Minting Chen
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View article: Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer
Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer Open
Excess cholesterol is positively correlated with colorectal cancer (CRC). Current therapeutic strategies for modulating cholesterol levels in CRC are limited and often come with complications. Here, we demonstrated that microbiome shunting…
View article: Synergisitic anti-colorectal cancer effects of WNT974 combined with artesunate via cooperative regulation of p21, p27, and AKT
Synergisitic anti-colorectal cancer effects of WNT974 combined with artesunate via cooperative regulation of p21, p27, and AKT Open
Objective: To evaluate the synergistic effects and underlying mechanisms of WNT974 and artesunate (ART) combination therapy in the treatment of colorectal cancer (CRC). Methods: We conducted an initial assessment of the synergistic impact …
View article: Omics approach to reveal the effects of obesity on the protein profiles of the exosomes derived from different adipose depots
Omics approach to reveal the effects of obesity on the protein profiles of the exosomes derived from different adipose depots Open
Background: Obesity affects the cargo packaging of the adipocyte-derived exosomes. Furthermore, adipocytes in different adipose tissues have different genetic makeup, the cargo contents of the exosomes derived from different adipose tissue…
View article: Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level
Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level Open
Currently, no frontline treatment is effective for the late-stage colorectal cancer (CRC). Understanding the molecular differences in different stages of CRC can help us to identify the critical therapeutic targets for designing therapeuti…
View article: Baicalein is a novel TLR4‐targeting therapeutics agent that inhibits TLR4/HIF‐1α/VEGF signaling pathway in colorectal cancer
Baicalein is a novel TLR4‐targeting therapeutics agent that inhibits TLR4/HIF‐1α/VEGF signaling pathway in colorectal cancer Open
Toll-like receptor 4(TLR4) is a rational therapeutic target. We have discovered that baicalein directly binds to TLR4, which is a strategy to inhibit TLR4 activity. In our study, molecular docking showed that baicalein directly bound to TL…
View article: Combination of Artesunate and WNT974 Induces KRAS Protein Degradation by Upregulating E3 Ligase ANACP2 and β-TrCP in the Ubiquitin–Proteasome Pathway
Combination of Artesunate and WNT974 Induces KRAS Protein Degradation by Upregulating E3 Ligase ANACP2 and β-TrCP in the Ubiquitin–Proteasome Pathway Open
BackgroundKRAS mutation is one of the dominant gene mutations in colorectal cancer (CRC). Up to present, targeting KRAS for CRC treatment remains a clinical challenge. WNT974 (LGK974) is a porcupine inhibitor that interferes Wnt signaling …
View article: Combination of Artesunate and WNT974 Induces KRAS Protein Degradation by Upregulating E3 Ligase ANACP2 and β-TrCP in the Ubiquitin–proteasome Pathway
Combination of Artesunate and WNT974 Induces KRAS Protein Degradation by Upregulating E3 Ligase ANACP2 and β-TrCP in the Ubiquitin–proteasome Pathway Open
Background KRAS mutation is one of the dominant gene mutations in colorectal cancer (CRC). Up to present, targeting KRAS for CRC treatment remains a clinical challenge. WNT974 (LGK974) is a porcupine inhibitor that interferes Wnt signaling…
View article: Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor α and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis
Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor α and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis Open
Hepatocellular carcinoma (HCC) is difficult to treat, and is the second leading cause of cancer-related death worldwide. This study aimed to examine whether combination of wogonin and artesunate exhibits synergistic anti-HCC effect. Our da…
View article: The advantages of using Scutellaria baicalensis and its flavonoids for the management of non-viral hepatocellular carcinoma
The advantages of using Scutellaria baicalensis and its flavonoids for the management of non-viral hepatocellular carcinoma Open
Scutellaria baicalensis Georgi is functional food and potential therapeutics for liver cancer. Among all the primary liver cancer, hepatocellular carcinoma (HCC) is the most common sub-type. The non-viral causes of HCC include diabetes mel…
View article: The therapeutic potential of Scutellaria baicalensis for the treatment of obesity-driven hepatocellular carcinoma
The therapeutic potential of Scutellaria baicalensis for the treatment of obesity-driven hepatocellular carcinoma Open
Obesity is closely associated with non-alcoholic fatty liver disease which will develop into hepatocellular carcinoma (HCC). Obesity per se is also an independent risk factor for HCC. Lipotoxicity, adipose tissue remodeling, modulation of …
View article: Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity
Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity Open
Visceral obesity is the excess deposition of visceral fat within the abdominal cavity that surrounds vital organs. Visceral obesity is directly associated with metabolic syndrome, breast cancer and endometrial cancer. In visceral obese sub…
View article: High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner
High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner Open
Epidemiology studies indicate that consumption of high-fat diet (HFD) is directly associated with the development of colorectal cancer (CRC). However, the exact component in HFD and the mechanism underlying its effect on CRC growth remaine…