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View article: Drug repositioning of regorafenib for renal cell carcinoma identifies <i>DDR2</i> ‑associated sensitivity in ACHN models
Drug repositioning of regorafenib for renal cell carcinoma identifies <i>DDR2</i> ‑associated sensitivity in ACHN models Open
Renal cell carcinoma (RCC) is heterogeneous and frequently refractory to cytotoxic therapy. We investigated whether contexts with elevated DDR2-a collagenactivated receptor tyrosine kinase-are preferentially sensitive to regorafenib, a mul…
View article: Impact of Biologics on Comorbidities in Patients with Psoriasis or Psoriatic Arthritis
Impact of Biologics on Comorbidities in Patients with Psoriasis or Psoriatic Arthritis Open
Background/Objectives: Psoriasis and psoriatic arthritis are associated with various comorbidities, particularly cardiovascular conditions. Although biologics are increasingly used to manage moderate-to-severe disease, their effect on como…
View article: Effect of Pulsed Electromagnetic Field (PEMF) on Pressure Ulcer in BALB/c and C57BL/6 Mice
Effect of Pulsed Electromagnetic Field (PEMF) on Pressure Ulcer in BALB/c and C57BL/6 Mice Open
Pressure ulcers (PUs) are localized injuries caused by prolonged mechanical loading and ischemia, often leading to delayed healing and high recurrence rates. Although conventional treatments aim to support tissue repair, their efficacy rem…
View article: AI-augmented differential diagnosis of granulomatous rosacea and lupus miliaris disseminatus faciei: A 23–year retrospective pilot study
AI-augmented differential diagnosis of granulomatous rosacea and lupus miliaris disseminatus faciei: A 23–year retrospective pilot study Open
Granulomatous rosacea (GR) and lupus miliaris disseminatus faciei (LMDF) exhibit overlapping clinical features, making their differentiation challenging. While histopathological examination remains the gold standard, it is invasive and tim…
View article: Interobserver agreement analysis among renal pathologists in classification of lupus nephritis using a digital pathology image dataset: after a third evaluation
Interobserver agreement analysis among renal pathologists in classification of lupus nephritis using a digital pathology image dataset: after a third evaluation Open
This study conducted an interobserver agreement analysis of Korean pathologists for lupus nephritis, with the goal of increasing agreement through education. Although the education increased overall agreement, items like "mesangial hyperce…
View article: Tuberculous Meningoencephalitis with Skull Perforation Possibly Mistaken for Trauma: An Autopsy Case Report
Tuberculous Meningoencephalitis with Skull Perforation Possibly Mistaken for Trauma: An Autopsy Case Report Open
Although tuberculosis can affect various parts of the central nervous system, tuberculous meningitis is the most lethal form. Tuberculous meningoencephalitis and cranial tuberculosis are extremely rare. Therefore, the authors present an au…
View article: Clinical and pathological significance of Orai1 channel expression in human diabetic nephropathy
Clinical and pathological significance of Orai1 channel expression in human diabetic nephropathy Open
Background: Targeted therapies for diabetic nephropathy (DN) are lacking, partly due to their irreversible nature. The role of Orai1, a store-operated Ca2+ channel, in DN remains debated, with conflicting evidence on its effect on proteinu…
View article: Glomerulonephritis following COVID-19 infection or vaccination: a multicenter study in South Korea
Glomerulonephritis following COVID-19 infection or vaccination: a multicenter study in South Korea Open
Background: Despite the widespread impact of the severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) and vaccination in South Korea, our understanding of kidney diseases following these events remains limit…
View article: Orbital floor defect caused by invasive aspergillosis: a case report and literature review
Orbital floor defect caused by invasive aspergillosis: a case report and literature review Open
Fungal sinusitis is relatively rare, but it has become more common in recent years. When fungal sinusitis invades the orbit, it can cause proptosis, chemosis, ophthalmoplegia, retroorbital pain, and vision impairment. We present a case of …
View article: Intramuscular epidermal cyst in the masticator space: a case report
Intramuscular epidermal cyst in the masticator space: a case report Open
An epidermal cyst, also known as an epidermoid cyst or epidermal inclusion cyst, is the most prevalent type of cutaneous cyst. This noncancerous lesion can appear anywhere on the body, typically presenting as an asymptomatic dermal nodule …
View article: #3474 ROLE OF INTEGRIN, FIBRONECTIN, AND UPAR IN PODOCYTE-GLOMERULAR BASEMENT MEMBRANE INTERACTION UNDER FLUID SHEAR STRESS
#3474 ROLE OF INTEGRIN, FIBRONECTIN, AND UPAR IN PODOCYTE-GLOMERULAR BASEMENT MEMBRANE INTERACTION UNDER FLUID SHEAR STRESS Open
Background and Aims Podocyte-glomerular basement membrane (GBM) interaction is the main component to maintain glomerular filtration barrier. Interestingly, the podocyte-GBM interaction is not static, but dynamic according to various podocy…
View article: Pathological validation of the Japanese Renal Pathology Society classification and challenges in predicting renalprognosis in patients with diabetic nephropathy
Pathological validation of the Japanese Renal Pathology Society classification and challenges in predicting renalprognosis in patients with diabetic nephropathy Open
Background: Diabetic nephropathy (DN) accounts for approximately half of all cases of chronic kidney disease (CKD) and end-stage kidney disease worldwide. The Renal Pathology Society (RPS) classification has been used to predict the renal …
View article: Pulsed Electromagnetic Field (PEMF) Treatment Reduces Lipopolysaccharide-Induced Septic Shock in Mice
Pulsed Electromagnetic Field (PEMF) Treatment Reduces Lipopolysaccharide-Induced Septic Shock in Mice Open
Despite advances in medicine, mortality due to sepsis has not decreased. Pulsed electromagnetic field (PEMF) therapy is emerging as an alternative treatment in many inflammation-related diseases. However, there are few studies on the appli…
View article: Intensely Pruritic Papules and Plaques in Waldenstrom's Macroglobulinemia
Intensely Pruritic Papules and Plaques in Waldenstrom's Macroglobulinemia Open
Waldenstrom's macroglobulinemia (WM) is lymphoplasmacytoid malignancy that affects B lymphocytes. Cutaneous involvement of WM is rare, but various cutaneous manifestations have been reported. These findings are due to various pathological …
View article: Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes
Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes Open
Klotho is a type-1 membrane protein predominantly produced in the kidney, the extracellular domain of which is secreted into the systemic circulation. Membranous and secreted Klotho protect organs, including the kidney, but whether and how…
View article: Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome
Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome Open
Klotho functions as a tumor suppressor predominantly expressed in renal tubular cells, the origin of clear cell renal cell carcinoma (ccRCC). Altered expression and/or activity of growth factor receptor have been implicated in ccRCC develo…
View article: Orai1 Expression Is Closely Related with Favorable Prognostic Factors in Clear Cell Renal Cell Carcinoma
Orai1 Expression Is Closely Related with Favorable Prognostic Factors in Clear Cell Renal Cell Carcinoma Open
Store-operated calcium (Ca(2+)) entry (SOCE) is the principal Ca(2+) entry route in non-excitable cells, including cancer cells. We previously demonstrated that Orai1 and STIM1, the molecular components of SOCE, are involved in tumorigenes…
View article: Foam cells and the pathogenesis of kidney disease
Foam cells and the pathogenesis of kidney disease Open
Renal foam cells remain an enigma. Extrapolating from studies of atherosclerosis suggests that therapeutics targeting mitochondrial reactive oxygen species production, or modulating cholesterol and lipoprotein uptake or egress from these c…
View article: Penile Mass Caused by<i>Mycobacterium tuberculosis</i>
Penile Mass Caused by<i>Mycobacterium tuberculosis</i> Open
Tuberculosis of the penis is rare. The clinical features of penile tuberculosis are usually manifested as ulceration or scars. However, the authors encountered a case of penile tuberculosis that presented as a mass. A painless nodule at th…
View article: Pathology and Renal Outcome of IgA Nephropathy
Pathology and Renal Outcome of IgA Nephropathy Open
Background/Aims: The Oxford classification of immunoglobulin A nephropathy (IgAN) is a pathology-based prognostic classification system. However, further study is needed to determine its validity. We studied the relationships between the O…