectives To investigate the clinical chara…
View article: Pirfenidone inhibits TGF-β1-induced fibrosis via downregulation of Smad and ERK pathway in MDCK cells
Pirfenidone inhibits TGF-β1-induced fibrosis via downregulation of Smad and ERK pathway in MDCK cells Open
The prevalence of chronic kidney disease (CKD) in dogs increases with age, and renal fibrosis is an important pathophysiological mechanism in this process. However, only a few drugs that can effectively inhibit fibrosis in the kidneys of d…
View article: Blood Neutrophil‐to‐Lymphocyte Ratio as a Potential Prognostic Marker in Dogs ≤10 kg With Multicentric Lymphoma
Blood Neutrophil‐to‐Lymphocyte Ratio as a Potential Prognostic Marker in Dogs ≤10 kg With Multicentric Lymphoma Open
Canine lymphoma, the most prevalent haematopoietic tumour in dogs, presents significant challenges in veterinary oncology. This study investigates the prognostic value of the neutrophil‐to‐lymphocyte ratio (NLR) in small‐sized dogs (≤10 kg…
View article: Pirfenidone inhibits TGF-β1-induced fibrosis via downregulation of Smad and ERK pathway in MDCK cells
Pirfenidone inhibits TGF-β1-induced fibrosis via downregulation of Smad and ERK pathway in MDCK cells Open
The prevalence of chronic kidney disease (CKD) in dogs increases with age, and renal fibrosis is an important pathophysiological mechanism in this process. However, only a few drugs that can effectively inhibit fibrosis in the kidneys of d…
View article: Romiplostim for treatment of thrombocytopenia in dogs: A retrospective assessment and clinical outcomes
Romiplostim for treatment of thrombocytopenia in dogs: A retrospective assessment and clinical outcomes Open
Background Romiplostim, a thrombopoietin analog, is commonly used to treat immune‐mediated thrombocytopenia (ITP) in humans, but its use in dogs remains limited. Objectives Evaluate the effects and adverse events of romiplostim administrat…
View article: Oxidative hemolytic crises in a dog due to fragrance products: clinical insights and treatment approaches
Oxidative hemolytic crises in a dog due to fragrance products: clinical insights and treatment approaches Open
Recurring oxidative hemolytic crises should raise suspicions of environmental toxicity, which, although harmless in small quantities to humans, can be devastating to small-breed dogs. In addition to removing the causative agents, methylene…
View article: Serum thymidine kinase 1 protein concentrations and presence of its autoantibody as biomarkers for screening dogs with malignant tumors
Serum thymidine kinase 1 protein concentrations and presence of its autoantibody as biomarkers for screening dogs with malignant tumors Open
Background An accurate and easily accessible method for diagnosing malignancies in local veterinary clinics has not yet been established. Objectives To investigate the usefulness of serum thymidine kinase 1 (TK1) protein and its autoantibo…
View article: Peritoneal carcinomatosis with desmoplasia and osseous metaplasia mimicking encapsulating peritoneal sclerosis in a cat: case report
Peritoneal carcinomatosis with desmoplasia and osseous metaplasia mimicking encapsulating peritoneal sclerosis in a cat: case report Open
A 13-year-old neutered male Korean short-hair cat presented with anorexia, lethargy, and a severely distended abdomen, suggestive of ascites. Abdominocentesis yielded serosanguineous fluid. A subsequent diagnostic workup, including blood t…
View article: Palmar–plantar erythrodysesthesia syndrome resulting from toceranib phosphate in a dog with apocrine gland anal sac adenocarcinoma: a case report
Palmar–plantar erythrodysesthesia syndrome resulting from toceranib phosphate in a dog with apocrine gland anal sac adenocarcinoma: a case report Open
An 11-year-old neutered male Miniature Poodle with a stage 3 apocrine gland adenocarcinoma was started on chemotherapy with toceranib phosphate after surgery. Beginning on day 10 of toceranib, the dog's foot pads became erythematous and hy…
View article: TSG-6 in extracellular vesicles from canine mesenchymal stem/stromal is a major factor in relieving DSS-induced colitis
TSG-6 in extracellular vesicles from canine mesenchymal stem/stromal is a major factor in relieving DSS-induced colitis Open
Adipose tissue derived mesenchymal stem/stromal cell (ASC)-derived extracellular vesicles (EV) have been reported to be beneficial against dextran sulfate sodium (DSS)-induced colitis in mice. However, the underlying mechanisms have not be…
View article: TSG-6 in extracellular vesicles from canine mesenchymal stem/stromal is a major factor in relieving DSS-induced colitis
TSG-6 in extracellular vesicles from canine mesenchymal stem/stromal is a major factor in relieving DSS-induced colitis Open
Mesenchymal stem/stromal cell (MSC)-derived extracellular vesicles (EV) have been reported to be beneficial against dextran sulfate sodium (DSS)-induced colitis in mice. However, the underlying mechanisms have not been fully elucidated. We…
View article: Enhanced angiogenic activity of dimethyloxalylglycine-treated canine adipose tissue-derived mesenchymal stem cells
Enhanced angiogenic activity of dimethyloxalylglycine-treated canine adipose tissue-derived mesenchymal stem cells Open
The paracrine function of mesenchymal stem cells (MSCs) during transplantation has been recently studied due to its poor differentiation ratio. Dimethyloxalylglycine (DMOG) has been used to promote angiogenesis in experimental animal model…
View article: Extracellular cyclic adenosine monophosphate‐dependent protein kinase A autoantibody and C‐reactive protein as serum biomarkers for diagnosis of cancer in dogs
Extracellular cyclic adenosine monophosphate‐dependent protein kinase A autoantibody and C‐reactive protein as serum biomarkers for diagnosis of cancer in dogs Open
Protein kinase A, a cyclic adenosine monophosphate (AMP)‐dependent enzyme, normally exists within mammalian cells; however, in cancer cells, it can leak out and be found in the serum. Extracellular cyclic AMP‐dependent protein kinase A (EC…