Explanipedia

Perfluorooctanoic acid induces transcriptomic alterations in second trimester human cytotrophoblasts Open

Hao Chen, Mirhan Kapidzic, Danielle Gantar, Sena Aksel, Justine Levan , et al. · 2023

Poly- and perfluroroalkylated substances (PFAS) are a major class of surfactants used in industry applications and consumer products. Despite efforts to reduce the usage of PFAS due to their environmental persistence, compounds such as per…

Proteomic analyses of primary human villous trophoblasts exposed to flame retardant BDE-47 using SWATH-MS Open

Hao Chen, Katherine Williams, Elaine Kwan, Mirhan Kapidzic, Kenisha A. Puckett , et al. · 2023

Regionally distinct trophoblast regulate barrier function and invasion in the human placenta Open

Bryan Marsh, Yan Zhou, Mirhan Kapidzic, Susan J. Fisher, Robert Blelloch · 2022

The human placenta contains two specialized regions: the villous chorion where gases and nutrients are exchanged between maternal and fetal blood, and the smooth chorion (SC) which surrounds more than 70% of the developing fetus but whose …

Author response: Regionally distinct trophoblast regulate barrier function and invasion in the human placenta Open

Bryan Marsh, Yan Zhou, Mirhan Kapidzic, Susan Fisher, Robert Blelloch · 2022

Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The human placenta con…

Regionally distinct trophoblast regulate barrier function and invasion in the human placenta Open

Bryan Marsh, Yan Zhou, Mirhan Kapidzic, Susan J. Fisher, Robert Blelloch · 2022

The human placenta contains two specialized regions: the villous chorion where gases and nutrients are exchanged between maternal and fetal blood, and the smooth chorion which surrounds more than 70% of the developing fetus but whose cellu…

RNA profiling of laser microdissected human trophoblast subtypes at mid-gestation reveals a role for cannabinoid signaling in invasion Open

Matthew Gormley, Oliver Oliverio, Mirhan Kapidzic, Katherine Ona, Steven C. Hall , et al. · 2021

Human placental architecture is complex. Its surface epithelium, specialized for transport, forms by fusion of cytotrophoblast progenitors into multinucleated syncytiotrophoblasts. Near the uterine surface, these progenitors assume a diffe…

Global proteomic analyses of human cytotrophoblast differentiation/invasion Open

Hao Chen, Katherine Williams, Elaine Kwan, Mirhan Kapidzic, Kenisha A. Puckett , et al. · 2021

During human pregnancy, cytotrophoblasts (CTBs) from the placenta differentiate into specialized subpopulations that play crucial roles in proper fetal growth and development. A subset of these CTBs differentiate along an invasive pathway,…

Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease Open

Bo Zhang, M. Yvonne Kim, GiNell Elliot, Yan Zhou, Guangfeng Zhao , et al. · 2021

Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum Open

Leah McNally, Yan Zhou, Joshua F. Robinson, Guangfeng Zhao, Lee-may Chen , et al. · 2020

Significance The syndrome of cytotrophoblast invasion beyond the normal boundary (in the superficial myometrium) is collectively termed placenta accreta spectrum. The incidence of this condition is rising. However, little is known about th…

Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNF-alpha Open

Sara Taylor, Sahar Houshdaran, Joshua F. Robinson, Matthew Gormley, Elaine Kwan , et al. · 2020

The placenta releases large quantities of extracellular vesicles (EVs) that likely facilitate communication between the embryo/fetus and the mother. We isolated EVs from second trimester human cytotrophoblasts (CTBs) by differential ultrac…

Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts Open

Joshua F. Robinson, Mirhan Kapidzic, Emily G. Hamilton, Hao Chen, Kenisha W Puckett , et al. · 2018

Despite gradual legislative efforts to phase out flame retardants (FRs) from the marketplace, polybrominated diphenyl ethers (PBDEs) are still widely detected in human maternal and fetal tissues, eg, placenta, due to their continued global…

An Investigation of the Single and Combined Phthalate Metabolite Effects on Human Chorionic Gonadotropin Expression in Placental Cells Open

Jennifer J. Adibi, Yaqi Zhao, Lei Zhan, Mirhan Kapidzic, Nicholas Larocque , et al. · 2017

Concentrations of MnBP, MBzP and MEHP similar to those found in the urine of pregnant women consistently altered hCG and PPARγ expression in primary placental cells. These findings provide evidence for the molecular basis by which phthalat…

Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology Open

Tamara Garrido‐Gómez, Francisco Domı́nguez, Alicia Quiñonero, Patricia Díaz-Gimeno, Mirhan Kapidzic , et al. · 2017

Significance We provide evidence of a decidualization defect in the endometrium of women with severe preeclampsia (PE) that was detected at the time of delivery and persisted years after the affected pregnancy. We went on to link this defe…

Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts Open

Joshua F. Robinson, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Terrence Dent , et al. · 2017

During human pregnancy, cytotrophoblasts (CTBs) play key roles in uterine invasion, vascular remodeling, and anchoring of the feto-placental unit. Due to the challenges associated with studying human placentation in utero, cultured primary…

The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation Open

Marcus O. Muench, Mirhan Kapidzic, Matthew Gormley, Alan G. Gutierrez, Kathryn L. Ponder , et al. · 2017

We examined the contribution of the fetal membranes, amnion and chorion, to human embryonic and fetal hematopoiesis. A population of cells displaying a hematopoietic progenitor phenotype (CD34++ CD45low) of fetal origin was present in the …

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface Open

Gabrielle Rizzuto, Mirhan Kapidzic, Matthew R. Gormley, Anna I. Bakardjiev · 2016

The placenta shows a large degree of interspecies anatomic variability. To best understand biology and pathophysiology of the human placenta, it is imperative to design experiments using human cells and tissues. An advantage of organ cultu…

Stromal Cell-Derived Factor 2: A Novel Protein that Interferes in Endoplasmic Reticulum Stress Pathway in Human Placental Cells Open

Aline R. Lorenzon, Cristiane Rodrigues Guzzo, Mirhan Kapidzic, Susan J. Fisher, Estela Bevilacqua · 2016

Endoplasmic reticulum (ER) stress results from changes in ER homeostasis and folding of proteins. ER stress initiates cellular adaptive mechanisms to rescue cell homeostasis or, if that does not work, to elicit apoptosis. We have previousl…

Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation Open

Olga Genbačev, Nicholas Larocque, Katherine Ona, A Prakobphol, Tamara Garrido‐Gómez , et al. · 2016

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Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche Open

Kathryn L. Ponder, Alicia Bárcena, Frank L. Bos, Matthew Gormley, Yan Zhou , et al. · 2016

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