Minying Zhang
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View article: Exercise effects on the link between inflammation, metabolic health and hyperuricemia: a prospective cohort study
Exercise effects on the link between inflammation, metabolic health and hyperuricemia: a prospective cohort study Open
Higher systemic inflammation, adiposity, and impaired lipid and glucose metabolism significantly increase hyperuricemia risk, particularly in early-onset cases. Exercise as interventions may reduce the levels of these risk factors, especia…
View article: Telomere-to-telomere genome assembly of Phoxinus lagowskii
Telomere-to-telomere genome assembly of Phoxinus lagowskii Open
As an important economic and ecological fish, Amur minnow (Phoxinus lagowskii) plays a significant role in food products as well as evolutionary, ecological research. However, a high-quality chromosome-level genome of P. lagowskii is not c…
View article: A retrospective cross-sectional study of association between triglyceride-glucose index and carotid atherosclerosis
A retrospective cross-sectional study of association between triglyceride-glucose index and carotid atherosclerosis Open
Background The triglyceride-glucose (TyG) index, a simple surrogate marker of insulin resistance (IR), has been associated with cardiovascular risk factors and atherosclerosis. However, its relationship with carotid atherosclerosis (CA), i…
View article: STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures
STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures Open
Background: Strong binding between T cell receptors (TCRs) and peptide–HLA (pHLA) complexes is important for triggering the adaptive immune response. Binding specificity prediction, identifying which TCRs will bind strongly to which pHLAs,…
View article: Triglyceride-glucose index and its additive interaction with <i>ABCG2/SLC2A9</i> polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study
Triglyceride-glucose index and its additive interaction with <i>ABCG2/SLC2A9</i> polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study Open
The impact of genetic predisposition on hyperuricemia was significantly greater among individuals with a higher TyG index. Over 50% of the increased risk can be attributed to the interaction, indicating a crucial synergy between genetic fa…
View article: A high-quality chromosome-level genome assembly of the topmouth culter (Culter alburnus Basilewsky, 1855)
A high-quality chromosome-level genome assembly of the topmouth culter (Culter alburnus Basilewsky, 1855) Open
View article: Interleukin-27 is positively correlated with obesity and a decrease in insulin resistance after weight loss
Interleukin-27 is positively correlated with obesity and a decrease in insulin resistance after weight loss Open
IL-27 was positively correlated with obesity, HOMA-IR, 1/HISI, Adipo-IR, and HOMA-AD. IL-27 levels significantly decreased after weight loss.
View article: Immunoprotective Efficacy Evaluation of Ompts Subunit Vaccine Against Aeromonas Hydrophila Infection in Megalobrama Amblycephala
Immunoprotective Efficacy Evaluation of Ompts Subunit Vaccine Against Aeromonas Hydrophila Infection in Megalobrama Amblycephala Open
View article: pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding
pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding Open
SUMMARY Profiling the binding of T cell receptors (TCRs) of T cells to antigenic peptides presented by MHC proteins is one of the most important unsolved problems in modern immunology. Experimental methods to probe TCR-antigen interactions…
View article: Single‐particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier
Single‐particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier Open
Bacterial extracellular vesicles (BEVs) are nano‐size particles secreted by bacteria that carry various bioactive components. These vesicles are thought to provide a new window into the mechanisms by which bacteria affect their hosts, but …
View article: Comparison of bioelectrical body and visceral fat indices and anthropometric measures in relation to type 2 diabetes by sex among Chinese adults, a cross-sectional study
Comparison of bioelectrical body and visceral fat indices and anthropometric measures in relation to type 2 diabetes by sex among Chinese adults, a cross-sectional study Open
Objectives We aim to compare the efficacies of the bioelectrical indices (percentage of body fat, PBF; visceral fat area, VFA) with the conventional anthropometric measures (body mass index, BMI; waist-hip ratio, WHR) for predicting type 2…
View article: The Screening of the Protective Antigens of Aeromonas hydrophila Using the Reverse Vaccinology Approach: Potential Candidates for Subunit Vaccine Development
The Screening of the Protective Antigens of Aeromonas hydrophila Using the Reverse Vaccinology Approach: Potential Candidates for Subunit Vaccine Development Open
The threat of bacterial septicemia caused by Aeromonas hydrophila infection to aquaculture growth can be prevented through vaccination, but differences among A. hydrophila strains may affect the effectiveness of non-conserved subunit vacci…
View article: Correction: The visceral fat area to leg muscle mass ratio is significantly associated with the risk of hyperuricemia among women: a cross-sectional study
Correction: The visceral fat area to leg muscle mass ratio is significantly associated with the risk of hyperuricemia among women: a cross-sectional study Open
View article: Ratio of visceral fat area to body fat mass (VBR) is a superior predictor of coronary heart disease
Ratio of visceral fat area to body fat mass (VBR) is a superior predictor of coronary heart disease Open
To the Editor: Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality globally, with coronary heart disease (CHD) exhibiting the highest mortality rate. Obesity is an important risk factor for cardiometabolic compl…
View article: Supplementary Figure 5 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter
Supplementary Figure 5 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter Open
Detection of HVEM expression by flow cytometry in B16 OVA or B16 F10 cell lines.
View article: Supplementary Figure 4 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter
Supplementary Figure 4 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter Open
Greatly attenuated recall response in OT-1 BTLA KO T cells in response to immunization with OVA peptide SIINFEKL.
View article: Supplementary Figure 6 from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice
Supplementary Figure 6 from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice Open
PDF file - 82K, Administration of PLX4720 in vivo increases tumor infiltration of adoptively transferred T cells and enhances antitumor responses
View article: Data from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice
Data from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice Open
Purpose: Treatment of melanoma patients with selective BRAF inhibitors results in objective clinical responses in the majority of patients with BRAF-mutant tumors. However, resistance to these inhibitors develops within a few…
View article: Supplementary Figures 1 - 7 from A New Approach to Simultaneously Quantify Both TCR α- and β-Chain Diversity after Adoptive Immunotherapy
Supplementary Figures 1 - 7 from A New Approach to Simultaneously Quantify Both TCR α- and β-Chain Diversity after Adoptive Immunotherapy Open
PDF file, 264K, Supplementary Fig. S1. TCR Va and Vb gene expression in total RNA from TILs patient 303 and patient 232. Supplementary Fig S2. Global measurement of TCR Va (A-C) and TCR Vb (D-F) gene expression in patient 231 including in …
View article: Supplementary Table 4 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter
Supplementary Table 4 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter Open
RPPA data of mouse OT-1 T cells expressing WT BTLA or BTLA variants stimulated with anti-CD3 and HVEM-FC
View article: Movie 2 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter
Movie 2 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter Open
Movie 2 from Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter
View article: Supplementary Figure 6 from Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma
Supplementary Figure 6 from Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma Open
PDF file, 99K, Four separate TAF lines were derived from human melanoma tumor biopsies and exposed overnight to recombinant human IL-1α (1 ng/ml) or IFN-γ (500 U/ml). TAFs were then stained using antibodies specific for PD-L1 and PD-L2, an…
View article: Supplementary Figure 3 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter
Supplementary Figure 3 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter Open
Expression of BTLA in human CD8+ T cells according to differentiation status.
View article: Supplementary Figure 4 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter
Supplementary Figure 4 from Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter Open
Greatly attenuated recall response in OT-1 BTLA KO T cells in response to immunization with OVA peptide SIINFEKL.
View article: Supplementary Figures 1 - 7 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients
Supplementary Figures 1 - 7 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients Open
PDF file - 1856K, Fig. S1. Schema of TIL adoptive cell therapy clinical trial; Fig. S2. Recovery of total white blood cell counts (WBC), absolute lymphocyte counts (ALC), and absolute neutrophil counts (ANC) during adoptive transfer TIL th…
View article: Supplementary Figure 3 from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice
Supplementary Figure 3 from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice Open
PDF file - 491K, Administration of PLX4720 in vivo increases tumor infiltration of adoptively transferred T cells
View article: Supplementary Table 2 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients
Supplementary Table 2 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients Open
PDF file - 69K, Derivation of the irRC best overall score
View article: Supplementary Figure 1 from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice
Supplementary Figure 1 from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice Open
PDF file - 31K, PLX4720 enhances MART-1-specific T-cell recognition of BRAF mutant melanomas
View article: Supplementary Methods from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients
Supplementary Methods from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients Open
PDF file - 115K
View article: Supplementary Figure Legend from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice
Supplementary Figure Legend from BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice Open
PDF file - 95K