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View article: UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation
UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation Open
NLRP3 (NOD, LRR and pyrin domain‐containing protein 3) inflammasome is important for host defense against infections and maintaining homeostasis. Aberrant activation of NLRP3 inflammasome is closely related to various inflammatory diseases…
View article: Deciphering the molecular and cellular atlas of immune cells in septic patients with different bacterial infections
Deciphering the molecular and cellular atlas of immune cells in septic patients with different bacterial infections Open
Background Sepsis is a life-threatening organ dysfunction caused by abnormal immune responses to various, predominantly bacterial, infections. Different bacterial infections lead to substantial variation in disease manifestation and therap…
View article: Identification and validation of key biomarkers based on RNA methylation genes in sepsis
Identification and validation of key biomarkers based on RNA methylation genes in sepsis Open
Background RNA methylation is closely involved in immune regulation, but its role in sepsis remains unknown. Here, we aim to investigate the role of RNA methylation-associated genes (RMGs) in classifying and diagnosing of sepsis. Methods F…
View article: Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus
Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus Open
Stated in the Acknowledgements section of the manuscript.
View article: Integrative analysis of omics summary data reveals putative mechanisms linked to different cell populations in systemic lupus erythematosus
Integrative analysis of omics summary data reveals putative mechanisms linked to different cell populations in systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is a complex disease involving many interactions at the molecular level, the details of which remain unclear. Here, we demonstrated an analytical paradigm of prioritizing genes and regulatory elements bas…
View article: Calculation of Similarity Between 26 Autoimmune Diseases Based on Three Measurements Including Network, Function, and Semantics
Calculation of Similarity Between 26 Autoimmune Diseases Based on Three Measurements Including Network, Function, and Semantics Open
Autoimmune diseases (ADs) are a broad range of diseases in which the immune response to self-antigens causes damage or disorder of tissues, and the genetic susceptibility is regarded as the key etiology of ADs. Accumulating evidence has su…
View article: Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN‐High,” “NE‐High,” and “Mixed”
Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN‐High,” “NE‐High,” and “Mixed” Open
Purpose . Systemic lupus erythematosus (SLE) is a systemic and multifactorial autoimmune disease, and its diverse clinical manifestations affect molecular diagnosis and drug benefits. Our study was aimed at defining the SLE subtypes based …