Philip D. Minor
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View article: Improving promptness and quality of hospitalist‐consultant interactions at an academic teaching hospital
Improving promptness and quality of hospitalist‐consultant interactions at an academic teaching hospital Open
Communication between consulting and consultant services is essential to provide high‐value care. We implemented a collaborative project between hospital medicine (HM), emergency medicine (EM), and departmental leadership of the major cons…
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View article: WHO working group meeting to amend WHO Recommendations to assure the quality, safety and efficacy of live attenuated yellow fever vaccines
WHO working group meeting to amend WHO Recommendations to assure the quality, safety and efficacy of live attenuated yellow fever vaccines Open
The current WHO Recommendations to assure the quality, safety and efficacy of live attenuated yellow fever vaccines were adopted in 2010. This document recommends that vaccine virus master and working seed lots should be tested for viscero…
View article: WHO International Standard for evaluation of the antibody response to COVID-19 vaccines: call for urgent action by the scientific community
WHO International Standard for evaluation of the antibody response to COVID-19 vaccines: call for urgent action by the scientific community Open
View article: Species differences in the cerebellar distribution of six members of the Kv1 channel subfamily
Species differences in the cerebellar distribution of six members of the Kv1 channel subfamily Open
Comprehensive studies on the distribution of the Kv1 subfamily have been performed in rat (Chung et al., 2001) and gerbil (Chung et al., 2005), but not in mouse or human. We hypothesized that species differences may exist in the localizati…
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View article: Use of hyperattenuated poliovirus as a replacement for Sabin or wild-type strains for laboratory assays in a post eradication world
Use of hyperattenuated poliovirus as a replacement for Sabin or wild-type strains for laboratory assays in a post eradication world Open
Poliovirus serotype 2 (PV2) has been declared eradicated and was removed from the live vaccine programme in 2016. WHO have developed the Global Action Plan (GAPIII) to describe containment conditions for laboratory work with poliovirus aft…
View article: Differences in Antigenic Structure of Inactivated Polio Vaccines Made From Sabin Live-Attenuated and Wild-Type Poliovirus Strains: Impact on Vaccine Potency Assays
Differences in Antigenic Structure of Inactivated Polio Vaccines Made From Sabin Live-Attenuated and Wild-Type Poliovirus Strains: Impact on Vaccine Potency Assays Open
Homologous references are required to measure the antigen content of IPV products consistently. The first World Health Organization international standard for sIPV was established, with new, specific Sabin D-antigen units assigned.
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View article: Continued use of poliovirus after eradication: hyper‐attenuated strains as a safe alternative for release testing of human immunoglobulins
Continued use of poliovirus after eradication: hyper‐attenuated strains as a safe alternative for release testing of human immunoglobulins Open
BACKGROUND Wild‐type poliovirus may be eradicated soon and under WHO GAPIII guidance, laboratory use will be discontinued or subject to strict containment. Per US Code of Federal Regulations, however, immunoglobulin lot release testing wil…
View article: Environmental Surveillance Reveals Complex Enterovirus Circulation Patterns in Human Populations
Environmental Surveillance Reveals Complex Enterovirus Circulation Patterns in Human Populations Open
Background Enteroviruses are common human pathogens occasionally associated with severe disease, notoriously paralytic poliomyelitis caused by poliovirus. Other enterovirus serotypes such as enterovirus A71 and D68 have been linked to seve…
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View article: Obituary: Geoffrey Schild (1935–2017)
Obituary: Geoffrey Schild (1935–2017) Open
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View article: Isolation of Vaccine-Like Poliovirus Strains in Sewage Samples From the United Kingdom
Isolation of Vaccine-Like Poliovirus Strains in Sewage Samples From the United Kingdom Open
Our ES setup has high sensitivity for polio and non-PV HEV detection, generating nearly whole-genome sequence information. Such ES systems provide critical information to assist the polio eradication endgame and contribute to the improveme…
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View article: Developing Biological Standards for Vaccine Evaluation
Developing Biological Standards for Vaccine Evaluation Open
This perspective describes the process of producing biological reference standards, explains why they are needed, who should use them and in what situations. The aim of this perpective is to promote their use at an early stage of vaccine d…
View article: The effect of new schedules of immunisation on humoral and intestinal immunity to poliovirus and implications for the polio end game
The effect of new schedules of immunisation on humoral and intestinal immunity to poliovirus and implications for the polio end game Open
Poliomyelitis became a serious public health issue for higher income countries in the twentieth century. This led to the development of vaccines in the mid-1950s and the eventual control and elimination of the disease by the 1970s. It rema…
View article: Comparison of platform technologies for assaying antibody to Ebola virus
Comparison of platform technologies for assaying antibody to Ebola virus Open
Funding was from the UK DoH and the Wellcome Tust.
View article: Genetically Thermo-Stabilised, Immunogenic Poliovirus Empty Capsids; a Strategy for Non-replicating Vaccines
Genetically Thermo-Stabilised, Immunogenic Poliovirus Empty Capsids; a Strategy for Non-replicating Vaccines Open
While wild type polio has been nearly eradicated there will be a need to continue immunisation programmes for some time because of the possibility of re-emergence and the existence of long term excreters of poliovirus. All vaccines in curr…
View article: A collaborative study to establish the 3rd WHO International Standard for hepatitis B virus for nucleic acid amplification techniques
A collaborative study to establish the 3rd WHO International Standard for hepatitis B virus for nucleic acid amplification techniques Open
Nucleic acid amplification techniques (NAT) are routinely used for clinical diagnostics and monitoring hepatitis B virus (HBV) infections, and are implemented on a voluntary basis for blood screening. A collaborative study was performed to…