Minoru Takemoto
YOU?
Author Swipe
View article: Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling
Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling Open
Transformation of cardiac fibroblasts into matrix-producing myofibroblasts plays an important role in tissue repair and fibrosis after myocardial injury. Tcf21 is a basic helix-loop-helix transcription factor that is essential for the deve…
View article: Increased autoantibodies against incretin indicate poor prognosis in patients with diabetes
Increased autoantibodies against incretin indicate poor prognosis in patients with diabetes Open
This retrospective cohort study aimed to elucidate the clinical significance of measuring autoantibodies against incretins in diabetes. We enrolled 274 patients with diabetes (mean age ± standard deviation: 63.1 ± 12.1 years) and 109 healt…
View article: Autoantibody against UBE2E3 is a common biomarker for atherosclerotic diseases and digestive tract cancer
Autoantibody against UBE2E3 is a common biomarker for atherosclerotic diseases and digestive tract cancer Open
Aim: Atherosclerosis and diabetes mellitus (DM) often lead to severe conditions, such as acute ischemic stroke (AIS), cardiovascular disease (CVD), and chronic kidney disease (CKD). Some cancers are also associated with atherosclerosis. Th…
View article: Dual inhibition of GTP-bound KRAS and mTOR in lung adenocarcinoma and squamous cell carcinoma harboring KRAS G12C
Dual inhibition of GTP-bound KRAS and mTOR in lung adenocarcinoma and squamous cell carcinoma harboring KRAS G12C Open
KRAS G12C inhibitor plus RAD001 consistently revealed synergism. Targeting KRAS G12C and mTOR abrogates the RAS-MEK-ERK and PI3K-AKT-mTOR pathways. Our data suggests that a combined strategy targeting GTP-bound KRAS G12C and mTOR shows pro…
View article: Recommendations for cancer screening and surveillance in patients with Werner syndrome
Recommendations for cancer screening and surveillance in patients with Werner syndrome Open
Werner syndrome (WS) is an autosomal recessive premature aging disorder caused by mutations in the WRN gene. It is characterized by the development of age-related diseases, such as juvenile bilateral cataracts, gray hair, hair loss, insuli…
View article: Serum anti‑KIAA0513 antibody as a common biomarker for mortal atherosclerotic and cancerous diseases
Serum anti‑KIAA0513 antibody as a common biomarker for mortal atherosclerotic and cancerous diseases Open
Numerous antibody biomarkers have been reported for cancer and atherosclerosis-related diseases. The major complications of atherosclerosis and diabetes mellitus (DM) are acute ischemic stroke (AIS), cardiovascular disease (CVD) and chroni…
View article: JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases
JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases Open
Inflammation is closely associated with cerebrovascular diseases, cardiovascular diseases, diabetes, and cancers, and it is accompanied by the development of autoantibodies in the early stage of inflammation-related diseases. Hence, it is …
View article: JMJD6 Autoantibodies as a Potential Biomarker for Atherosclerosis-Related Diseases
JMJD6 Autoantibodies as a Potential Biomarker for Atherosclerosis-Related Diseases Open
Atherosclerosis is associated with vascular diseases, diabetes, and cancers. The Jumonji C-domain-containing 6 (JMJD6) gene plays an important role in diverse biological processes. In addition, autoantibodies are reportedly useful in the e…
View article: Sex differences in symptom presentation and their impact on diagnostic accuracy in <scp>Werner</scp> syndrome
Sex differences in symptom presentation and their impact on diagnostic accuracy in <span>Werner</span> syndrome Open
Aim Whether sex differences exist in hereditary progeroid syndromes remains unclear. In this study, we investigated sex differences in patients with Werner syndrome (WS), a model of human aging, using patient data at the time of diagnosis.…
View article: Iron overload may be critical for liver dysfunction in anorexia nervosa, and the role of haematocrit-adjusted albumin in assessing nutritional status: a case report
Iron overload may be critical for liver dysfunction in anorexia nervosa, and the role of haematocrit-adjusted albumin in assessing nutritional status: a case report Open
Background Anorexia nervosa (AN) is frequently associated with liver dysfunction, but the precise mechanism remains undefined. Since the nutritional marker albumin has a low correlation with changes in body weight in AN, and patients with …
View article: Serum anti-PCK1 antibody levels are a prognostic factor for patients with diabetes mellitus
Serum anti-PCK1 antibody levels are a prognostic factor for patients with diabetes mellitus Open
Background Autoantibodies develop in autoimmune diseases, cancer, diabetes mellitus (DM), and atherosclerosis-related diseases. However, autoantibody biomarkers have not been successfully examined for diagnosis and therapy. Methods Serolog…
View article: Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events
Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events Open
Psoriasis is a chronic inflammatory skin disease that is associated with obesity and myocardial infarction. Obesity‐induced changes in lipid metabolism promote T helper 17 (Th17) cell differentiation, which in turn promotes chronic inflamm…
View article: Safety and effectiveness of metabolic surgery in older Japanese patients
Safety and effectiveness of metabolic surgery in older Japanese patients Open
Aim According to the current guidelines in Japan, the upper age limit for bariatric and metabolic surgery is 65 y. This study aimed to examine the appropriateness of this upper age limit. Methods Using the database maintained by the Japane…
View article: Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry
Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry Open
Werner syndrome is an adult-onset progeria syndrome that results in various complications. This study aimed to clarify the profile and secular variation of the disease. Fifty-one patients were enrolled and registered in the Werner Syndrome…
View article: Utility of atherosclerosis-associated serum antibodies against colony-stimulating factor 2 in predicting the onset of acute ischemic stroke and prognosis of colorectal cancer
Utility of atherosclerosis-associated serum antibodies against colony-stimulating factor 2 in predicting the onset of acute ischemic stroke and prognosis of colorectal cancer Open
Introduction Autoantibodies against inflammatory cytokines may be used for the prevention of atherosclerosis. Preclinical studies consider colony-stimulating factor 2 (CSF2) as an essential cytokine with a causal relationship to atheroscle…
View article: A case of doxorubicin and cyclophosphamide therapy-induced type 1 diabetes: a case report
A case of doxorubicin and cyclophosphamide therapy-induced type 1 diabetes: a case report Open
Background Patients receiving immune checkpoint inhibitors have been reported to develop autoimmune endocrine diseases, including type 1 diabetes, although few drugs have been shown to induce type 1 diabetes. Additionally, it is important …
View article: Serum anti-PCK1 antibody levels are prognostic factor for the patients with diabetes mellitus
Serum anti-PCK1 antibody levels are prognostic factor for the patients with diabetes mellitus Open
Background: Autoantibodies develop in autoimmune diseases, cancer, diabetes mellitus (DM),and atherosclerosis-related diseases. However, autoantibody biomarkers have not been successfully examined for diagnosis and therapy. Methods: Serolo…
View article: Association of high proprotein convertase subtilisin/kexin type 9 antibody level with poor prognosis in patients with diabetes: A prospective cross-sectional study
Association of high proprotein convertase subtilisin/kexin type 9 antibody level with poor prognosis in patients with diabetes: A prospective cross-sectional study Open
Background In addition to pathogenic autoantibodies, polyclonal autoantibodies with unknown physiological roles and pathogenicity are produced in the body. Moreover, serum antibodies against the proprotein convertase subtilisin/kexin type …
View article: High proprotein convertase subtilisin/kexin type 9 antibody level is associated with poor prognosis in patients with diabetes: A Prospective cross-sectional study
High proprotein convertase subtilisin/kexin type 9 antibody level is associated with poor prognosis in patients with diabetes: A Prospective cross-sectional study Open
Background In addition to pathogenic autoantibodies, polyclonal autoantibodies with unknown physiological roles and pathogenicity are produced in the body. Moreover, serum antibodies against the proprotein convertase subtilisin/kexin type …
View article: The Incidence and Risk Factors of Hyponatremia in Pulmonary Tuberculosis
The Incidence and Risk Factors of Hyponatremia in Pulmonary Tuberculosis Open
Context The syndrome of inappropriate antidiuresis (SIAD) with euvolemic hyponatremia may occur in patients with pulmonary tuberculosis (PTB), but little is known about the clinical characteristics of SIAD-associated hyponatremia in PTB pa…
View article: Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium
Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium Open
Objectives Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA progression and alleviates the ensuing disease effects remain unknown. The aim of the pr…