Minoru Wakamori
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View article: Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin
Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin Open
Epiprofin (Epfn), an Sp/KLF family transcription factor that regulates cell proliferation and determines cell fates, is essential for normal skin, hair follicle, and tooth development. We found that Epfn was expressed in parathyroid glands…
View article: Wnt5a, produced by physiological mechanical stimulation on the periodontal ligament, regulates neuronal differentiation in the trigeminal mesencephalic nucleus
Wnt5a, produced by physiological mechanical stimulation on the periodontal ligament, regulates neuronal differentiation in the trigeminal mesencephalic nucleus Open
Although many cohort studies have reported an association between poor oral function and the development of dementia, the detailed molecular physiological mechanisms linking them are still unclear. When occlusal pressure is applied to the …
View article: A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development
A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development Open
Myoepithelial cells (MECs) are responsible for receiving stimuli from the central nervous system and translating their responses into the form of secretion into glandular tissue, including salivary glands (SG), sweet glands, and mammary gl…
View article: Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder
Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder Open
Several large-scale whole-exome sequencing studies in patients with schizophrenia (SCZ) and autism spectrum disorder (ASD) have identified rare variants with modest or strong effect size as genetic risk factors. Dysregulation of cellular c…
View article: Wnt5a, produced by mechanically stimulated periodontal ligament cells, modulates differentiation of trigeminal ganglion cells
Wnt5a, produced by mechanically stimulated periodontal ligament cells, modulates differentiation of trigeminal ganglion cells Open
The periodontal ligaments (PDLs), located between the tooth and alveolar bones, anchor the tooth and absorb the daily chewing force by mastication. In addition, the Ruffini's corpuscles in the PDLs play a pivotal role in pressure sensing t…
View article: Inhibitory effects of CRAC channel current by anti-depressant
Inhibitory effects of CRAC channel current by anti-depressant Open
Activation of glial cells contributes neural disorders like depression and neuropathic pain through the release of nitric oxide and cytokines. The release depends on intracellular Ca2+ levels. One of the Ca2+ entry pathways is Ca2+ release…
View article: Challenge for Functional Salivary Gland Regeneration
Challenge for Functional Salivary Gland Regeneration Open
Saliva plays an important role in maintaining oral hygiene, buffering, digestive, antibacterial, immunological functions in addition to keeping the oral cavity moist, and thereby it contributes disease prevention and health maintenance. Xe…
View article: Capsaicin and Proton Differently Modulate Activation Kinetics of Mouse Transient Receptor Potential Vanilloid-1 Channel Induced by Depolarization
Capsaicin and Proton Differently Modulate Activation Kinetics of Mouse Transient Receptor Potential Vanilloid-1 Channel Induced by Depolarization Open
The transient receptor potential vanilloid type 1 (TRPV1) channel is a non-selective cation channel expressed with transient receptor potential ankyrin type 1 (TRPA1) in small and medial size neurons of the dorsal root ganglions and trigem…
View article: Inhibition of CRAC channel current by TRPV1 channel agonist and antagonist in RBL cells
Inhibition of CRAC channel current by TRPV1 channel agonist and antagonist in RBL cells Open
Calcium ions (Ca2+) play extremely important roles, especially, as a second messenger in the cells. In excitable cells, Ca2+ permeable ligand-gated channels and voltage-gated Ca2+ channels pass Ca2+ into the cell. In non-excitable cells, C…
View article: Paeonol, an Ingredient of Kamishoyosan, Reduces Intracellular Lipid Accumulation by Inhibiting Glucocorticoid Receptor Activity in 3T3-L1 Cells
Paeonol, an Ingredient of Kamishoyosan, Reduces Intracellular Lipid Accumulation by Inhibiting Glucocorticoid Receptor Activity in 3T3-L1 Cells Open
Excessive triglyceride accumulation in lipid-metabolizing tissues is associated with an increased risk of a variety of metabolic diseases. Kamishoyosan (KSS) is a Kampo composed of 10 constituent herbs, and contains moutan cortex (MC) and …
View article: Development of photoswitchable protein that inhibits actin filament polymerization by near-infrared light irradiation
Development of photoswitchable protein that inhibits actin filament polymerization by near-infrared light irradiation Open
Actin filaments in cells are essential for many cell functions such as cell migration, proliferation, and contraction. We wondered if we could regulate actin polymerization non-invasively, we could manipulate the mechanical force required …
View article: Elucidation of neurite outgrowth by Wnt5a Ca<sup>2 +</sup>-dependently produced in periodontal ligament cells
Elucidation of neurite outgrowth by Wnt5a Ca<sup>2 +</sup>-dependently produced in periodontal ligament cells Open
Sensory nerves in the periodontal ligament (PDL) sense the occlusal pressure, and contribute to adjust the occlusal force. The occlusal mechanical stimulation is necessary for nerve maturation in the PDL (Miki et al., 2015). Since there is…
View article: Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition
Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition Open
View article: Zinc promotes differentiation and proliferation of MC3T3-E1 cells through activation of Ca<sup>2+</sup>-activatide K<sup>+</sup> channels
Zinc promotes differentiation and proliferation of MC3T3-E1 cells through activation of Ca<sup>2+</sup>-activatide K<sup>+</sup> channels Open
Zinc, as the divalent cation (Zn2+) and the second most abundant trace metal in the human body, plays pivotal roles in the proliferation and differentiation of osteoblasts. It is well known that the Ca2+-activated K+ (KCa) channels regulat…
View article: Wnt5a, produced in mechanically stimulated PDL cells <i>via</i> MEK (1/2) and/or PI3K pathways, promotes neurite elongation
Wnt5a, produced in mechanically stimulated PDL cells <i>via</i> MEK (1/2) and/or PI3K pathways, promotes neurite elongation Open
The periodontal ligaments (PDLs), located at the interface between tooth and alveolar bones, are responsible for tooth planting and pressure absorbing actions. The Ruffini's corpuscles, one of the mechanoreceptors, located in the PDLs play…
View article: Differential binding of tetrodotoxin and its derivatives to voltage‐sensitive sodium channel subtypes (Na<sub>v</sub>1.1 to Na<sub>v</sub>1.7)
Differential binding of tetrodotoxin and its derivatives to voltage‐sensitive sodium channel subtypes (Na<sub>v</sub>1.1 to Na<sub>v</sub>1.7) Open
Background and Purpose The development of subtype‐selective ligands to inhibit voltage‐sensitive sodium channels (VSSCs) has been attempted with the aim of developing therapeutic compounds. Tetrodotoxin (TTX) is a toxin from pufferfish tha…
View article: Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice
Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice Open
Alternative splicing (AS) that occurs at the final coding exon (exon 47) of the Cav2.1 voltage-gated calcium channel (VGCC) gene produces two major isoforms in the brain, MPI and MPc. These isoforms differ in their splice acceptor sites; h…
View article: Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B
Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B Open
View article: Unraveling the rat blood genome-wide transcriptome after oral administration of lavender oil by a two-color dye-swap DNA microarray approach
Unraveling the rat blood genome-wide transcriptome after oral administration of lavender oil by a two-color dye-swap DNA microarray approach Open
Lavender oil (LO) is a commonly used essential oil in aromatherapy as non-traditional medicine. With an aim to demonstrate LO effects on the body, we have recently established an animal model investigating the influence of orally administe…