Miodrag Janić
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View article: Overall hemostatic potential as a marker of subclinical hypercoagulability in treated psoriasis patients
Overall hemostatic potential as a marker of subclinical hypercoagulability in treated psoriasis patients Open
Background Psoriasis is associated with increased cardiovascular risk, possibly mediated by inflammation-induced hemostatic dysregulation and hypercoagulability. However, these changes are often difficult to detect with conventional marker…
View article: Machine learning and deep learning in diabetology: revolutionizing diabetes care
Machine learning and deep learning in diabetology: revolutionizing diabetes care Open
View article: Obesity: Recent Advances and Future Perspectives
Obesity: Recent Advances and Future Perspectives Open
As reported in the World Obesity Atlas 2024 by the World Obesity Federation, the projections for 2035 suggest that more than 1 [...]
View article: Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study
Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study Open
View article: Diabetes: Recent Advances and Future Perspectives
Diabetes: Recent Advances and Future Perspectives Open
Diabetes is a chronic metabolic disorder distinguished by persistent hyperglycemia [...]
View article: Potential Use of GLP-1 and GIP/GLP-1 Receptor Agonists for Respiratory Disorders: Where Are We at?
Potential Use of GLP-1 and GIP/GLP-1 Receptor Agonists for Respiratory Disorders: Where Are We at? Open
Chronic respiratory disorders are the third leading cause of mortality globally. Consequently, there is a continuous pursuit of effective therapies beyond those currently available. The therapeutic potential of the glucagon-like peptide-1 …
View article: Novel antidiabetic therapies in patients with peripheral artery disease: current perspective
Novel antidiabetic therapies in patients with peripheral artery disease: current perspective Open
View article: Glucometabolic Efficacy of the Empagliflozin/Metformin Combination in People with Type 1 Diabetes and Increased Cardiovascular Risk: A Sub-Analysis of a Pilot Randomized Controlled Trial
Glucometabolic Efficacy of the Empagliflozin/Metformin Combination in People with Type 1 Diabetes and Increased Cardiovascular Risk: A Sub-Analysis of a Pilot Randomized Controlled Trial Open
Background/Objectives: People with type 1 diabetes have an unmet need for cardiovascular protection due to the lack of new recommended antidiabetic therapies with cardiovascular benefits. We examined whether the addition of an empagliflozi…
View article: The Role of Lipid Metabolism in Dyslipidemias and Atherosclerosis
The Role of Lipid Metabolism in Dyslipidemias and Atherosclerosis Open
Atherosclerotic cardiovascular disease is a major burden of morbidity and, despite recent therapeutic advances, is the leading cause of mortality worldwide [...]
View article: Arterial function is preserved in successfully treated patients with psoriasis vulgaris
Arterial function is preserved in successfully treated patients with psoriasis vulgaris Open
Introduction Endothelial dysfunction is an early precursor of atherosclerosis and is common in patients with psoriasis, presumably primarily due to psoriasis-related inflammation. We investigated endothelial function, arterial stiffness, a…
View article: Residual metabolic burden in young psoriasis patients successfully treated with biologics
Residual metabolic burden in young psoriasis patients successfully treated with biologics Open
Metabolic disorders are common in patients with psoriasis and contribute significantly to an increased cardiovascular risk. While biologic therapy is very successful in clearing skin lesions, its impact on metabolic parameters is uncertain…
View article: Residual metabolic burden in young psoriasis patients successfully treated with biologics
Residual metabolic burden in young psoriasis patients successfully treated with biologics Open
Metabolic disorders are common in patients with psoriasis and contribute significantly to an increased cardiovascular risk. While biologic therapy is very successful in clearing skin lesions, its impact on metabolic parameters is uncertain…
View article: Obesity and Insulin Resistance in Asthma Pathogenesis and Clinical Outcomes
Obesity and Insulin Resistance in Asthma Pathogenesis and Clinical Outcomes Open
Common inflammatory ground links obesity, insulin resistance, and asthma. As recognition of their interplay, one worsening the natural course of the other, is recognised, questions remain about how to adequately address them altogether to …
View article: Diabetična ketoacidoza: redek, a resen zaplet zdravljenja z zaviralci SGLT-2 – pregled literature in prikaz serije primerov
Diabetična ketoacidoza: redek, a resen zaplet zdravljenja z zaviralci SGLT-2 – pregled literature in prikaz serije primerov Open
Zaviralci natrij-glukoznega koprenašalnega sistema-2 (SGLT-2) se vse pogosteje predpisujejo tako v diabetologiji kot tudi v drugih internističnih strokah. Primarno ugodno vplivajo na presnovne dejavnike, tj. parametre glikemije in na teles…
View article: Efficacy, safety, and patient satisfaction with oral semaglutide: first single-centre clinical experience
Efficacy, safety, and patient satisfaction with oral semaglutide: first single-centre clinical experience Open
Objective To explore the effects of oral semaglutide on glycaemic parameters, body weight, and satisfaction in the first recipient patients with type 2 diabetes mellitus in Slovenia, in a real-world clinical practice setting. Methods The f…
View article: Luskavica skozi prizmo prizadetosti srčno-žilnega sistema
Luskavica skozi prizmo prizadetosti srčno-žilnega sistema Open
Luskavica je kronična sistemska vnetna bolezen. Sistemsko vnetje pri luskavici vodi v številne pridružene bolezni, med katerimi so srčno-žilne bolezni glavni vzrok obolevnosti in umrljivosti. Ker zaenkrat presejanje na prisotnost dejavniko…
View article: Killing Two Birds with One Stone: Potential Therapies Targeting Psoriasis and Atherosclerosis at the Same Time
Killing Two Birds with One Stone: Potential Therapies Targeting Psoriasis and Atherosclerosis at the Same Time Open
Psoriasis is a chronic systemic inflammatory disease. Due to systemic inflammation, it is associated with many comorbidities. Among them, cardiovascular diseases represent the most common causes of morbidity and mortality in this populatio…
View article: Empagliflozin-Metformin Combination Has Antioxidative and Anti-Inflammatory Properties that Correlate with Vascular Protection in Adults with Type 1 Diabetes
Empagliflozin-Metformin Combination Has Antioxidative and Anti-Inflammatory Properties that Correlate with Vascular Protection in Adults with Type 1 Diabetes Open
Background and Aim. Our previous study showed that the empagliflozin-metformin combination significantly improved arterial function; i.e., it improved endothelial function (measured by flow-mediated dilation and reactive hyperaemia index) …
View article: Effect of Oral Semaglutide on Cardiovascular Parameters and Their Mechanisms in Patients with Type 2 Diabetes: Rationale and Design of the Semaglutide Anti-Atherosclerotic Mechanisms of Action Study (SAMAS)
Effect of Oral Semaglutide on Cardiovascular Parameters and Their Mechanisms in Patients with Type 2 Diabetes: Rationale and Design of the Semaglutide Anti-Atherosclerotic Mechanisms of Action Study (SAMAS) Open
View article: Obravnava bolnikov s sladkorno boleznijo v času epidemije covida-19
Obravnava bolnikov s sladkorno boleznijo v času epidemije covida-19 Open
Leto 2020 bo nedvomno zaznamovano s pandemijo koronavirusne bolezni 2019 (covid-19), ki jo povzroča novi koronavirus SARS-CoV-2. Izkazalo se je, da pri bolnikih s sladkorno boleznijo covid-19 poteka v hujši obliki; v večjem deležu je potre…
View article: Treating Arterial Ageing in Patients with Diabetes: From Mechanisms to Effective Drugs
Treating Arterial Ageing in Patients with Diabetes: From Mechanisms to Effective Drugs Open
Diabetes mellitus is a major healthcare problem. It is not only characterized by hyperglycemia and chronic complications, but in longer lasting diabetes and a longer living population, it is also associated with accelerated arterial ageing…
View article: Expression of Longevity Genes Induced by a Low-Dose Fluvastatin and Valsartan Combination with the Potential to Prevent/Treat “Aging-Related Disorders”
Expression of Longevity Genes Induced by a Low-Dose Fluvastatin and Valsartan Combination with the Potential to Prevent/Treat “Aging-Related Disorders” Open
The incidence of aging-related disorders may be decreased through strategies influencing the expression of longevity genes. Although numerous approaches have been suggested, no effective, safe, and easily applicable approach is yet availab…
View article: Molecular Mechanisms Responsible for Diastolic Dysfunction in Diabetes Mellitus Patients
Molecular Mechanisms Responsible for Diastolic Dysfunction in Diabetes Mellitus Patients Open
In diabetic patients, cardiomyopathy is an important cause of heart failure, but its pathophysiology has not been completely understood thus far. Myocardial hypertrophy and diastolic dysfunction have been considered the hallmarks of diabet…
View article: Problematika uživanja pijač z dodanim sladkorjem v Sloveniji in svetu
Problematika uživanja pijač z dodanim sladkorjem v Sloveniji in svetu Open
Pojavnost kardiometabolnih bolezni je dosegla pandemične razsežnosti, zato se čedalje večja pozornost posveča tudi z življenjskim slogom pogojenemu zdravju prebivalstva, še posebej načinu prehranjevanja in vnosu določenih skupin živil. Šte…
View article: Empagliflozin on top of metformin treatment improves arterial function in patients with type 1 diabetes mellitus
Empagliflozin on top of metformin treatment improves arterial function in patients with type 1 diabetes mellitus Open
Background Deteriorated arterial function and high incidence of cardiovascular events characterise diabetes mellitus. Metformin and recent antidiabetic drugs, SGLT2 inhibitors, reduce cardiovascular events. We explored the possible effects…
View article: Zaviralci SGLT-2
Zaviralci SGLT-2 Open
Zaviralci natrij-glukoznega prenašalnega sistema 2 (SGLT-2) so najnovejša skupina zdravil za zdravljenje sladkorne bolezni tipa 2, ki so v klinični uporabi zadnjih nekaj let. V proksimalnih tubulih ledvic zmanjšajo reabsorpcijo glukoze, ki…
View article: Preprečevanje venskih trombembolizmov pri internističnih bolnikih v bolnišnici
Preprečevanje venskih trombembolizmov pri internističnih bolnikih v bolnišnici Open
Background: Venous thromboembolism (VTE) is the most common unpredictable cause of in-hospital death. Despite the fact that VTE prophylaxis has been proven to be efficacious and safe it remains underused. The aim is to determine the use of …
View article: Metformin: od mehanizmov delovanja do napredne klinične uporabe
Metformin: od mehanizmov delovanja do napredne klinične uporabe Open
Metformin represents the first line of treatment and is the most widely prescribed antihypergycemic drug in type 2 diabetic patients. It can be used as monotherapy or in combination with other oral antihyperglycemic drugs or insulin. Addit…
View article: Metformin: from mechanisms of action to advanced clinical use
Metformin: from mechanisms of action to advanced clinical use Open
Metformin represents the first line of treatment and is the most widely prescribed antihypergycemic drug in type 2 diabetic patients. It can be used as monotherapy or in combination with other oral antihyperglycemic drugs or insulin. Addit…
View article: Long-term improvement of arterial wall characteristics in patients with diabetes mellitus type 1 using cyclic, intermittent treatment with a low-dose fluvastatin and valsartan combination
Long-term improvement of arterial wall characteristics in patients with diabetes mellitus type 1 using cyclic, intermittent treatment with a low-dose fluvastatin and valsartan combination Open
Improvement of arterial wall (AW) characteristics decreases cardiovascular risk. In a previous study, it was observed that AW characteristics in patients with diabetes mellitus type 1 are significantly improved by short-term treatment with…