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View article: Large‐Scale Flat Silk Cocoons as a Highly Effective Salt‐Resistant Low‐Cost Solar‐Powered Evaporator
Large‐Scale Flat Silk Cocoons as a Highly Effective Salt‐Resistant Low‐Cost Solar‐Powered Evaporator Open
Solar seawater evaporators are a promising sustainable solution for freshwater production, yet they face challenges related to efficiency, evaporation rate, salt resistance, and the large‐scale manufacturing of evaporative materials. Here,…
View article: Magnetic Multifunctional Nanoparticles for Effective Targeted Cancer Therapy
Magnetic Multifunctional Nanoparticles for Effective Targeted Cancer Therapy Open
Due to the lack of targeting specificity, rapid clearance, and high toxicity associated with small molecule drugs in tumor treatment, the design of an effective drug delivery system is crucial. To better overcome physiological barriers and…
Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from <i>Alternaria Species</i> Open
The tetramic acid moiety is a pivotal structural unit in numerous natural products. As an analogue of the simplest tetramic acid compound tenuazonic acid (TeA), sec‐pentyl‐TeA (S‐TeA) exhibits double herbicidal activity of TeA. Here, this …
View article: Achieving significant mechanical improvement of chitosan aerogel with embedding or bridging structures mediated by size-dependent silk microfibers
Achieving significant mechanical improvement of chitosan aerogel with embedding or bridging structures mediated by size-dependent silk microfibers Open
Building high-performance aerogels with biomass-derived rather than fossil-derived polymers is an eco-friendlier option given the increasingly serious sustainability issues. Chitosan (CS) aerogels with oriented pore structures exhibit broa…
View article: The Kinetics of Mesophyll Conductance and Photorespiration During Light Induction
The Kinetics of Mesophyll Conductance and Photorespiration During Light Induction Open
Mesophyll conductance to CO2 (gm) act as a significant limiting factor influencing the CO2 assimilation rate (AN) during photosynthetic induction. However, the effect of vapor pressure deficit (VPD) on gm kinetics during light induction is…
View article: Injectable platelet-mimicking silk protein-peptide conjugate microspheres for hemostasis modulation and targeted treatment of internal bleeding
Injectable platelet-mimicking silk protein-peptide conjugate microspheres for hemostasis modulation and targeted treatment of internal bleeding Open
Uncontrolled deep bleeding, commonly encountered in surgical procedures, combat injuries, and trauma, poses a significant threat to patient survival and recovery. The development of effective hemostatic agents capable of precisely targetin…
View article: Oriented Cortical‐Bone‐Like Silk Protein Lamellae Effectively Repair Large Segmental Bone Defects in Pigs
Oriented Cortical‐Bone‐Like Silk Protein Lamellae Effectively Repair Large Segmental Bone Defects in Pigs Open
Assembling natural proteins into large, strong, bone‐mimetic scaffolds for repairing bone defects in large‐animal load‐bearing sites remain elusive. Here this challenge is tackled by assembling pure silk fibroin (SF) into 3D scaffolds with…
Continuous 1D single crystal growth with high aspect ratio by oriented aggregation of dendrite Open
Continuous 1D growth of crystals is among one of the long-standing goals in material science. Classical generic methods for 1D crystal growth such as guided disposition restrict side growth by external bounding, and become difficult as the…
View article: Tumor‐Homing Phage Nanofibers for Nanozyme‐Enhanced Targeted Breast Cancer Therapy
Tumor‐Homing Phage Nanofibers for Nanozyme‐Enhanced Targeted Breast Cancer Therapy Open
Photodynamic therapy (PDT) eliminates cancer cells by converting endogenous oxygen into reactive oxygen species (ROS). However, its efficacy is significantly hindered by hypoxia in solid tumors. Hence, to engineer filamentous fd phage, a h…
View article: Precision Treatment of Colon Cancer Using Doxorubicin-Loaded Metal–Organic-Framework-Coated Magnetic Nanoparticles
Precision Treatment of Colon Cancer Using Doxorubicin-Loaded Metal–Organic-Framework-Coated Magnetic Nanoparticles Open
Due to the limited efficacy and evident side effects of traditional chemotherapy drugs attributed to their lack of specificity and selectivity, novel strategies are essential for improving cancer treatment outcomes. Here, we successfully e…
Electrochemical Mineralization Regulates Hydroxyapatite Deposition of Silk Fibroin Nanofibers for Promoting Osteogenic Differentiation of Human Mesenchymal Stem Cells Open
Scaffold and stem cells are the key elements in the procedure of bone repair. Bombyx mori silk fibroin (SF) is the proper material for bone tissue engineering due to its biocompatibility and its easy to obtain nanofiber structure. The suit…
View article: Injectable Phage-Loaded Microparticles Effectively Release Phages to Kill Methicillin-Resistant <i>Staphylococcus aureus</i>
Injectable Phage-Loaded Microparticles Effectively Release Phages to Kill Methicillin-Resistant <i>Staphylococcus aureus</i> Open
The increasing prevalence of bacterial multidrug antibiotic resistance has led to a serious threat to public health, emphasizing the urgent need for alternative antibacterial therapeutics. Lytic phages, a class of viruses that selectively …
View article: From common biomass materials to high-performance tissue engineering scaffold: Biomimetic preparation, properties characterization, in vitro and in vivo evaluations
From common biomass materials to high-performance tissue engineering scaffold: Biomimetic preparation, properties characterization, in vitro and in vivo evaluations Open
Converting common biomass materials to high-performance biomedical products could not only reduce the environmental pressure associated with the large-scale use of synthetic materials, but also increase the economic value. Chitosan as a ve…
View article: Injectable Bombyx mori (B. mori) silk fibroin/MXene conductive hydrogel for electrically stimulating neural stem cells into neurons for treating brain damage
Injectable Bombyx mori (B. mori) silk fibroin/MXene conductive hydrogel for electrically stimulating neural stem cells into neurons for treating brain damage Open
Brain damage is a common tissue damage caused by trauma or diseases, which can be life-threatening. Stem cell implantation is an emerging strategy treating brain damage. The stem cell is commonly embedded in a matrix material for implantat…
View article: Payload‐free protein nanoparticles target inflamed colons to restore intestinal barrier integrity for effectively treating inflammatory bowel diseases
Payload‐free protein nanoparticles target inflamed colons to restore intestinal barrier integrity for effectively treating inflammatory bowel diseases Open
Anti‐inflammatory compounds, delivered as a payload to the gastrointestinal tract (GIT) by carriers, still cannot treat inflammatory bowel diseases without avoiding side effects. Here, we developed payload‐free protein nanoparticles (PNPs)…
Carbon Nanotubes Facilitate Silk Hierarchical Assembly by Dry Drawing Open
Biologically derived hierarchical structural materials not only boast energy‐efficient processing but also exhibit impressive mechanical performance. Silk stands as the gold standard in hierarchical fiber production, leveraging a unique co…
View article: Injectable Bombyx mori (B.mori) silk fibroin/MXene conductive hydrogel for electrically stimulating neural stem cells into neurons for treating brain damage
Injectable Bombyx mori (B.mori) silk fibroin/MXene conductive hydrogel for electrically stimulating neural stem cells into neurons for treating brain damage Open
Brain damage is a common tissue damage caused by trauma or diseases, which can be life-threatening. Stem cell implantation is an emerging strategy treating brain damage. The stem cell is commonly embedded in a matrix material for implantat…
View article: Development of magnetic nanoparticles with double silica shells of different porosities for efficient siRNA delivery to breast cancer cells
Development of magnetic nanoparticles with double silica shells of different porosities for efficient siRNA delivery to breast cancer cells Open
Silica-based magnetic nanoparticles are designed to deliver siRNA to triple negative breast cancer cells. The cells are killed due to siRNA-induced apoptosis upon the magnetic field-enhanced efficient cellular uptake and endosome escape of…
View article: Biomimetic Nucleation of Manganese Oxide on Silk Fibroin Nanoparticles for Designing Raspberry‐Structured Tumor Environment‐Responsive Anticancer Nanocarriers
Biomimetic Nucleation of Manganese Oxide on Silk Fibroin Nanoparticles for Designing Raspberry‐Structured Tumor Environment‐Responsive Anticancer Nanocarriers Open
Bombyx mori silk fibroin is a natural biomacromolecule that can be assembled into nanoparticles. Manganese dioxide (MnO 2 ) is responsive to tumor microenvironment (TME). Herein, SF and MnO 2 is integrated to develop novel TME‐responsive d…
View article: Metal−Organic Frameworks Nucleated by Silk Fibroin and Modified with Tumor‐Targeting Peptides for Targeted Multimodal Cancer Therapy
Metal−Organic Frameworks Nucleated by Silk Fibroin and Modified with Tumor‐Targeting Peptides for Targeted Multimodal Cancer Therapy Open
Multimodal therapy requires effective drug carriers that can deliver multiple drugs to specific locations in a controlled manner. Here, the study presents a novel nanoplatform constructed using zeolitic imidazolate framework‐8 ( Z IF‐8), a…
View article: Peptide‐Enabled Thrombus‐Targeting Nanoparticles for Highly Effective Targeted CT Imaging and Eradication of Thrombi
Peptide‐Enabled Thrombus‐Targeting Nanoparticles for Highly Effective Targeted CT Imaging and Eradication of Thrombi Open
Thrombotic disease poses a significant threat to human health as it blocks blood vessels and leads to severe symptoms. Effective treatment requires targeted therapy and precise localization of the thrombus, but traditional drugs are limite…
View article: Graphene Oxide-Coated Patterned Silk Fibroin Films Promote Cell Adhesion and Induce Cardiomyogenic Differentiation of Human Mesenchymal Stem Cells
Graphene Oxide-Coated Patterned Silk Fibroin Films Promote Cell Adhesion and Induce Cardiomyogenic Differentiation of Human Mesenchymal Stem Cells Open
Cardiac tissue engineering is a promising strategy for the treatment of myocardial damage. Mesenchymal stem cells (MSCs) are extensively used in tissue engineering. However, transformation of MSCs into cardiac myocytes is still a challenge…
Evaluating the Impact of Social Determinants on Health Prediction in the Intensive Care Unit Open
Social determinants of health (SDOH) -- the conditions in which people live, grow, and age -- play a crucial role in a person's health and well-being. There is a large, compelling body of evidence in population health studies showing that …
Association between dietary approaches to stop hypertension eating pattern and lung cancer risk in 98,459 participants: results from a large prospective study Open
Background Dietary approaches to stop hypertension (DASH) eating pattern is linked to anti-inflammatory responses and antioxidation, which overlap with the pathogenesis of lung cancer. However, there is insufficient epidemiological evidenc…
Enhanced Cancer Imaging and Chemo‐Photothermal Combination Therapy by Cancer‐Targeting Bismuth‐Based Nanoparticles Open
Due to the complexity and heterogeneity of cancer, the clear and accurate tumor imaging and image‐guided multimodal synergistic therapy are highly in demand. Here, bismuth (Bi)‐based mesoporous‐silica‐coated nanoparticles (BMSNs) are succe…
Upconversion nanoparticle-based aptasensor for rapid and ultrasensitive detection of <i>Staphylococcus aureus</i> by low-speed centrifugation Open
A novel UCNP-based aptasensor for rapid and ultrasensitive detection of Staphylococcus aureus by low-speed centrifugation, with the detecting range from 6.36 × 10 2 to 6.36 × 10 7 CFU mL −1 .
Work situation of patients with stroke who have returned to work: a scoping review protocol Open
Introduction The incidence of stroke in working-age adults is increasing. Many patients face cognitive, emotional and physical impairments and their subsequent influences on returning to work. An increasing number of studies have been cond…