Miriam Abele
YOU?
Author Swipe
View article: Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome Open
Mass-spectrometry-based phosphoproteomics enables the analysis of thousands of protein phosphorylation events across the human proteome. However, there is a lack of scalable, hypothesis-free, and statistically sound approaches for discover…
View article: Mitochondrial damage drives T-cell immunometabolic paralysis after major surgery
Mitochondrial damage drives T-cell immunometabolic paralysis after major surgery Open
Cytotoxic T cell (CTL) dysfunction is a hallmark of immune paralysis after major surgery, increasing susceptibility to severe nosocomial infections and contributing to mortality in critically ill patients. The mechanisms remain poorly unde…
View article: Privacy-preserving multicenter differential protein abundance analysis with FedProt
Privacy-preserving multicenter differential protein abundance analysis with FedProt Open
Quantitative mass spectrometry has revolutionized proteomics by enabling simultaneous quantification of thousands of proteins. Pooling patient-derived data from multiple institutions enhances statistical power but raises serious privacy co…
View article: Privacy-preserving multicenter differential protein abundance analysis with FedProt
Privacy-preserving multicenter differential protein abundance analysis with FedProt Open
Quantitative mass spectrometry has revolutionized proteomics by enabling simultaneous quantification of thousands of proteins. Pooling patient-derived data from multiple institutions enhances statistical power but raises serious privacy co…
View article: Awakening of the RuMP cycle for partial methylotrophy in the thermophile Parageobacillus thermoglucosidasius
Awakening of the RuMP cycle for partial methylotrophy in the thermophile Parageobacillus thermoglucosidasius Open
Given sustainability and scalability concerns of using sugar feedstocks for microbial bioproduction of bulk chemicals, widening the feedstock range for microbial cell factories is of high interest. Methanol is a one-carbon alcohol that sta…
View article: Proteomic Diversity in Bacteria: Insights and Implications for Bacterial Identification
Proteomic Diversity in Bacteria: Insights and Implications for Bacterial Identification Open
Mass spectrometry-based proteomics has revolutionized bacterial identification and elucidated many molecular mechanisms underlying bacterial growth, community formation, and drug resistance. However, most research has been focused on a few…
View article: Awakening of the RuMP cycle for partial methylotrophy in the thermophile <i>Parageobacillus thermoglucosidasius</i>
Awakening of the RuMP cycle for partial methylotrophy in the thermophile <i>Parageobacillus thermoglucosidasius</i> Open
Given sustainability and scalability concerns of using sugar feedstocks for microbial bioproduction of bulk chemicals, widening the feedstock range for microbial cell factories is of high interest. Methanol is a one-carbon alcohol that sta…
View article: Novel amylase genes enable utilisation of resistant starch by bifidobacteria relevant to early-life microbiome development
Novel amylase genes enable utilisation of resistant starch by bifidobacteria relevant to early-life microbiome development Open
Bifidobacterium species and strains are key members of the gut microbiota, appearing soon after birth and persisting into adulthood. Resistant starch is an important dietary substrate for adult-associated bifidobacteria, where its fermenta…
View article: CemR atypical response regulator impacts energy conversion in <i>Campylobacteria</i>
CemR atypical response regulator impacts energy conversion in <i>Campylobacteria</i> Open
Campylobacter jejuni and Arcobacter butzleri are microaerobic food-borne human gastrointestinal pathogens that mainly cause diarrheal disease. These related species of the Campylobacteria class face variable atmospheric environments during…
View article: Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics Open
Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T cell lymphoma (CTCL), peripheral T cell lymphoma (PTCL), and multiple myeloma, but many aspects of their cellular mechanism of action (MoA) and substantial toxicity …
View article: Overexpression of the plastidial pseudo‐protease <scp>AtFtsHi3</scp> enhances drought tolerance while sustaining plant growth
Overexpression of the plastidial pseudo‐protease <span>AtFtsHi3</span> enhances drought tolerance while sustaining plant growth Open
With climate change, droughts are expected to be more frequent and severe, severely impacting plant biomass and quality. Here, we show that overexpressing the Arabidopsis gene AtFtsHi3 ( FtsHi3OE) enhances drought‐tolerant phenotypes witho…
View article: CemR atypical response regulator impacts energy conversion in<i>Campylobacteria</i>
CemR atypical response regulator impacts energy conversion in<i>Campylobacteria</i> Open
Campylobacter jejuni and Arcobacter butzleri are microaerobic food-borne human gastrointestinal pathogens that mainly cause diarrheal disease. These related species of the Campylobacteria class face variable atmospheric environments during…
View article: Abstract 1422 Merits of deep and fast proteomics for bacterial proteome profiling
Abstract 1422 Merits of deep and fast proteomics for bacterial proteome profiling Open
Bottom-up proteomics in synergy with big data science has significantly advanced microbiological research. Comprehensive proteome profiling is pivotal in advancing our knowledge of bacteria and their interactions with the environment, othe…
View article: Regulation of adaptive growth decisions via phosphorylation of the TRAPPII complex in <i>Arabidopsis</i>
Regulation of adaptive growth decisions via phosphorylation of the TRAPPII complex in <i>Arabidopsis</i> Open
Plants often adapt to adverse or stress conditions via differential growth. The trans-Golgi network (TGN) has been implicated in stress responses, but it is not clear in what capacity it mediates adaptive growth decisions. In this study, w…
View article: Unified Workflow for the Rapid and In-Depth Characterization of Bacterial Proteomes
Unified Workflow for the Rapid and In-Depth Characterization of Bacterial Proteomes Open
View article: Regulation of adaptive growth decisions via phosphorylation of the TRAPPII complex in Arabidopsis
Regulation of adaptive growth decisions via phosphorylation of the TRAPPII complex in Arabidopsis Open
Plants often adapt to adverse or stress conditions via differential growth. The trans-Golgi Network (TGN) has been implicated in stress responses, but it is not clear in what capacity it mediates adaptive growth decisions. In this study, w…
View article: Enzyme expression kinetics by Escherichia coli during transition from rich to minimal media depends on proteome reserves
Enzyme expression kinetics by Escherichia coli during transition from rich to minimal media depends on proteome reserves Open
View article: Merits of Diazirine Photo-Immobilization for Target Profiling of Natural Products and Cofactors
Merits of Diazirine Photo-Immobilization for Target Profiling of Natural Products and Cofactors Open
Finding the targets of natural products is of key importance in both chemical biology and drug discovery, and deconvolution of cofactor interactomes contributes to the functional annotation of the proteome. Identifying the proteins that un…
View article: Overexpression of the plastidal pseudo-protease<i>AtFtsHi3</i>confers drought tolerance without penalizing growth
Overexpression of the plastidal pseudo-protease<i>AtFtsHi3</i>confers drought tolerance without penalizing growth Open
Drought is one of the most severe environmental stresses affecting plant biomass production and quality, however, the molecular mechanisms of drought response in plants remain unclear. Here, we demonstrate that overexpression of the Arabid…
View article: Impact of Modified Atmospheres on Growth and Metabolism of Meat-Spoilage Relevant Photobacterium spp. as Predicted by Comparative Proteomics
Impact of Modified Atmospheres on Growth and Metabolism of Meat-Spoilage Relevant Photobacterium spp. as Predicted by Comparative Proteomics Open
Modified atmosphere packaging (MAP) is a common strategy to selectively prevent the growth of certain species of meat spoiling bacteria. This study aimed to determine the impact of high oxygen MAP (70% O 2 , 30% CO 2 , red and white meats)…
View article: Spotlight on alternative frame coding: Two long overlapping genes in Pseudomonas aeruginosa are translated and under purifying selection
Spotlight on alternative frame coding: Two long overlapping genes in Pseudomonas aeruginosa are translated and under purifying selection Open
View article: Bap-Independent Biofilm Formation in Staphylococcus xylosus
Bap-Independent Biofilm Formation in Staphylococcus xylosus Open
The biofilm associated protein (Bap) is recognised as the essential component for biofilm formation in Staphylococcus aureus V329 and has been predicted as important for other species as well. Although Bap orthologs are also present in mos…
View article: Comparative Proteomics Reveals the Anaerobic Lifestyle of Meat-Spoiling Pseudomonas Species
Comparative Proteomics Reveals the Anaerobic Lifestyle of Meat-Spoiling Pseudomonas Species Open
The ability of certain Pseudomonas ( P. ) species to grow or persist in anoxic habitats by either denitrification, acetate fermentation, or arginine fermentation has been described in several studies as a special property. Previously, we h…
View article: Shadow ORFs illuminated: long overlapping genes in<i>Pseudomonas aeruginosa</i>are translated and under purifying selection
Shadow ORFs illuminated: long overlapping genes in<i>Pseudomonas aeruginosa</i>are translated and under purifying selection Open
The existence of overlapping genes (OLGs) with significant coding overlaps revolutionises our understanding of genomic complexity. We report two exceptionally long (957 nt and 1536 nt), evolutionarily novel, translated antisense open readi…
View article: Shadow Orfs Illuminated: Long Overlapping Genes in Pseudomonas Aeruginosa are Translated and Under Purifying Selection
Shadow Orfs Illuminated: Long Overlapping Genes in Pseudomonas Aeruginosa are Translated and Under Purifying Selection Open
View article: Personalized Production, Non-Genomic Engineering, and Time-Resolved Proteomics of Therapeutic Phages for Biohazardous and Multidrug-Resistant Bacteria
Personalized Production, Non-Genomic Engineering, and Time-Resolved Proteomics of Therapeutic Phages for Biohazardous and Multidrug-Resistant Bacteria Open
View article: Interactions between Transport Protein Particle (TRAPP) complexes and Rab <scp>GTP</scp>ases in Arabidopsis
Interactions between Transport Protein Particle (TRAPP) complexes and Rab <span>GTP</span>ases in Arabidopsis Open
Summary Transport Protein Particle II ( TRAPPII ) is essential for exocytosis, endocytosis, protein sorting and cytokinesis. In spite of a considerable understanding of its biological role, little information is known about Arabidopsis TRA…