Miranda Kirchner
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View article: Diversity of antimicrobial resistance and virulence genes of pathogenic Escherichia coli recovered from pigs in England
Diversity of antimicrobial resistance and virulence genes of pathogenic Escherichia coli recovered from pigs in England Open
Introduction We characterised the genomes of 208 pathogenic Escherichia coli isolated from pigs diagnosed with enteric colibacillosis (EC), bowel oedema (BO) or colisepticaemia (CS) in England between 2016–2020 to investigate their antimic…
View article: Streptococcus hepaticus sp. nov. isolated from the liver of domestic pigs (Sus scrofa domesticus)
Streptococcus hepaticus sp. nov. isolated from the liver of domestic pigs (Sus scrofa domesticus) Open
A Gram-positive coccus-shaped bacterium, which could not be identified by classical determinative bacteriology approaches, was isolated from the liver of two pigs in the United Kingdom. Initial testing based on cellular morphology and bioc…
View article: Use of transcriptomics and genomics to assess the effect of disinfectant exposure on the survival and resistance of Escherichia coli O157:H7, a human pathogen
Use of transcriptomics and genomics to assess the effect of disinfectant exposure on the survival and resistance of Escherichia coli O157:H7, a human pathogen Open
Disinfectants are essential for biosecurity, preventing the persistence and spread of zoonotic pathogens on farms and subsequent human infections. In this study, transcriptomics and genomics were utilised to assess the effect of disinfecta…
View article: Rapid detection and molecular epidemiology of β-lactamase producing Enterobacteriaceae isolated from food animals and in-contact humans in Nigeria
Rapid detection and molecular epidemiology of β-lactamase producing Enterobacteriaceae isolated from food animals and in-contact humans in Nigeria Open
The emergence and spread of β-lactamase-producing Enterobacteriaceae poses a significant threat to public health, necessitating the rapid detection and investigation of the molecular epidemiology of these pathogens. We modified a multiplex…
View article: Recommendation of a standardized broth microdilution method for antimicrobial susceptibility testing of <i>Avibacterium paragallinarum</i> and resistance monitoring
Recommendation of a standardized broth microdilution method for antimicrobial susceptibility testing of <i>Avibacterium paragallinarum</i> and resistance monitoring Open
This study aimed to develop a method for standardized broth microdilution antimicrobial susceptibility testing (AST) of Avibacterium ( Av .) paragallinarum , the causative agent of infectious coryza in chickens. For this, a total of 83 Av.…
View article: Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria Open
The rise in antimicrobial resistance (AMR) in bacteria is reducing therapeutic options for livestock and human health, with a paucity of information globally. To fill this gap, a One-Health approach was taken by sampling livestock on farms…
View article: A sensitive method for the recovery of <i>Escherichia coli</i> serogroup O55 including Shiga toxin‐producing variants for potential use in outbreaks
A sensitive method for the recovery of <i>Escherichia coli</i> serogroup O55 including Shiga toxin‐producing variants for potential use in outbreaks Open
Several human outbreaks reported in England were caused by STEC O55:H7. Tools developed here could assist in identification of the environmental source for these isolates, which has not yet been established.
View article: Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017
Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017 Open
An outbreak of Shiga toxin-producing Escherichia coli (STEC) O157:H7 occurred on the Isle of Wight between August and October 2017. Of the seven cases linked to the outbreak, five were identified through the statutory notification process …
View article: mcr-1 and mcr-2 (mcr-6.1) variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015
mcr-1 and mcr-2 (mcr-6.1) variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015 Open
Our results add further evidence for the mobilization of the mcr-pap2 unit from Moraxella via composite transposons leading to its global dissemination. The presence of mcr-pap2 from recent Moraxella isolates indicates they may comprise a …
View article: Occurrence and characterization of<i>mcr-1-</i>harbouring<i>Escherichia coli</i>isolated from pigs in Great Britain from 2013 to 2015
Occurrence and characterization of<i>mcr-1-</i>harbouring<i>Escherichia coli</i>isolated from pigs in Great Britain from 2013 to 2015 Open
mcr-1- harbouring plasmids were diverse, implying transposable elements are involved in mcr-1 transmission in GB. The low number of mcr-1 -positive E. coli isolates identified suggested mcr-1 is currently uncommon in E. coli from pigs with…
View article: Impact of Ciprofloxacin and Clindamycin Administration on Gram-Negative Bacteria Isolated from Healthy Volunteers and Characterization of the Resistance Genes They Harbor
Impact of Ciprofloxacin and Clindamycin Administration on Gram-Negative Bacteria Isolated from Healthy Volunteers and Characterization of the Resistance Genes They Harbor Open
The aim of this study was to assess the impact of ciprofloxacin, clindamycin, and placebo administration on culturable Gram-negative isolates and the antibiotic resistance genes they harbor. Saliva and fecal samples were collected from hea…