Miriam A. Schiele
YOU?
Author Swipe
View article: Dynamic Epigenetic Changes During Antidepressant Pharmacotherapy in Major Depressive Disorder
Dynamic Epigenetic Changes During Antidepressant Pharmacotherapy in Major Depressive Disorder Open
Background Although antidepressants remain the main pharmacological treatment for major depressive disorder (MDD), therapeutic response is highly variable, highlighting the need for reliable markers that predict and mechanistically explain…
View article: DNA Methylation Signatures of Alcohol Use Disorder – A large-scale Meta-Analysis in the Psychiatric Genomics Consortium
DNA Methylation Signatures of Alcohol Use Disorder – A large-scale Meta-Analysis in the Psychiatric Genomics Consortium Open
Despite extensive research on DNA methylation (DNAm) signatures associated with alcohol use disorder (AUD), findings are often inconsistent and not replicated. We conducted a large-scale meta-analysis of epigenome-wide association studies …
View article: Psychometric Considerations in Assessing Fear Generalization as a Predictor of Anxiety
Psychometric Considerations in Assessing Fear Generalization as a Predictor of Anxiety Open
View article: Social anxiety disorder and antibodies against glial cells in the cerebrospinal fluid
Social anxiety disorder and antibodies against glial cells in the cerebrospinal fluid Open
View article: Therapygenetics: Serotonin transporter gene polymorphism (5-HTTLPR) is associated with behavioral treatment response to virtual exposure therapy in patients with spider phobia
Therapygenetics: Serotonin transporter gene polymorphism (5-HTTLPR) is associated with behavioral treatment response to virtual exposure therapy in patients with spider phobia Open
Identifying biomarkers predicting therapy outcomes before treatment holds great promise for advancing precision medicine. Genetic variants such as the serotonin transporter gene linked polymorphic region (5-HTTLPR) may be associated with r…
View article: A systematic review of methylome-wide associations with anxiety disorders
A systematic review of methylome-wide associations with anxiety disorders Open
Anxiety disorders (ANX) are a prevalent public health burden that significantly impair daily functioning and decrease quality of life. A growing body of research suggests that DNA methylation (DNAm), an epigenetic modification that can imp…
View article: Therapygenetics: Serotonin transporter gene polymorphism (<i>5-HTTLPR</i>) is associated with behavioral treatment response to virtual exposure therapy in patients with spider phobia
Therapygenetics: Serotonin transporter gene polymorphism (<i>5-HTTLPR</i>) is associated with behavioral treatment response to virtual exposure therapy in patients with spider phobia Open
Identifying biomarkers predicting therapy outcomes before treatment holds great promise for advancing precision medicine. Genetic variants such as the serotonin transporter gene linked polymorphic region ( 5-HTT LPR) may be associated with…
View article: Relationships between depersonalization-derealization symptoms and separation anxiety in adult patients with mood and anxiety disorders
Relationships between depersonalization-derealization symptoms and separation anxiety in adult patients with mood and anxiety disorders Open
Aims To establish the relationship between depersonalization/derealization symptoms (DPs), as assessed by different standardized DP scales, and separation anxiety in a sample of outpatients with anxiety and mood disorders as a primary diag…
View article: Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome
Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome Open
Epigenetic mechanisms such as DNA methylation are hypothesized to play a pivotal role in the pathogenesis of anxiety disorders and to predict as well as relate to treatment response. An epigenome-wide association study (EWAS) (Illumina Met…
View article: Obsessive–Compulsive Symptoms and Heterozygous Microduplication of the RB1CC1 Gene
Obsessive–Compulsive Symptoms and Heterozygous Microduplication of the RB1CC1 Gene Open
View article: The Adult Separation Anxiety Questionnaire (ASA-27): reliability of the German translation, factor structure, and concurrent validity with anxiety sensitivity and agoraphobic cognition
The Adult Separation Anxiety Questionnaire (ASA-27): reliability of the German translation, factor structure, and concurrent validity with anxiety sensitivity and agoraphobic cognition Open
Background Separation anxiety disorder (SEPAD) is characterized by pronounced fear or anxiety concerning separation from attachment figures. Despite its high lifetime prevalence, adult SEPAD often remains undetected due to a lack of diagno…
View article: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults
Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults Open
Childhood adversity is a strong predictor of developing psychopathological conditions. Multiple theories on the mechanisms underlying this association have been suggested which, however, differ in the operationalization of ‘exposure.’ Alte…
View article: Author response: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults
Author response: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults Open
View article: Author response: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults
Author response: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults Open
View article: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults
Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults Open
Childhood adversity is a strong predictor for developing psychopathological conditions. Exposure to threat-related childhood adversity has been suggested to be specifically linked to altered emotional learning as well as changes in neural …
View article: Epigenome-Wide DNA Methylation in Unipolar Depression: Predictive Biomarker of Antidepressant Treatment Response?
Epigenome-Wide DNA Methylation in Unipolar Depression: Predictive Biomarker of Antidepressant Treatment Response? Open
Background Despite the well-documented efficacy of antidepressant agents for the treatment of major depressive disorder (MDD), initial treatment nonresponse rates are high. Recent years have seen an increase in research into predictive bio…
View article: How to Measure Fear Generalization? Reliability and Validity of Commonly Used Indices
How to Measure Fear Generalization? Reliability and Validity of Commonly Used Indices Open
The ability to adaptively transfer acquired fear to novel situations is fundamental for survival in ever-changing environments and may contribute to the emergence and persistence of anxiety disorders. Consequently, research has focused on …
View article: Mental health improvement after the COVID-19 pandemic in individuals with psychological distress
Mental health improvement after the COVID-19 pandemic in individuals with psychological distress Open
The COVID-19 pandemic and associated countermeasures had an immensely disruptive impact on people’s lives. Due to the lack of systematic pre-pandemic data, however, it is still unclear how individuals’ psychological health has been affecte…
View article: Obsessive–compulsive symptoms and brain lesions compatible with multiple sclerosis
Obsessive–compulsive symptoms and brain lesions compatible with multiple sclerosis Open
View article: The definition of treatment resistance in anxiety disorders: a Delphi method‐based consensus guideline
The definition of treatment resistance in anxiety disorders: a Delphi method‐based consensus guideline Open
Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials of innovative therapeutic interventions. However, an explicit definition…
View article: Impact of <i>NPSR1</i> gene variation on the neural correlates of phasic and sustained fear in spider phobia—an imaging genetics and independent replication approach
Impact of <i>NPSR1</i> gene variation on the neural correlates of phasic and sustained fear in spider phobia—an imaging genetics and independent replication approach Open
The functional neuropeptide S receptor 1 (NPSR1) gene A/T variant (rs324981) is associated with fear processing. We investigated the impact of NPSR1 genotype on fear processing and on symptom reduction following treatment in individuals wi…
View article: Virtual Reality exposure therapy in the treatment of public speaking anxiety and social anxiety disorder
Virtual Reality exposure therapy in the treatment of public speaking anxiety and social anxiety disorder Open
Virtual Reality (VR) has emerged as a promising tool in the treatment of anxiety disorders, particularly for exposure-based interventions. This literature review summarizes recent research on the efficacy of Virtual Reality Exposure Therap…
View article: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults
Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults Open
Exposure to adverse childhood experiences (ACEs) is a strong predictor for developing behavioral, somatic and psychopathological conditions. Exposure to threat-related early adversity has been suggested to be specifically linked to altered…
View article: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults
Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults Open
Childhood adversity is a strong predictor of developing psychopathological conditions. Multiple theories on the mechanisms underlying this association have been suggested which, however, differ in the operationalization of ‘exposure.’ Alte…
View article: Bad days build better days: mental health improvement after the COVID-19 pandemic in individuals with psychosocial distress
Bad days build better days: mental health improvement after the COVID-19 pandemic in individuals with psychosocial distress Open
The COVID-19 pandemic and associated countermeasures had an immensely disruptive impact on people’s lives. Due to the lack of systematic pre-pandemic data, however, it is still unclear how individuals’ psychosocial health has been affected…
View article: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults
Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults Open
Childhood adversity is a strong predictor of developing psychopathological conditions. Multiple theories on the mechanisms underlying this association have been suggested which, however, differ in the operationalization of ‘exposure’. Alte…
View article: Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults
Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults Open
Exposure to adverse childhood experiences (ACEs) is a strong predictor for developing behavioral, somatic and psychopathological conditions. Exposure to threat-related early adversity has been suggested to be specifically linked to altered…
View article: Autoantibodies in patients with obsessive-compulsive disorder: a systematic review
Autoantibodies in patients with obsessive-compulsive disorder: a systematic review Open
View article: Prediction of Changes in Negative Affect During the COVID-19 Pandemic by Experimental Fear Conditioning and Generalization Measures
Prediction of Changes in Negative Affect During the COVID-19 Pandemic by Experimental Fear Conditioning and Generalization Measures Open
Adverse experiences interact with individual vulnerability in the etiology of mental disorders, but due to the paucity of longitudinal studies, their precise interplay remains unclear. Here, we investigated how individual differences in th…
View article: The relationship of separation anxiety with the age of onset of panic disorder
The relationship of separation anxiety with the age of onset of panic disorder Open
Aim This study aimed to investigate whether separation anxiety (SA) constitutes a dimension related to age at onset of panic disorder (PD), in homogeneous subgroups of outpatients with PD, based on their age of onset and symptom severity. …