Explanipedia

Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform Open

Yu‐Qing Zhang, Zehua Li, Jessica Ritter, Elliott J. Brea, Navin R. Mahadevan , et al. · 2025

MARAGE: Transferable Multi-Model Adversarial Attack for Retrieval-Augmented Generation Data Extraction Open

Xiaoling Hu, Eric Minwei Liu, Weizhou Wang, Xiangyu Guo, David Lie · 2025

Retrieval-Augmented Generation (RAG) offers a solution to mitigate hallucinations in Large Language Models (LLMs) by grounding their outputs to knowledge retrieved from external sources. The use of private resources and data in constructin…

Advancing Equality: Harnessing Generative AI to Combat Systemic Racism Open

Saadia Gabriel, Jessy Xinyi Han, Eric Minwei Liu, Isha Puri, Wonyoung So , et al. · 2024

Systemic racism, an issue deeply entrenched in various sectors of American society, continues to cast a shadow over the nation's progress towards equality and justice. This paper showcases some of generative artificial intelligence (AI) po…

Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma Open

Mahnoor Mahmood, Eric Minwei Liu, Amy L. Shergold, Elisabetta Tolla, Jacqueline Tait-Mulder , et al. · 2024

Functional and translational consequences of immunometabolic coevolution in ccRCC Open

Ed Reznik, Cerise Tang, Amy Xie, Eric Minwei Liu, Fengshen Kuo , et al. · 2023

Background Tumor cell phenotypes and anti-tumor immune responses are shaped by local metabolite availability, but intratumoral metabolite heterogeneity (IMH) and its phenotypic consequences remain poorly understood. In vitro mechanistic st…

2023 Kidney Cancer Research Summit Abstracts Open

Georges Gebrael, Ged Mbbs, Irina Rifkind, Lori Tony, Keegan Daugherty , et al. · 2023

The 5th Kidney Cancer Research Summit (KCRS) took place on July 13th & 14th, 2023 as a hybrid event both in Boston, Massachusetts at the InterContinental Boston, and virtually via Zoom webinar. The conference format consisted of oral prese…

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC Open

Cerise Tang, Amy Xie, Eric Minwei Liu, Fengshen Kuo, Min‐Soo Kim , et al. · 2023

Tumor cell phenotypes and anti-tumor immune responses are shaped by local metabolite availability, but intratumoral metabolite heterogeneity (IMH) and its phenotypic consequences remain poorly understood. To study IMH, we profiled tumor/no…

A multimodal atlas of tumour metabolism reveals the architecture of gene–metabolite covariation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2023

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade Open

Mahnoor Mahmood, Eric Minwei Liu, Amy L. Shergold, Elisabetta Tolla, Jacqueline Tait-Mulder , et al. · 2023

Summary The mitochondrial genome encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutation in the cancer genome, with truncating mutations in respiratory co…

Author Correction: Integrative pathway enrichment analysis of multivariate omics data Open

Marta Paczkowska, Jonathan Barenboim, Nardnisa Sintupisut, Natalie S. Fox, Helen Zhu , et al. · 2022

Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower Open

Shimin Shuai, Federico Abascal, Samirkumar B. Amin, Gary D. Bader, Pratiti Bandopadhayay , et al. · 2022

Author Correction: Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis Open

Joana Carlevaro-Fita, Andrés Lanzós, Lars Feuerbach, Chen Hong, David Mas-Ponte , et al. · 2022

Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes Open

Matthew A. Reyna, David Haan, Marta Paczkowska, Lieven P. C. Verbeke, Miguél Vázquez , et al. · 2022

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2022

Tumor metabolism is controlled by coordinated changes in metabolite abundance and gene expression, but simultaneous quantification of metabolites and transcripts in primary tissue is rare. To overcome this limitation and study gene-metabol…

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2022

pancancer metabolomics study

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2022

pancancer metabolomics study

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2022

pancancer metabolomics study

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Covariation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2022

pancancer metabolomics study

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2022

pancancer metabolomics study

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2022

pancancer metabolomics study

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2022

pancancer metabolomics study

Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma Open

Ian Ganly, Eric Minwei Liu, Fengshen Kuo, Vladimir Makarov, Yiyu Dong , et al. · 2022

Hürthle cell carcinomas (HCCs) display two exceptional genotypes: near-homoplasmic mutation of mitochondrial DNA (mtDNA) and genome-wide loss of heterozygosity (gLOH). To understand the phenotypic consequences of these genetic alterations,…

Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets Open

Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martínez-Fundichely , et al. · 2022

In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence leads to clinically aggressive tumors with few therapeutic options. We used ATAC-seq (assay for transposase-accessible chromatin sequencing), RNA…

Mitonuclear Genotype Remodels the Metabolic and Microenvironmental Landscape of Hurthle Cell Carcinoma Open

Eric Minwei Liu, Ed Reznik · 2022

Processed metabolomics, RNA-seq data, and R scripts with instructions to generate relevant analysis and figures

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2022

pancancer metabolomics study

Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway Open

Jian Carrot‐Zhang, Xiaotong Yao, Siddhartha Devarakonda, Aditya Deshpande, Jeffrey S. Damrauer , et al. · 2021

Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway Open

Jian Carrot‐Zhang, Xiaotong Yao, Siddhartha Devarakonda, Aditya Deshpande, Jeffrey S. Damrauer , et al. · 2021

RTK/RAS/RAF pathway alterations (RPAs) are a hallmark of lung adenocarcinoma (LUAD). In this study, we use whole-genome sequencing (WGS) of 85 cases found to be RPA(-) by previous studies from The Cancer Genome Atlas (TCGA) to characterize…

netboxr: Automated discovery of biological process modules by network analysis in R Open

Eric Minwei Liu, Augustin Luna, Guanlan Dong, Chris Sander · 2020

The netboxr package is free and open-sourced under the GNU GPL-3 license R package available at https://www.bioconductor.org/packages/release/bioc/html/netboxr.html.

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities Open

Fanying Tang, Shangqian Wang, Chen Khuan Wong, Cindy J. Lee, Sandra Cohen , et al. · 2020

In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR)-dependence due to lineage plasticity, which has become more prevalent, leads to clinically highly aggressive tumors with few therapeutic options and is mech…

CNCDatabase: a database of non-coding cancer drivers Open

Eric Minwei Liu, Alexander Martinez‐Fundichely, Rajesh Bollapragada, Maurice Spiewack, Ekta Khurana · 2020

Most mutations in cancer genomes occur in the non-coding regions with unknown impact on tumor development. Although the increase in the number of cancer whole-genome sequences has revealed numerous putative non-coding cancer drivers, their…

Eric Minwei Liu YOU? Author Swipe