Minori Tamai
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View article: Metastatic subcutaneous Ewing sarcoma mimicking a synchronous second primary neoplasm: a case description
Metastatic subcutaneous Ewing sarcoma mimicking a synchronous second primary neoplasm: a case description Open
View article: A characteristic gene expression profile regulated by <i>ACIN1::NUTM1</i> fusion in a newly identified infant leukaemic cell line and an <scp>ACIN1</scp> :: <scp>NUTM1</scp> ‐inducible model
A characteristic gene expression profile regulated by <i>ACIN1::NUTM1</i> fusion in a newly identified infant leukaemic cell line and an <span>ACIN1</span> :: <span>NUTM1</span> ‐inducible model Open
Summary NUTM1 ‐rearranged ( NUTM1 ‐R) infant acute lymphoblastic leukaemia (ALL) is a newly identified subgroup of non‐ KMT2A ‐R infant ALL, with ACIN1::NUTM1 the most frequent fusion. KMT2A ‐R and NUTM1 ‐R infant ALL are characterized by …
View article: Utility of tolvaptan sodium phosphate for refractory fluid retention in post-transplant sinusoidal obstruction syndrome
Utility of tolvaptan sodium phosphate for refractory fluid retention in post-transplant sinusoidal obstruction syndrome Open
View article: Establishment and chacterization of a novel cell line ICH-BCPALL-3 from B-cell precursor acute lymphoblastic leukemia with TCF3::HLF.
Establishment and chacterization of a novel cell line ICH-BCPALL-3 from B-cell precursor acute lymphoblastic leukemia with TCF3::HLF. Open
In vitro models of acute leukemia are crucial for understandingits biology and developing effective treatments. The authors have established and characterized a novel cell line, ICH-BCPALL-3, which expresses the TCF3::HLF fusion from B-cel…
View article: KF1601, a dual inhibitor of BCR::ABL1 and FLT3, overcomes drug resistance in FLT3+ blast phase chronic myeloid leukemia
KF1601, a dual inhibitor of BCR::ABL1 and FLT3, overcomes drug resistance in FLT3+ blast phase chronic myeloid leukemia Open
View article: Synergistic effect of asciminib with reduced doses of ponatinib in human Ph + myeloid leukemia with the T315M mutation
Synergistic effect of asciminib with reduced doses of ponatinib in human Ph + myeloid leukemia with the T315M mutation Open
In Philadelphia chromosome-positive (Ph +) leukemia, substitution of threonine at the 315 position of BCR::ABL1 with isoleucine (T315I) induces severe resistance to tyrosine kinase inhibitors (TKIs). Of clinical importance, the substitutio…
View article: Utility of the Base Editing System for Introducing Drug-Resistant Gene Mutations Into Human Leukemia Cellular Models
Utility of the Base Editing System for Introducing Drug-Resistant Gene Mutations Into Human Leukemia Cellular Models Open
Background Recent genomic analyses of poor prognostic and relapsed leukemia have revealed the involvement of diverse gene mutations in treatment resistance. These gene mutations are classified into two groups: mutations involving resistanc…
View article: Utility of a Large Series of B‐Cell Precursor Acute Lymphoblastic Leukemia Cell Lines as a Model System
Utility of a Large Series of B‐Cell Precursor Acute Lymphoblastic Leukemia Cell Lines as a Model System Open
Background In B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), chromosomal translocations are strongly associated with prognoses. RNA sequencing (RNA‐seq) is a powerful technology that reveals a close correlation between types of t…
View article: Sensitivity to Tyrosine Kinase Inhibitors in a Human Philadelphia Chromosome-Positive (Ph+) Leukemia Model With the T315I-Inclusive Compound Mutation
Sensitivity to Tyrosine Kinase Inhibitors in a Human Philadelphia Chromosome-Positive (Ph+) Leukemia Model With the T315I-Inclusive Compound Mutation Open
View article: Acquired copy number amplification at the <i>MYC</i> enhancer in human B‐precursor acute lymphoblastic leukemia cell lines
Acquired copy number amplification at the <i>MYC</i> enhancer in human B‐precursor acute lymphoblastic leukemia cell lines Open
Our study highlights the discovery of recurrent copy number alterations in noncoding regions, specifically blood enhancer cluster (BENC-CNA), in B-precursor acute lymphoblastic leukemia (BCP-ALL) cell lines. We demonstrate that BENC-CNA ac…
View article: Involvement of <scp>BCR</scp>::<scp>ABL1</scp> in laminin adhesion of Philadelphia chromosome‐positive acute lymphoblastic leukemia through upregulation of integrin α6
Involvement of <span>BCR</span>::<span>ABL1</span> in laminin adhesion of Philadelphia chromosome‐positive acute lymphoblastic leukemia through upregulation of integrin α6 Open
Background Adhesion of cancer cells to extracellular matrix laminin through the integrin superfamily reportedly induces drug resistance. Heterodimers of integrin α6 (CD49f) with integrin β1 (CD29) or β4 (CD104) are major functional recepto…
View article: Application of prime editing system to introduce <scp><i>TP53</i> R248Q</scp> hotspot mutation in acute lymphoblastic leukemia cell line
Application of prime editing system to introduce <span><i>TP53</i> R248Q</span> hotspot mutation in acute lymphoblastic leukemia cell line Open
In childhood acute lymphoblastic leukemia (ALL), TP53 gene mutation is associated with chemoresistance in a certain population of relapsed cases. To directly verify the association of TP53 gene mutation with chemoresistance of relapsed chi…
View article: In utero tumor development and identification of <i>CTNNB1</i> mutation in a newborn case of ossifying renal tumor of infancy
In utero tumor development and identification of <i>CTNNB1</i> mutation in a newborn case of ossifying renal tumor of infancy Open
To the Editor: Ossifying renal tumor of infancy (ORTI) is a rare pediatric benign renal neoplasm first described in 1980.1 In the latest review of 28 cases, whose diagnostic age was described,2 the median age of diagnosis was 4.3 months ol…
View article: Dose‐dependent tumor regression during sirolimus therapy in an advanced juvenile nasopharyngeal angiofibroma case
Dose‐dependent tumor regression during sirolimus therapy in an advanced juvenile nasopharyngeal angiofibroma case Open
View article: Utility of <i>ASNS</i> gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL
Utility of <i>ASNS</i> gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL Open
Asparaginase is an important agent for the treatment of acute lymphoblastic leukaemia (ALL), but it is occasionally associated with severe adverse events. Thus, for safer and more efficacious therapy, a clinical biomarker predicting aspara…
View article: CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model
CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model Open
View article: Decreased incidence of acute immune thrombocytopenia in children during the COVID-19 pandemic
Decreased incidence of acute immune thrombocytopenia in children during the COVID-19 pandemic Open
View article: Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis
Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis Open
View article: Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis
Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis Open
The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the BCR gene located on chromosome 9q34 and the ABL1 ge…
View article: Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia Open
Glucocorticoid (GC) is a key drug in the treatment of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and the initial GC response is an important prognostic factor. GC receptors play an essential role in GC sensitivity, and somati…
View article: <i>NUDT15</i> polymorphism and <i>NT5C2</i> and <i>PRPS1</i> mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells
<i>NUDT15</i> polymorphism and <i>NT5C2</i> and <i>PRPS1</i> mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells Open
In chemotherapy for childhood acute lymphoblastic leukaemia (ALL), maintenance therapy consisting of oral daily mercaptopurine and weekly methotrexate is important. NUDT15 variant genotype is reportedly highly associated with severe myelos…
View article: Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells
Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells Open
Tyrosine kinase inhibitor (TKI) treatment has dramatically improved the survival of chronic myeloid leukemia (CML) patients, but measurable residual disease typically persists. To more effectively eradicate leukemia cells, simultaneous tar…
View article: KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia
KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia Open
Tyrosine kinase inhibitor (TKI)–treated chronic myeloid leukemia (CML) patients with increased NK cell number have a better prognosis, and thus, NK cells may suppress CML. However, the efficacy of TKIs varies for reasons yet to be fully el…
View article: Loss of KMT2C reprograms the epigenomic landscape in hPSCs resulting in NODAL overexpression and a failure of hemogenic endothelium specification
Loss of KMT2C reprograms the epigenomic landscape in hPSCs resulting in NODAL overexpression and a failure of hemogenic endothelium specification Open
Germline or somatic variation in the family of KMT2 lysine methyltransferases have been associated with a variety of congenital disorders and cancers. Notably, KMT2A-fusions are prevalent in 70% of infant leukaemias but fail to phen…
View article: IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform
IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform Open
View article: Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines
Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines Open
Background The genetic variants of the ARID5B gene have recently been reported to be associated with disease susceptibility and treatment outcome in childhood acute lymphoblastic leukemia (ALL). However, few studies have explored the assoc…
View article: Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines
Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines Open
Background The genetic variants of the ARID5B gene have recently been reported to be associated with disease susceptibility and treatment outcome in childhood acute lymphoblastic leukemia (ALL). However, few studies have explored the assoc…
View article: Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines
Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines Open
Background The genetic variants of the ARID5B gene have recently been reported to be associated with disease susceptibility and treatment outcome in childhood acute lymphoblastic leukemia (ALL). However, few studies have explored the assoc…
View article: Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia
Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia Open
Therapy resistance in leukemia may be due to cancer cell-intrinsic and/or -extrinsic mechanisms. Mutations within BCR-ABL1 , the oncogene giving rise to chronic myeloid leukemia (CML), lead to resistance to tyrosine kinase inhibitors (TKI)…
View article: Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines
Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines Open
Background The genetic variants of the ARID5B gene have recently been reported to be associated with disease susceptibility and treatment outcome in childhood acute lymphoblastic leukemia (ALL). However, few studies have explored the assoc…