Mirela Dimitrova
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View article: Orf virus-based vectors induce potent germinal center B cell, Tfh cell, and CD8+ T cell responses
Orf virus-based vectors induce potent germinal center B cell, Tfh cell, and CD8+ T cell responses Open
Recombinant Orf virus (rORFV) vectors have proven safe and immunogenic in human clinical trials but the cellular correlates of antibody induction by this parapoxviral platform remain ill-defined. To characterize antigen-specific B cell res…
View article: Chronic Infection Perturbs the Affinity Hierarchy of Antiviral B Cells
Chronic Infection Perturbs the Affinity Hierarchy of Antiviral B Cells Open
The germinal center (GC) subjects antigen-specific B cells to a Darwinian selection process. Whether and how persistent viral infection perturbs the intended affinity hierarchy remains ill-defined. Here we transferred monoclonal lymphocyti…
View article: mRNA prime-boost vaccination promotes clonal continuity in germinal center reactions and broadens SARS-CoV-2 variant coverage
mRNA prime-boost vaccination promotes clonal continuity in germinal center reactions and broadens SARS-CoV-2 variant coverage Open
mRNA- and adenovirus-based (rAd) SARS-CoV-2 vaccines have been widely used in various homologous and heterologous prime-boost combinations. It remains unknown, however, which vaccination regimens effectively promote B cell clonal continuit…
View article: Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection
Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection Open
To interrogate the role of specific immune cells in infection, cancer, and autoimmunity, immunologists commonly use monoclonal depletion antibodies (depletion-mAbs) or genetically engineered mouse models (GEMMs). To generate a tool that co…
View article: Permanent lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection
Permanent lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection Open
To interrogate the role of specific immune cells in infection, cancer and autoimmunity, immunologists commonly use monoclonal depletion antibodies (depletion-mAbs) or genetically engineered mouse models (GEMMs). To generate a tool that com…
View article: Central tolerance shapes the neutralizing B cell repertoire against a persisting virus in its natural host
Central tolerance shapes the neutralizing B cell repertoire against a persisting virus in its natural host Open
Viral mimicry of host cell structures has been postulated to curtail the B cell receptor (BCR) repertoire against persisting viruses through tolerance mechanisms. This concept awaits, however, experimental testing in a setting of natural v…
View article: Raw data to: "Vectored antibody gene delivery restores host B and T cell control of persistent viral infection"
Raw data to: "Vectored antibody gene delivery restores host B and T cell control of persistent viral infection" Open
Raw data underlying the publication by Ertuna et al. entitled "Vectored antibody gene delivery restores host B and T cell control of persistent viral infection"
View article: Raw data to: "Vectored antibody gene delivery restores host B and T cell control of persistent viral infection"
Raw data to: "Vectored antibody gene delivery restores host B and T cell control of persistent viral infection" Open
Raw data underlying the publication by Ertuna et al. entitled "Vectored antibody gene delivery restores host B and T cell control of persistent viral infection"
View article: Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection
Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection Open
Significance Vaccines against persisting viruses such as HIV or hepatitis C virus remain a significant unmet global need. Long-lived memory B cells can be induced by vaccination to form an important pillar of antiviral immunity, yet persis…
View article: Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection"
Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection" Open
Raw data underlying the publication by Narr et al. entitled "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection".
View article: Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection"
Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection" Open
Raw data underlying the publication by Narr et al. entitled "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection".
View article: Vectored antibody gene delivery restores host B and T cell control of persistent viral infection
Vectored antibody gene delivery restores host B and T cell control of persistent viral infection Open
Passive antibody therapy and vectored antibody gene delivery (VAGD) in particular offer an innovative approach to combat persistent viral diseases. Here, we exploit a small animal model to investigate synergies of VAGD with the host's endo…
View article: Characterization of the in vitro and in vivo properties of CFZ533, a blocking and non-depleting anti-CD40 monoclonal antibody
Characterization of the in vitro and in vivo properties of CFZ533, a blocking and non-depleting anti-CD40 monoclonal antibody Open