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View article: Rapidly Progressive Merkel Cell Carcinoma with Atypical Metastatic Pattern—A Case Report and Brief Literature Review
Rapidly Progressive Merkel Cell Carcinoma with Atypical Metastatic Pattern—A Case Report and Brief Literature Review Open
Background and Clinical Significance: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine cutaneous malignancy with increasing incidence among elderly, immunocompromised patients or individuals exposed to ultraviolet radiation…
View article: Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets
Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets Open
Cardio-kidney-metabolic (CKM) syndrome represents an integrated clinical and molecular continuum encompassing metabolic dysfunction, cardiovascular disease and chronic kidney disease. This multidimensional disorder arises from interdepende…
View article: The impact of the COVID-19 pandemic on the cardiac rehabilitation in diabetic patients with cardiovascular comorbidities admitted in a hospital from Transylvania
The impact of the COVID-19 pandemic on the cardiac rehabilitation in diabetic patients with cardiovascular comorbidities admitted in a hospital from Transylvania Open
Diabetes Mellitus represents a global health issue with a greater risk of cardiovascular disease than non-diabetic individuals. Cardiac rehabilitation (CR) is a comprehensive program involving multiple disciplines that aims to enhance the …
View article: Electrocardiographic Changes in Patients with Type 2 Diabetes Mellitus—A Meta-Analysis
Electrocardiographic Changes in Patients with Type 2 Diabetes Mellitus—A Meta-Analysis Open
Background: Diabetes mellitus (DM) is a chronic metabolic disorder significantly associated with cardiovascular complications. Electrocardiographic (ECG) abnormalities are common in patients with type 2 diabetes (T2DM) and can serve as ear…
View article: Desmoid Tumor Management Challenges: A Case Report and Literature Review on the Watch-and-Wait Approach in Recurrent Thoracic Fibromatosis
Desmoid Tumor Management Challenges: A Case Report and Literature Review on the Watch-and-Wait Approach in Recurrent Thoracic Fibromatosis Open
Desmoid tumors are rare mesenchymal neoplasms arising from locally invasive fibroblasts. While they lack metastatic potential, they exhibit high local recurrence rates and can cause significant tissue destruction. We present the case of a …
View article: Desmoid Tumor Management Chalanges: A Case Report and Literature Review on the Watch-and-Wait Approach in Recurrent Thoracic Fibromatosis
Desmoid Tumor Management Chalanges: A Case Report and Literature Review on the Watch-and-Wait Approach in Recurrent Thoracic Fibromatosis Open
Desmoid tumors are rare mesenchymal neoplasms arising from locally invasive fibroblasts. While they lack metastatic potential, they exhibit high local recurrence rates and can cause significant tissue destruction. We present the case of a …
View article: Hepatotoxicity induced by immune checkpoint inhibitors
Hepatotoxicity induced by immune checkpoint inhibitors Open
Immune checkpoint inhibitors (ICIs) are an effective immunotherapeutic approach for cancers affecting the lung, skin, kidney, mammary gland, or certain hematologic malignancies. Regarding the prognosis of these oncological conditions, trea…
View article: Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations
Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations Open
Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, the brain’s ability to adapt its structure and function, plays a…
View article: Physical Rehabilitation in Multiple Myeloma - A Retrospective Analysis and Future Perspectives
Physical Rehabilitation in Multiple Myeloma - A Retrospective Analysis and Future Perspectives Open
Multiple Myeloma is a malignancy characterized by multisystem involvement, including multiple osteolytic lesions, anemia, and renal insufficiency. The debilitating course of this disease highlights the importance of exploring the therapeut…
View article: Obesity Control and Supplementary Nutraceuticals as Co-Factors of Brain Plasticity in Multiple Sclerosis Populations
Obesity Control and Supplementary Nutraceuticals as Co-Factors of Brain Plasticity in Multiple Sclerosis Populations Open
Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, the brain's ability to adapt its structure and function, plays a…
View article: Obesity Control and Nutraceuticals in the Aid of Brain Plasticity in Multiple Sclerosis Patients
Obesity Control and Nutraceuticals in the Aid of Brain Plasticity in Multiple Sclerosis Patients Open
Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, the brain's ability to adapt its structure and function, pl…
View article: From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases
From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases Open
Inflammatory bowel diseases (IBDs) are characterized by chronic gastrointestinal inflammation due to abnormal immune responses to gut microflora. The gut–brain axis is disrupted in IBDs, leading to neurobiological imbalances and affective …
View article: The Usefulness of Vitamin K-Dependent Proteins in the Diagnosis of Colorectal Carcinoma
The Usefulness of Vitamin K-Dependent Proteins in the Diagnosis of Colorectal Carcinoma Open
Colorectal cancer (CRC) is one of the most common neoplasms in developed countries, with increasing incidence and mortality, even in young people. A variety of serum markers have been associated with CRC (CEA, CA 19-9), but neither should …
View article: Molecular Links between Inflammatory Bowel Disease and Mild Cognitive Impairment- a Narrative Review
Molecular Links between Inflammatory Bowel Disease and Mild Cognitive Impairment- a Narrative Review Open
IBD, encompassing CD and UC, are characterized by chronic gastrointestinal inflammation due to abnormal immune responses to gut microflora. The bidirectional communication between the gut and the brain, known as the GBA, is disrupted in IB…
View article: Age-related trends in colorectal cancer diagnosis: focus on evaluation of prehabilitation and rehabilitation programs
Age-related trends in colorectal cancer diagnosis: focus on evaluation of prehabilitation and rehabilitation programs Open
The increase in the prevalence of both colon and rectal cancer in recent years poses challenges for the medical system in terms of patient management and indirectly incurs significant financial burdens. Purpose: The aim of this paper is to…
View article: The COVID-19 pandemic has revealed an increase in cancer diagnoses and a decrease in prehabilitation programs among patients in Transylvania
The COVID-19 pandemic has revealed an increase in cancer diagnoses and a decrease in prehabilitation programs among patients in Transylvania Open
Introduction: The COVID-19 pandemic has brought significant disruptions to the landscape of oncological medicine, resulting in postponed cancer diagnoses and treatments, poor implementation of prehabilitation programmes, and an overall alt…
View article: Matrix Gla Protein – a new marker for colorectal cancer detection? A systematic review
Matrix Gla Protein – a new marker for colorectal cancer detection? A systematic review Open
Background. Colorectal cancer is a real public health issue, with high morbidity and severe impact on quality of life. Although mortality from this type of cancer is decreasing due to modern diagnostic and treatment methods, the understand…
View article: Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis Open
Background and Objectives: the early diagnosis of hepatocellular carcinoma (HCC) benefits from the use of alpha-fetoprotein (AFP) together with imaging diagnosis using abdominal ultrasonography, CT, and MRI, leading to improved early detec…
View article: Paraoxonase 1 and atrial fibrillation: Is there a relationship?
Paraoxonase 1 and atrial fibrillation: Is there a relationship? Open
Atrial fibrillation (AF) is associated with oxidative stress and inflammation. Paraoxonase-1 (PON1), circulates in blood bound to high-density lipoproteins and reduces systemic oxidative stress. The aim of this study was to evaluate PON1 s…
View article: Chronic Inflammation—A Link between Nonalcoholic Fatty Liver Disease (NAFLD) and Dysfunctional Adipose Tissue
Chronic Inflammation—A Link between Nonalcoholic Fatty Liver Disease (NAFLD) and Dysfunctional Adipose Tissue Open
Nonalcoholic fatty liver disease (NAFLD) is a new challenge in modern medicine, due to its high prevalence in the world. The pathogenesis of NAFLD is a complex dysmetabolic process, following the “multiple-hit” hypothesis that involves hep…
View article: Cardiovascular Risk Factors and Physical Activity for the Prevention of Cardiovascular Diseases in the Elderly
Cardiovascular Risk Factors and Physical Activity for the Prevention of Cardiovascular Diseases in the Elderly Open
Cardiovascular diseases create an important burden on the public health systems, especially in the elderly, mostly because this group of patients frequently suffer from multiple comorbidities. Accumulating cardiovascular risk factors durin…
View article: Non-dental oral cavity findings in gastroesophageal reflux disease: a systematic review and meta-analysis
Non-dental oral cavity findings in gastroesophageal reflux disease: a systematic review and meta-analysis Open
Gastroesophageal reflux disease (GERD) is known as the most prevalent gastrointestinal disorder in the United States, leading to substantial morbidity, although associated mortality is rare. Based on the appearance of esophageal mucosa on …
View article: Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study
Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study Open
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The aim of this study was to evaluate the possible association between paraoxonase-1 (PON1), periostin (POSTN), tumor necrosis factor (TNF)-α, interleuki…
View article: The Effects of Flavonoids in Cardiovascular Diseases
The Effects of Flavonoids in Cardiovascular Diseases Open
Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation of their beneficial effects on the cardiovascular system. These favorable effects are exerted by f…
View article: Duodenal carcinoid tumour – a case report
Duodenal carcinoid tumour – a case report Open
Duodenal carcinoids are rare tumours of the small intestine with heterogenous clinical and pathological characteristics. The long-term prognosis is very good if discovered in the early stages. We present the case of a patient with a non-fu…
View article: Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease
Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease Open
Background: Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with an important antioxidant role. The aim of this study was t…
View article: Renal damage induced by non-steroidal anti-inflammatory drug treatment
Renal damage induced by non-steroidal anti-inflammatory drug treatment Open
Non-steroidal anti-inflammatory drugs (NSAIDs) are extensively used worldwide due to their analgesic, antipyretic and antiinflammatory effects. NSAIDs (both non-selective NSAIDs and selective cyclooxygenase-2 inhibitors) have nephrotoxic p…
View article: Ethical aspects of smoking cessation among the population from Transylvania
Ethical aspects of smoking cessation among the population from Transylvania Open
Ethical aspects related to the approach of persons addicted to tobacco use are a particular concern of pneumologists. Considered for a long time ”an expression of the modern way of life”, smoking is viewed today as a pandemic disease, bein…
View article: Arylesterase activity of Paraoxonase 1 - prognostic factor for one-year survival in patients with acute myocardial infarction
Arylesterase activity of Paraoxonase 1 - prognostic factor for one-year survival in patients with acute myocardial infarction Open
Introduction: Reduced serum levels of paraoxonase 1 (PON1) activities are associated with diseases involving increased oxidative stress, such as acute coronary syndrome. We aimed to determine whether serum PON1 activities are a prognostic …