Miodrag Čolić
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View article: Photobiomodulation Meets Mechanotransduction: Immune-Stromal Crosstalk in Orthodontic Remodeling
Photobiomodulation Meets Mechanotransduction: Immune-Stromal Crosstalk in Orthodontic Remodeling Open
Orthodontic tooth movement (OTM) arises from force-induced mechanotransduction within the periodontal ligament (PDL), which coordinates osteoblast and osteoclast activity with immune responses to remodel the PDL and alveolar bone. This rev…
View article: Photobiomodulation Meets Mechanotransduction: Immune and Cellular Cross-Talk during Orthodontic Tooth Movement
Photobiomodulation Meets Mechanotransduction: Immune and Cellular Cross-Talk during Orthodontic Tooth Movement Open
Orthodontic tooth movement (OTM) is governed by a highly coordinated cascade of cellular and molecular events triggered by mechanical forces. At the heart of this process lies the dynamic interplay between osteoblasts, osteoclasts, periodo…
View article: Inhibition of neutrophil oxidative burst and NETosis by fullerene-like inorganic tungsten disulfide nanoparticles with preservation of cell viability
Inhibition of neutrophil oxidative burst and NETosis by fullerene-like inorganic tungsten disulfide nanoparticles with preservation of cell viability Open
<p><strong>Introduction. </strong>Tungsten disulfide (WS₂) nanoparticles possess unique physicochemical properties, making them promising candidates for biomedical applications. While previous studies have demonstrated th…
View article: Ivy Leaf Dry Extract EA 575® Is a Potent Immunomodulator Acting on Dendritic Cells
Ivy Leaf Dry Extract EA 575® Is a Potent Immunomodulator Acting on Dendritic Cells Open
Background/Objectives: Ivy leaf extract has been shown to alleviate bronchial infection symptoms through various mechanisms, including anti-inflammatory effects. However, its impact on adaptive immunity, particularly dendritic cell (DC)/T-…
View article: Ivy Leaf Dry Extract EA 575 is a Potent Immunomodulator Acting on Dendritic Cells
Ivy Leaf Dry Extract EA 575 is a Potent Immunomodulator Acting on Dendritic Cells Open
Ivy leaf extract has been shown to alleviate bronchial infection symptoms through various mechanisms, including anti-inflammatory effects. However, its impact on adaptive immunity, particularly dendritic cell (DC)/T-cell interactions, rema…
View article: Biodentine Stimulates Calcium-Dependent Osteogenic Differentiation of Mesenchymal Stromal Cells from Periapical Lesions
Biodentine Stimulates Calcium-Dependent Osteogenic Differentiation of Mesenchymal Stromal Cells from Periapical Lesions Open
Biodentine, a tricalcium silicate cement, has emerged as a retrograde root-end filling material to promote periapical lesion (PL) healing after apicoectomy. However, its underlying mechanisms remain unclear. This study tested the hypothesi…
View article: Biodentine Stimulates Calcium-Dependent Osteogenic Differentiation of Mesenchymal Stromal Cells from Periapical Lesions
Biodentine Stimulates Calcium-Dependent Osteogenic Differentiation of Mesenchymal Stromal Cells from Periapical Lesions Open
Biodentine, a tricalcium silicate cement, has emerged as a retrograde root-end filling material to promote periapical lesion (PL) healing after apicoectomy. However, its underlying mechanisms remain unclear. This study tested the hypothesi…
View article: Anti-Inflammatory and Immunomodulatory Properties of Inorganic Fullerene-Like Tungsten Disulfide Nanoparticles in the Culture of Human Peripheral Blood Mononuclear Cells
Anti-Inflammatory and Immunomodulatory Properties of Inorganic Fullerene-Like Tungsten Disulfide Nanoparticles in the Culture of Human Peripheral Blood Mononuclear Cells Open
Tungsten disulfide (WS2) nanoparticles have emerged in the biomedical field as potential theranostic agents due to their unique properties, including biocompatibility. However, their impact on the immune response remains unexplored. This s…
View article: Production of chemokines by mesenchymal stromal cells established from inflamed human gingiva and its modulation by lipopolysaccharide
Production of chemokines by mesenchymal stromal cells established from inflamed human gingiva and its modulation by lipopolysaccharide Open
<p><strong>Introduction. </strong>The role of gingiva-derived stromal cells (GMSCs) in chronic periodontitis is poorly understood. Since GMSCs modulate the inflammatory and immune responses this study aimed to investigate…
View article: Dapsone Alters Phenotypical and Functional Properties of Human Neutrophils In Vitro
Dapsone Alters Phenotypical and Functional Properties of Human Neutrophils In Vitro Open
Dapsone is a sulfone used in treating inflammatory skin conditions. Despite its widespread dermatological use, the pharmacological actions of dapsone remain poorly understood. Here, we examined how different aspects of neutrophil functions…
View article: Editorial: Myeloid-derived suppressor cells in health and diseases: harnessing their roles in the development of new immunotherapy approaches
Editorial: Myeloid-derived suppressor cells in health and diseases: harnessing their roles in the development of new immunotherapy approaches Open
Editorial: Myeloid-derived suppressor cells in health and diseases: harnessing their roles in the development of new immunotherapy approaches
View article: Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats
Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats Open
Bacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocyte…
View article: Cytotoxicity and anti-inflammatory properties of a GLP-1 receptor agonist in a model of human peripheral blood mononuclear cell culture
Cytotoxicity and anti-inflammatory properties of a GLP-1 receptor agonist in a model of human peripheral blood mononuclear cell culture Open
<p><strong>Introduction. </strong>GLP-1R agonists (GLP-1RAs) are a type of anti-hyperglycemic medications used for the management of type 2 diabetes mellitus (T2DM). In addition to glucose-lowering effects, GLP-1R agonist…
View article: Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats
Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats Open
Bacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocyte…
View article: Exogenous α-ketoglutarate Modulates Redox Metabolism and Functions of Human Dendritic Cells, Altering Their Capacity to Polarise T Cell Response
Exogenous α-ketoglutarate Modulates Redox Metabolism and Functions of Human Dendritic Cells, Altering Their Capacity to Polarise T Cell Response Open
Alpha-ketoglutarate (αKG) emerged as a key regulator of energetic and redox metabolism in cells, affecting the immune response in various conditions. However, it remained unclear how the exogenous αKG modulates the functions of dendritic c…
View article: Sitagliptin Induces Tolerogenic Human Dendritic Cells
Sitagliptin Induces Tolerogenic Human Dendritic Cells Open
Sitagliptin, an anti-diabetic drug, is a dipeptidyl peptidase (DPP)-4/CD26 inhibitor with additional anti-inflammatory and immunomodulatory properties. In this study, we investigated for the first time the effect of sitagliptin on the diff…
View article: Pomegranate Peel Extract Differently Modulates Gene Expression in Gingiva-Derived Mesenchymal Stromal Cells under Physiological and Inflammatory Conditions
Pomegranate Peel Extract Differently Modulates Gene Expression in Gingiva-Derived Mesenchymal Stromal Cells under Physiological and Inflammatory Conditions Open
Pomegranate has shown a favorable effect on gingivitis/periodontitis, but the mechanisms involved are poorly understood. The aim of this study was to test the effect of pomegranate peel extract (PoPEx) on gingiva-derived mesenchymal stroma…
View article: Immunomodulatory activity of dipeptidyl peptidase‐4 inhibitors in immune‐related diseases
Immunomodulatory activity of dipeptidyl peptidase‐4 inhibitors in immune‐related diseases Open
Dipeptidyl peptidase‐4 (DPP‐4), also known as CD26, is a 110‐kDa cell surface glycoprotein with enzymatic and signal transducing activity. DPP‐4/CD26 is expressed by various cells, including CD4+ and CD8+ T cells, B cells, dendritic cells,…
View article: A Laser Synthesis Route to Boron‐Doped Gold Nanoparticles Designed for X‐Ray Radiotherapy and Boron Neutron Capture Therapy Assisted by CT Imaging
A Laser Synthesis Route to Boron‐Doped Gold Nanoparticles Designed for X‐Ray Radiotherapy and Boron Neutron Capture Therapy Assisted by CT Imaging Open
New multifunctional theranostic vectors allow the expansion of cancer therapeutic approaches toward scarcely investigated fields. One example is the combination of boron neutron capture therapy (BNCT) and X‐ray radiotherapy (XRT) for treat…
View article: Dysfunctions of Neutrophils in the Peripheral Blood of Children with Cystic Fibrosis
Dysfunctions of Neutrophils in the Peripheral Blood of Children with Cystic Fibrosis Open
Dysfunction of neutrophils in patients with cystic fibrosis (CF) is best characterized in bronchoalveolar lavage (BAL), whereas peripheral blood neutrophils are less examined, and the results are contradictory, especially in younger popula…
View article: Periodontal Disease in Young Adults as a Risk Factor for Subclinical Atherosclerosis: A Clinical, Biochemical and Immunological Study
Periodontal Disease in Young Adults as a Risk Factor for Subclinical Atherosclerosis: A Clinical, Biochemical and Immunological Study Open
Although a strong relationship between periodontal disease (PD) and atherosclerosis was shown in adults, little data are published in younger PD patients. Therefore, this study aimed to investigate and correlate clinical parameters of PD, …
View article: The Role of Nucleases Cleaving TLR3, TLR7/8 and TLR9 Ligands, Dicer RNase and miRNA/piRNA Proteins in Functional Adaptation to the Immune Escape and Xenophagy of Prostate Cancer Tissue
The Role of Nucleases Cleaving TLR3, TLR7/8 and TLR9 Ligands, Dicer RNase and miRNA/piRNA Proteins in Functional Adaptation to the Immune Escape and Xenophagy of Prostate Cancer Tissue Open
The prototypic sensors for the induction of innate and adaptive immune responses are the Toll-like receptors (TLRs). Unusually high expression of TLRs in prostate carcinoma (PC), associated with less differentiated, more aggressive and mor…
View article: Immunomodulatory Activity of Punicalagin, Punicalin, and Ellagic Acid Differs from the Effect of Pomegranate Peel Extract
Immunomodulatory Activity of Punicalagin, Punicalin, and Ellagic Acid Differs from the Effect of Pomegranate Peel Extract Open
Background: Our recent study has shown that pomegranate peel extract (PEx) showed significant immunomodulatory activity, which might be caused by ellagitannins. The aim of this work was to test the hypothesis that ellagitannin components a…
View article: Phosphonate-Modified Cellulose Nanocrystals Potentiate the Th1 Polarising Capacity of Monocyte-Derived Dendritic Cells via GABA-B Receptor
Phosphonate-Modified Cellulose Nanocrystals Potentiate the Th1 Polarising Capacity of Monocyte-Derived Dendritic Cells via GABA-B Receptor Open
The delivery of ApA via CNCs induces potent DC-mediated Th1 polarisation, which could be beneficial in their potential application in tumour therapy.
View article: Immunomodulatory Properties of Pomegranate Peel Extract in a Model of Human Peripheral Blood Mononuclear Cell Culture
Immunomodulatory Properties of Pomegranate Peel Extract in a Model of Human Peripheral Blood Mononuclear Cell Culture Open
Pomegranate peel extract (PoPEx) has been shown to have antioxidant and anti-inflammatory properties, but its effect on the adaptive immune system has not been sufficiently investigated. In this study, the treatment of human peripheral blo…
View article: Cellulose Nanocrystals as a Versatile Platform for Regulation of Myeloid Cell Immunogenicity
Cellulose Nanocrystals as a Versatile Platform for Regulation of Myeloid Cell Immunogenicity Open
Phosphonates possess a great potential for the therapy of bone tumours due to their inhibitory potential for osteoclasts. The delivery of phosphonates via cellulose nanocrystals (CNCs) seems a promising approach for their increased efficac…
View article: Mesenchymal Stromal Cells from Healthy and Inflamed Human Gingiva Respond Differently to Porphyromonas gingivalis
Mesenchymal Stromal Cells from Healthy and Inflamed Human Gingiva Respond Differently to Porphyromonas gingivalis Open
Gingiva-Derived Mesenchymal Stromal Cells (GMSCs) have been shown to play an important role in periodontitis. However, how P. gingivalis, one of the key etiological agents of the disease, affects healthy (H)- and periodontitis (P)-GMSCs is…
View article: Harnessing immunomodulatory mechanisms of Trichinella spiralis to design novel nanomedical approaches for restoring self-tolerance in autoimmunity
Harnessing immunomodulatory mechanisms of Trichinella spiralis to design novel nanomedical approaches for restoring self-tolerance in autoimmunity Open
The rapid increase in the prevalence of autoimmune diseases in recent decades, especially in developed countries, coincided with improved living conditions and healthcare. Part of this increase could be ascribed to the lack of exposure to …
View article: Inclusivity and diversity: Integrating international perspectives on stem cell challenges and potential
Inclusivity and diversity: Integrating international perspectives on stem cell challenges and potential Open
View article: Antimicrobial properties of viscose yarns ring-spun with integrated amino-functionalized nanocellulose
Antimicrobial properties of viscose yarns ring-spun with integrated amino-functionalized nanocellulose Open
Bio-based, renewable and biodegradable products with multifunctional properties are also becoming basic trends in the textile sector. In this frame, cellulose nanofibrils (CNFs) have been surface modified with hexamethylenediamine/HMDA and…