Minwei Yang
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View article: Serum microRNA-24-based nomogram predicts prognosis for patients with resected pancreatic cancer
Serum microRNA-24-based nomogram predicts prognosis for patients with resected pancreatic cancer Open
View article: TMEM105 modulates disulfidptosis and tumor growth in pancreatic cancer via the β-catenin-c-MYC-GLUT1 axis
TMEM105 modulates disulfidptosis and tumor growth in pancreatic cancer via the β-catenin-c-MYC-GLUT1 axis Open
Background: Pancreatic cancer (PCa) is one of the most malignant diseases in the world. Different from ferroptosis and apoptosis, disulfidptosis is a novel type of cell death. The role of disulfidptosis in PCa remains uncovered. …
View article: Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma
Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma Open
Chemotherapy resistance has been a great challenge in pancreatic ductal adenocarcinoma(PDAC) treatments. Current first-line chemotherapy regimens for PDAC include gemcitabine-based regimens such as AG regimen (albumin paclitaxel and gemcit…
View article: Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study
Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study Open
A panel of four serum miRNAs was developed showing remarkably discriminative ability of early stage PCa from either healthy controls or other pancreatic diseases, suggesting it may be developed as a novel, noninvasive approach for early sc…
View article: Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma.
Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma. Open
Chemotherapy resistance has been a great challenge in pancreatic ductal adenocarcinoma (PDAC) treatments. Current first-line chemotherapy regimens for PDAC include gemcitabine-based regimens such as AG regimen (albumin paclitaxel and gemci…
View article: Development of a serum-based miRNA signature for early detection of pancreatic cancer: a multicenter cohort study
Development of a serum-based miRNA signature for early detection of pancreatic cancer: a multicenter cohort study Open
Background A grim prognosis of pancreatic cancer (PCa) was attributed to the difficulty in early diagnosis of the disease. Identifying novel biomarkers for early detection of PCa is thus urgent to improve the overall survival rates of pati…
View article: Identification of a novel immune checkpoint molecule V-set immunoglobulin domain-containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma
Identification of a novel immune checkpoint molecule V-set immunoglobulin domain-containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma Open
Background Checkpoint-based immunotherapy has failed to elicit responses in the majority of patients with pancreatic cancer. In our study, we aimed to identify the role of a novel immune checkpoint molecule V-set Ig domain-containing 4 (VS…
View article: Figure S1-7,Table S1-3 from IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer
Figure S1-7,Table S1-3 from IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer Open
Figure S1.Flow cytometry analysis of IL-22RA1 expression among PDAC; Figure S2. The correlation analyses between IL-22RA1 and CSCs Figure S3. IL-22RA1hi pancreatic cancer cells have CSCs properties Figure S4. IL-22RA1hi pancreatic cancer c…
View article: Data from IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer
Data from IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer Open
Chronic inflammation is a feature of pancreatic cancer, but little is known about how immune cells or immune cell–related signals affect pancreatic cancer stemness and development. Our previous work showed that IL22/IL22RA1 plays a vital r…
View article: Data from IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer
Data from IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer Open
Chronic inflammation is a feature of pancreatic cancer, but little is known about how immune cells or immune cell–related signals affect pancreatic cancer stemness and development. Our previous work showed that IL22/IL22RA1 plays a vital r…
View article: Figure S1-7,Table S1-3 from IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer
Figure S1-7,Table S1-3 from IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer Open
Figure S1.Flow cytometry analysis of IL-22RA1 expression among PDAC; Figure S2. The correlation analyses between IL-22RA1 and CSCs Figure S3. IL-22RA1hi pancreatic cancer cells have CSCs properties Figure S4. IL-22RA1hi pancreatic cancer c…
View article: Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma
Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma Open
View article: Identification of a novel immune checkpoint molecule V‐set immunoglobulin domain‐containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma
Identification of a novel immune checkpoint molecule V‐set immunoglobulin domain‐containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma Open
Background Checkpoint-based immunotherapy has failed to elicit responses in the majority of patients with pancreatic cancer. In our study, we aimed to identify the role of a novel immune checkpoint molecule V-set Ig domain-containing 4 (VS…
View article: Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL‐6 trans‐signalling
Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL‐6 trans‐signalling Open
Objectives This study investigated the specific molecular mechanism and the roles of extracellular matrix protein Spondin 1 (SPON1) in the development of pancreatic ductal adenocarcinoma (PDAC). Materials and Methods The expression pattern…
View article: Co-evolution of tumor cells and hepatocytes fostered by SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma
Co-evolution of tumor cells and hepatocytes fostered by SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma Open
To explore the mechanism of co-evolution and potential driver of which in pancreatic ductal adenocarcinoma (PDAC) metastasis to liver, we studied key molecules involved in this progress and their translational values. Pre-metastatic niche …
View article: SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis
SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis Open
Hot spot gene mutations in splicing factor 3b subunit 1 ( SF3B1 ) are observed in many types of cancer and create abundant aberrant mRNA splicing, which is profoundly implicated in tumorigenesis. Here, we identified that the SF3B1 K700E (S…
View article: Author response for "SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis"
Author response for "SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis" Open
View article: Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics
Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics Open
View article: Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis
Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis Open
View article: Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma
Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma Open
View article: Additional file 2 of Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma
Additional file 2 of Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma Open
Additional file 2: Table S2. Somatic mutation list.
View article: Additional file 3 of Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma
Additional file 3 of Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma Open
Additional file 3: Table S3. Significantly altered CNA regions.
View article: Molecular markers associated with perineural invasion in pancreatic ductal adenocarcinoma
Molecular markers associated with perineural invasion in pancreatic ductal adenocarcinoma Open
Perineural invasion (PNI) is a prominent characteristic of pancreatic ductal adenocarcinoma (PDAC). PNI is associated with tumor progression, local recurrence and neuropathic pain; therefore, the identification of biomarkers associated wit…
View article: Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer
Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer Open
Rationale: Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) is an endoplasmic reticulum (ER) luminal glycoprotein that has a role in the formation of disulfide bonds of secreted proteins and membrane proteins. Emerging data iden…
View article: CD74 Promotes Perineural Invasion of Cancer Cells and Mediates Neuroplasticity Via the AKT/EGR-1/GDNF Axis in Pancreatic Ductal Adenocarcinoma
CD74 Promotes Perineural Invasion of Cancer Cells and Mediates Neuroplasticity Via the AKT/EGR-1/GDNF Axis in Pancreatic Ductal Adenocarcinoma Open
View article: Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1
Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1 Open
Hypoxia and the hypovascular tumor microenvironment are major hallmarks of pancreatic ductal adenocarcinoma (PDAC), in which glycolysis is of great importance to tumor survival and proliferation. There is little research regarding the role…
View article: DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma
DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating cancer types despite the improvement of modern medicine. In our present study, we found that dickkopf-related protein 2 (DKK2) shares a higher expression in PDAC c…
View article: Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas
Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas Open
Our data demonstrated for the first time that high expression of PD-L1 in G-NECs is associated with a poor prognosis, while the high expression may be due to the copy number variation of PD-L1 gene or stimulation of TILs. These results pro…
View article: SFRP4 is a prognostic marker and correlated with Treg cell infiltration in pancreatic ductal adenocarcinoma.
SFRP4 is a prognostic marker and correlated with Treg cell infiltration in pancreatic ductal adenocarcinoma. Open
Secreted Frizzled-Related Protein 4 (SFRP4), a member of secreted frizzled-related protein family, has been found as a vital modulator in cell proliferation, cell self-renew and apoptosis through Wnt signaling transduction pathway. In the …
View article: Preparation of LiFePO4/C Cathode Materials via a Green Synthesis Route for Lithium-Ion Battery Applications
Preparation of LiFePO4/C Cathode Materials via a Green Synthesis Route for Lithium-Ion Battery Applications Open
In this work, LiFePO4/C composite were synthesized via a green route by using Iron (III) oxide (Fe2O3) nanoparticles, Lithium carbonate (Li2CO3), glucose powder and phosphoric acid (H3PO4) solution as raw materials. The reaction principles…