Miranda M. Lim
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View article: Neurotype matching in monogamous rodents is modulated by early-life sleep experience
Neurotype matching in monogamous rodents is modulated by early-life sleep experience Open
Studies of human sociability indicate stronger social affinity in matched-neurotype dyads (e.g., two individuals with autism or two without) compared to mixed-neurotype dyads (e.g., one individual with autism paired with one without). Is t…
View article: Post-traumatic stress disorder and REM-sleep behavior disorder: exploring genetic associations and causal links
Post-traumatic stress disorder and REM-sleep behavior disorder: exploring genetic associations and causal links Open
Objective To explore potential genetic and/or causal associations between Post-Traumatic Stress Disorder and neurodegeneration-related isolated/idiopathic rapid-eye-movement sleep behavior disorder. Methods We conducted polygenic risk scor…
View article: Developmental time course of social touch, parvalbumin interneurons, perineuronal nets and Mef2c expression reveals a sensitive period of somatosensory cortex development in prairie voles
Developmental time course of social touch, parvalbumin interneurons, perineuronal nets and Mef2c expression reveals a sensitive period of somatosensory cortex development in prairie voles Open
Social touch facilitates our attachment to others, especially early in life, which may be linked to the maturation of parvalbumin interneurons (PVI) in the somatosensory cortex (S1). These neurons respond to social touch, mature in a senso…
View article: A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans
A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans Open
View article: 0147 Nocturnal Blood Pressure as an Emerging Biosignal in Sleep
0147 Nocturnal Blood Pressure as an Emerging Biosignal in Sleep Open
Introduction Sleep blood pressure (BP) is an important cardiovascular marker. A sporadic BP measurement by traditional oscillometric ambulatory BP monitoring cannot capture dynamic BP fluctuation occurring in sleep. Acute BP surges accompa…
View article: 0407 Behavioral and Pharmacological Interventions to Improve Social Affiliation in Prairie Voles Exposed to Early Life Sleep Disruption
0407 Behavioral and Pharmacological Interventions to Improve Social Affiliation in Prairie Voles Exposed to Early Life Sleep Disruption Open
Introduction Rapid eye movement (REM) sleep peaks early in life and may represent a sensitive period for proper maturation of the neurobiological systems underlying the development of complex social behaviors. Prairie voles (Microtus ochro…
View article: 0417 Preclinical Model to Test Potential Therapeutics to Prevent Phenoconversion of REM Sleep Behavior Disorder to Parkinson’s Disease After Neurotrauma
0417 Preclinical Model to Test Potential Therapeutics to Prevent Phenoconversion of REM Sleep Behavior Disorder to Parkinson’s Disease After Neurotrauma Open
Introduction Neurotrauma, including traumatic brain injury (TBI) and/or post-traumatic stress disorder (PTSD), often results in persistent sleep disturbances and impaired neurological function. This includes an increased frequency for REM …
View article: 1283 SLEEPoVER Protocol: A Fully Remote, Multimodal Sleep Phenotyping Package to Benchmark Disease Progression and Response to Therapy
1283 SLEEPoVER Protocol: A Fully Remote, Multimodal Sleep Phenotyping Package to Benchmark Disease Progression and Response to Therapy Open
Introduction Previous work supports sleep disturbances as a benchmark of disease progression. To understand this relationship between sleep and health, efforts are emerging to observe sleep in clinical populations and to test sleep therapi…
View article: 1290 Amino Acid Supplementation Improves Sleep in Older Adults with Traumatic Brain Injury at Risk for Neurodegeneration
1290 Amino Acid Supplementation Improves Sleep in Older Adults with Traumatic Brain Injury at Risk for Neurodegeneration Open
Introduction Older adults with a history of traumatic brain injury (TBI) are more likely to experience chronic sleep disturbances and cognitive impairments, elevating their risk of future neurodegeneration. Interventions to mitigate sleep …
View article: 1191 Increased Rate of Dementia in PTSD Is Reduced by Alpha-1-antagonist Prazosin to Treat Nightmares: A Retrospective Study of Veteran Medical Records
1191 Increased Rate of Dementia in PTSD Is Reduced by Alpha-1-antagonist Prazosin to Treat Nightmares: A Retrospective Study of Veteran Medical Records Open
Introduction Adults with post-traumatic stress disorder (PTSD) have a significantly increased risk for developing dementia. With previous work linking sleep-related glymphatic dysfunction to neurodegeneration, sleep disturbances in PTSD ar…
View article: 1297 OSA Is Associated with Increased Incidence of Parkinson’s Disease and Is Mitigated by CPAP Treatment
1297 OSA Is Associated with Increased Incidence of Parkinson’s Disease and Is Mitigated by CPAP Treatment Open
Introduction Prior work has demonstrated an association between Obstructive Sleep Apnea (OSA) and development of Parkinson’s Disease (PD), but these studies were limited by small sample size, limited duration, confounding by large-effect c…
View article: 1282 Morning Bright Light Therapy Improves Sleep and Systemic Inflammatory Profiles in Veterans and Non-Veterans with or Without Traumatic Brain Injury
1282 Morning Bright Light Therapy Improves Sleep and Systemic Inflammatory Profiles in Veterans and Non-Veterans with or Without Traumatic Brain Injury Open
Introduction Sleep-wake disturbances frequently present in Veterans with mild traumatic brain injury (mTBI). These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. Therapies to i…
View article: Heart rate variability impairment during sleep in Veterans with rapid eye movement sleep behaviour disorder, traumatic brain injury, and post‐traumatic stress disorder: an early potential window into autonomic dysfunction?
Heart rate variability impairment during sleep in Veterans with rapid eye movement sleep behaviour disorder, traumatic brain injury, and post‐traumatic stress disorder: an early potential window into autonomic dysfunction? Open
Summary Individuals with comorbid rapid eye movement (REM) sleep behaviour disorder (RBD) and neurotrauma (NT; defined by traumatic brain injury and post‐traumatic stress disorder) have an earlier age of RBD symptom onset, increased RBD‐re…
View article: SmART-TBI: A fully remote protocol for a randomized placebo-controlled double-blinded clinical trial for a dietary supplement to improve sleep in Veterans
SmART-TBI: A fully remote protocol for a randomized placebo-controlled double-blinded clinical trial for a dietary supplement to improve sleep in Veterans Open
Traumatic brain injury (TBI) is associated with chronic sleep disturbances and cognitive impairment, with limited effective therapeutic strategies. Our previous work showed dietary supplementation with branched chain amino acids (BCAAs; is…
View article: <i>Centella asiatica</i> improves sleep quality and quantity in aged mice
<i>Centella asiatica</i> improves sleep quality and quantity in aged mice Open
Age-related sleep disruption is common in older adults. Not only does the total amount of time spent in sleep decline, but the number of arousals during sleep increases with age. As sleep is important for both memory consolidation and to p…
View article: Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol
Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol Open
Sleep-wake disturbances frequently present in Veterans with mild traumatic brain injury (mTBI). These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. Therapies to improve sleep …
View article: Effects of Traumatic Brain Injury on the Orexin/Hypocretin System
Effects of Traumatic Brain Injury on the Orexin/Hypocretin System Open
Traumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. One neuropeptide system has been studied repeatedly as a potential cause of sleep disruptions after …
View article: <i>Centella asiatica</i> improves sleep quality and quantity in aged mice
<i>Centella asiatica</i> improves sleep quality and quantity in aged mice Open
Age-related sleep disruption is common in older adults. Not only does the total amount of time spent in sleep decline, but also the number of arousals during sleep increases with age. As sleep is important for both memory consolidation and…
View article: Understanding discrepancies between self-reported and objective sleep in adolescents and young adults with subacute concussion
Understanding discrepancies between self-reported and objective sleep in adolescents and young adults with subacute concussion Open
Study Objectives Conduct a multidimensional analysis of sleep perception, objective sleep, and neuropsychiatric wellbeing in individuals with subacute concussion compared to controls. Methods Thirty-one recently concussed individuals compl…
View article: Structural and functional connectivity of the posterior default mode network is associated with sleep disturbance rather than pain in the Twin sub-study of the MAPP Research Network
Structural and functional connectivity of the posterior default mode network is associated with sleep disturbance rather than pain in the Twin sub-study of the MAPP Research Network Open
The neurophysiological underpinnings of chronic pain and sleep disturbances, which are commonly comorbid are not well understood. Investigation of common structural and functional brain network alterations of sleep disturbance in the setti…
View article: Heart rate variability impairment during sleep in Veterans with REM sleep behavior disorder, traumatic brain injury, and posttraumatic stress disorder: An early potential window into autonomic dysfunction?
Heart rate variability impairment during sleep in Veterans with REM sleep behavior disorder, traumatic brain injury, and posttraumatic stress disorder: An early potential window into autonomic dysfunction? Open
Individuals with comorbid REM sleep behavior disorder (RBD) and neurotrauma (defined by traumatic brain injury and post-traumatic stress disorder) have an earlier age of RBD symptom onset, increased RBD-related symptom severity and more ne…
View article: IGLON5 Frequency in Idiopathic REM Sleep Behavior Disorder
IGLON5 Frequency in Idiopathic REM Sleep Behavior Disorder Open
NCT03623672.
View article: Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces
Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces Open
Background and Purpose An association recently emerged between magnetic resonance imaging (MRI)-visible perivascular spaces (MV-PVS) with intracerebral solute clearance and neuroinflammation, in adults. However, it is unknown how MV-PVS ch…
View article: Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation
Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation Open
The appearance of misfolded and aggregated proteins is a pathological hallmark of numerous neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Sleep disruption is proposed to contribute to these pathological p…
View article: The glymphatic system clears amyloid beta and tau from brain to plasma in humans
The glymphatic system clears amyloid beta and tau from brain to plasma in humans Open
Poor sleep is implicated in the development of Alzheimer’s disease (AD) pathology and cognitive impairment. Dysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and AD, and in animal models …
View article: Development of sleep and circadian rhythms: Function and dysfunction
Development of sleep and circadian rhythms: Function and dysfunction Open
View article: Quantifying social roles in multi-animal videos using subject-aware deep-learning
Quantifying social roles in multi-animal videos using subject-aware deep-learning Open
Analyzing social behaviors is critical for many fields, including neuroscience, psychology, and ecology. While computational tools have been developed to analyze videos containing animals engaging in limited social interactions under speci…
View article: Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI<sup>2</sup>sponsored protocol
Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI<sup>2</sup>sponsored protocol Open
Sleep-wake disturbances frequently present in Veterans with mild traumatic brain injury (mTBI). These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. Therapies to improve sleep …
View article: Larry J. Young (1967–2024)
Larry J. Young (1967–2024) Open
View article: Head Injury Treatment With Healthy and Advanced Dietary Supplements: A Pilot Randomized Controlled Trial of the Tolerability, Safety, and Efficacy of Branched Chain Amino Acids in the Treatment of Concussion in Adolescents and Young Adults
Head Injury Treatment With Healthy and Advanced Dietary Supplements: A Pilot Randomized Controlled Trial of the Tolerability, Safety, and Efficacy of Branched Chain Amino Acids in the Treatment of Concussion in Adolescents and Young Adults Open
Concussion is a common injury in the adolescent and young adult populations. Although branched chain amino acid (BCAA) supplementation has shown improvements in neurocognitive and sleep function in pre-clinical animal models of mild-to-mod…