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High levels of serum cholesterol increase the risk of developing vessel co‐opting tumors in colorectal cancer liver metastases Open

Amatzia Gantz, Audrey Kapelanski‐Lamoureux, Miran Rada, Lucyna Krzywoń, Migmar Tsamchoe , et al. · 2025

Cholesterol availability has been implicated in cancer progression. Here, we demonstrate the connection between blood cholesterol concentration, the development of distinct histopathological growth patterns (HGPs) in colorectal cancer live…

Bruton’s Tyrosine Kinase: A Double-Edged Sword in Cancer and Aging Open

Zahraa Qusairy, Miran Rada · 2025

Bruton’s tyrosine kinase (BTK) is a key signaling molecule involved in both hematological malignancies and solid tumors. In B-cell malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL), BTK mediates B-cell …

Bruton's Tyrosine Kinase: A Double-Edged Sword in Cancer and Aging Open

Zahraa Qusairy, Miran Rada · 2025

Bruton's tyrosine kinase (BTK) is a key signaling molecule involved in both hematological malignancies and solid tumors. In B-cell malignancies such as Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin Lymphoma (NHL), BTK mediates B-…

International Biospecimen Sourcing Platform: A Key Player in Advancing Health Research and Drug Discovery Open

Zahraa Qusairy, Miran Rada · 2023

The field of biobanking human biospecimens has evolved significantly, transitioning from the basic, often poorly documented collection of clinical leftovers kept privately to well-organized and extensively documented collections overseen b…

Inhibition of proprotein convertase subtilisin-like kexin type 9 (PCSK9) potentiates anti-angiogenic therapy in colorectal cancer liver metastases Open

Miran Rada, Andrew R. Reynolds, Anthoula Lazaris, Nabil G. Seidah, Peter Metrakos · 2023

Colorectal cancer liver metastatic (CRCLM) tumours present as two main histopathological growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP (RHGP). The DHGP tumours obtain their blood supply by sprouting angiogene…

Transforming Growth Factor-Beta 1 Induces Neutrophil Apoptosis in Colorectal Cancer Liver Metastases Open

Miran Rada, Migmar Tsamchoe, Jessica de Bloom, Diane Kim, Stephanie Petrillo , et al. · 2023

Vessel co-option correlates with resistance against anti-angiogenic agents and chemotherapy in colorectal cancer liver metastasis (CRCLM). We previously identified higher intensity of neutrophils in the tumour microenvironment of vessel co…

Figure S2 from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

Supplementary Figure 2. p53 phosphorylation.

Legends from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

Legends for supplementary figures

Figure S3 from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

Supplementary Figure 3. BTK and apoptosis.

Figure S1 from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

Supplementary Figure 1.p53 expression and phosphorylation.

Legends from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

Legends for supplementary figures

Figure S3 from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

Supplementary Figure 3. BTK and apoptosis.

Figure S2 from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

Supplementary Figure 2. p53 phosphorylation.

Data from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

p53 is a tumor suppressor that prevents the emergence of transformed cells by inducing apoptosis or senescence, among other responses. Its functions are regulated tightly by posttranslational modifications. Here we show that Bruton's tyros…

Data from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

p53 is a tumor suppressor that prevents the emergence of transformed cells by inducing apoptosis or senescence, among other responses. Its functions are regulated tightly by posttranslational modifications. Here we show that Bruton's tyros…

Figure S1 from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses Open

Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb , et al. · 2023

Supplementary Figure 1.p53 expression and phosphorylation.

A Retrospective Study on the Role of Metformin in Colorectal Cancer Liver Metastases Open

Miran Rada, Lucyna Krzywoń, Stephanie Petrillo, Anthoula Lazaris, Peter Metrakos · 2023

Colorectal cancer liver metastases (CRCLMs) have two main histopathological growth patterns (HPGs): desmoplastic (DHGP) and replacement (RHGP). The vascularization in DHGP tumours is angiogenic, while the RHGP tumours exert vessel co-optio…

Vitamin D supplementation improves the prognosis of patients with colorectal cancer liver metastases Open

Miran Rada, Lucyna Krzywoń, Audrey Kapelanski-Lamoureux, Diane Kim, Stephanie Petrillo , et al. · 2022

Colorectal cancer liver metastasis (CRCLM) is one of the deadliest cancers. CRCLM tumours have two distinct histopathological growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP (RHGP). The DHGP tumours are angioge…

The molecular mechanisms underlying neutrophil infiltration in vessel co-opting colorectal cancer liver metastases Open

Miran Rada, Nour Hassan, Anthoula Lazaris, Peter Metrakos · 2022

Colorectal cancer liver metastases (CRCLMs) have two major histopathological growth patterns (HGPs): desmoplastic (DHGP) and replacement (RHGP). The DHGP tumours derive their vasculature by angiogenesis, while the RHGP tumours use vessel c…

Angiopoietin-1 Upregulates Cancer Cell Motility in Colorectal Cancer Liver Metastases through Actin-Related Protein 2/3 Open

Miran Rada, Audrey Kapelanski-Lamoureux, Migmar Tsamchoe, Stephanie Petrillo, Anthoula Lazaris , et al. · 2022

Resistance to anti-angiogenic therapy is a major challenge in the treatment of colorectal cancer liver metastases (CRCLMs). Vessel co-option has been identified as a key contributor to anti-angiogenic therapy resistance in CRCLMs. Recently…

Cancer Cells Promote Phenotypic Alterations in Hepatocytes at the Edge of Cancer Cell Nests to Facilitate Vessel Co-Option Establishment in Colorectal Cancer Liver Metastases Open

Miran Rada, Migmar Tsamchoe, Audrey Kapelanski-Lamoureux, Nour Hassan, Jessica Bloom , et al. · 2022

Vessel co-option is correlated with resistance against anti-angiogenic therapy in colorectal cancer liver metastases (CRCLM). Vessel co-opting lesions are characterized by highly motile cancer cells that move toward and along the pre-exist…

Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases Open

Miran Rada, Audrey Kapelanski-Lamoureux, Stephanie Petrillo, Sébastien Tabariès, Peter M. Siegel , et al. · 2021

Cancer cells induce hepatocytes apoptosis in co-opted colorectal cancer liver metastatic lesions Open

Miran Rada, Migmar Tsamchoe, Audrey Kapelanski-Lamoureux, Jessica Bloom, Stephanie Petrillo , et al. · 2021

Vessel co-option in colorectal cancer liver metastases (CRCLM) has been recognized as one of the mechanistic pathways that contribute to resistance against anti-angiogenic therapy. In vessel co-opted CRCLM lesions, the cancer cells are hig…

Severity of Coronavirus Disease 2019 in Patients with Cancer Open

Zahraa Qusairy, Miran Rada · 2020

The outbreak of the novel coronavirus disease 2019 (COVID-19) has appeared to be one of the biggest global health threats worldwide with no specific therapeutic agents. As of August 2020, over 22.4 million confirmed cases and more than 788…

Relevance of the Bruton Tyrosine Kinase as a Target for COVID-19 Therapy Open

Miran Rada, Zahraa Qusairy, Marta Massip‐Salcedo, Salvador Macip · 2020

The outbreak of the novel coronavirus disease 2019 (COVID-19) has emerged as one of the biggest global health threats worldwide. As of October 2020, more than 44 million confirmed cases and more than 1,160,000 deaths have been reported glo…

Tumor microenvironment conditions that favor vessel co-option in colorectal cancer liver metastases: A theoretical model Open

Miran Rada, Anthoula Lazaris, Audrey Kapelanski-Lamoureux, Thomas Z. Mayer, Peter Metrakos · 2020

Vessel co-option is an alternative strategy by which tumour cells vascularize and gain access to nutrients to support tumour growth, survival and metastasis. In vessel co-option, the cancer cells move towards the pre-existing vasculature a…

Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer Open

Sameera Nallanthighal, Miran Rada, James Patrick Heiserman, Jennifer Cha, Jessica Sage , et al. · 2020

Collagen type XI alpha 1 (COL11A1) is a novel biomarker associated with cisplatin resistance in ovarian cancer. However, the mechanisms underlying how COL11A1 confers cisplatin resistance in ovarian cancer are poorly understood. We identif…

Angiopoietin1 Deficiency in Hepatocytes Affects the Growth of Colorectal Cancer Liver Metastases (CRCLM) Open

Nisreen Ibrahim, Anthoula Lazaris, Miran Rada, Stephanie Petrillo, Laurent Huck , et al. · 2019

Colorectal cancer liver metastases (CRCLM) that receive their blood supply via vessel co-option are associated with a poor response to anti-angiogenic therapy. Angiopoietins (Ang1 and Ang2) with their Tyrosine-protein kinase receptor (Tie2…

Amelioration of age‐related brain function decline by Bruton's tyrosine kinase inhibition Open

Akang E. Ekpenyong‐Akiba, Marta Poblocka, Mohammad Althubiti, Miran Rada, Diana Jurk , et al. · 2019

One of the hallmarks of aging is the progressive accumulation of senescent cells in organisms, which has been proposed to be a contributing factor to age‐dependent organ dysfunction. We recently reported that Bruton's tyrosine kinase (BTK)…

BTK: a two-faced effector in cancer and tumour suppression Open

Miran Rada, Nickolai A. Barlev, Salvador Macip · 2018

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