Miriam C. Klein-Flügge
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View article: Fundamental features of social environments determine rate of social affiliation
Fundamental features of social environments determine rate of social affiliation Open
Humans start new friendships and social connections throughout their lives and such relationships foster mental and physical well-being. While friendship initiation may depend on alignment of subtle and complex personal variables, here we …
View article: ITRUSST consensus on biophysical safety for transcranial ultrasound stimulation
ITRUSST consensus on biophysical safety for transcranial ultrasound stimulation Open
View article: Causal necessity of hippocampus for structure-based inference in learning
Causal necessity of hippocampus for structure-based inference in learning Open
When meeting new individuals or encountering known individuals in new circumstances, we intuitively map out their relationships – not merely by direct experience, but by quickly inferring new connections based on prior relational knowledge…
View article: Distinct roles of hippocampus and neocortex in symbolic compositional generalization
Distinct roles of hippocampus and neocortex in symbolic compositional generalization Open
Humans can combine symbols to generate new meanings. Here, we studied the regional neural mechanisms that might make this possible. We asked participants to combine two discrete, symbolic features (a shape and a colour) to make a novel spa…
View article: Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network-level activity
Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network-level activity Open
The amygdala is a core region changed in depression, a disorder characterized by compromised emotion, motivation and learning processes. However, lesion studies in humans examining amygdala function have largely focused on its role in proc…
View article: Causal necessity of human hippocampus for structure-based inference in learning
Causal necessity of human hippocampus for structure-based inference in learning Open
When meeting new individuals or encountering known individuals in new circumstances, we intuitively map out their relationships – not merely by direct experience, but by quickly inferring new connections based on prior relational knowledge…
View article: Association of Diet and Waist-to-Hip Ratio With Brain Connectivity and Memory in Aging
Association of Diet and Waist-to-Hip Ratio With Brain Connectivity and Memory in Aging Open
Importance Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive hea…
View article: Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment
Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment Open
Mental disorders pose a significant global burden and constitute a major cause of disability worldwide. Despite strides in treatment, a substantial number of patients do not respond adequately, underscoring the urgency for innovative appro…
View article: Friend Request Accepted: Fundamental Features of Social Environments Determine Rate of Social Affiliation
Friend Request Accepted: Fundamental Features of Social Environments Determine Rate of Social Affiliation Open
Humans start new friendships and social connections throughout their lives and such relationships foster mental and physical well-being. While friendship initiation may depend on alignment of subtle and complex personal variables, here we …
View article: A distributed subcortical circuit linked to instrumental information-seeking about threat
A distributed subcortical circuit linked to instrumental information-seeking about threat Open
Daily life for humans and other animals requires switching between periods of threat- and reward-oriented behavior. We investigated neural activity associated with spontaneous switching, in a naturalistic task, between foraging for rewards…
View article: Deep Transcranial Ultrasonic Brain Stimulation During Decision-Making in Changing Social-Emotional Environments
Deep Transcranial Ultrasonic Brain Stimulation During Decision-Making in Changing Social-Emotional Environments Open
View article: Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans
Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans Open
View article: The association of longitudinal diet and waist-to-hip ratio from midlife to old age with hippocampus connectivity and memory in old age: a cohort study
The association of longitudinal diet and waist-to-hip ratio from midlife to old age with hippocampus connectivity and memory in old age: a cohort study Open
Epidemiological studies suggest lifestyle factors may reduce the risk of dementia. However, few studies have examined the association of diet and waist-to-hip ratio with hippocampus connectivity. In the Whitehall II Imaging Sub-study, we e…
View article: The importance of acoustic output measurement and monitoring for the replicability of transcranial ultrasonic stimulation studies
The importance of acoustic output measurement and monitoring for the replicability of transcranial ultrasonic stimulation studies Open
We are writing about what we believe are important considerations for ensuring high standards and replicability of experiments using transcranial ultrasonic stimulation (TUS). TUS is a technique in its infancy, yet its potential is widely …
View article: ITRUSST Consensus on Biophysical Safety for Transcranial Ultrasound Stimulation
ITRUSST Consensus on Biophysical Safety for Transcranial Ultrasound Stimulation Open
Transcranial ultrasound stimulation (TUS) is an emerging technology for non-invasive brain stimulation. The International Transcranial Ultrasonic Stimulation Safety and Standards consortium (ITRUSST) has established consensus on considerat…
View article: Action initiation and punishment learning differ from childhood to adolescence while reward learning remains stable
Action initiation and punishment learning differ from childhood to adolescence while reward learning remains stable Open
View article: Table of Contents
Table of Contents Open
View article: Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans
Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans Open
View article: Generalization of Covariance Structure in Human and Neural Network
Generalization of Covariance Structure in Human and Neural Network Open
View article: Three-layer model with absorption for conservative estimation of the maximum acoustic transmission coefficient through the human skull for transcranial ultrasound stimulation
Three-layer model with absorption for conservative estimation of the maximum acoustic transmission coefficient through the human skull for transcranial ultrasound stimulation Open
View article: Relationship between nuclei-specific amygdala connectivity and mental health dimensions in humans
Relationship between nuclei-specific amygdala connectivity and mental health dimensions in humans Open
View article: Action initiation and punishment learning differ from childhood to adolescence while reward learning remains stable
Action initiation and punishment learning differ from childhood to adolescence while reward learning remains stable Open
Theoretical and empirical accounts suggest that adolescence is associated with heightened reward learning and impulsivity. Experimental tasks and computational models that can dissociate reward learning from the tendency to initiate action…
View article: Increasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain
Increasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain Open
Significance Oscillatory activity is prominent in the brain, and one hypothesis is that it is, in part, due to the nature of coupling or interaction patterns between brain areas. We tested this hypothesis by manipulating the strength of co…
View article: Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice
Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice Open
View article: Structural and resting state functional connectivity beyond the cortex
Structural and resting state functional connectivity beyond the cortex Open
View article: Causal manipulation of self-other mergence in the dorsomedial prefrontal cortex
Causal manipulation of self-other mergence in the dorsomedial prefrontal cortex Open
To navigate social environments, people must simultaneously hold representations about their own and others' abilities. During self-other mergence, people estimate others' abilities not only on the basis of the others' past performance, bu…
View article: Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice
Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice Open
Choices rely on a transformation of sensory inputs into motor responses. Using invasive single neuron recordings, the evolution of a choice process has been tracked by projecting population neural responses into state spaces. Here, we deve…
View article: Author response: Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice
Author response: Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Choices rely on a transformation of sensor…
View article: Activation and disruption of a neural mechanism for novel choice in monkeys
Activation and disruption of a neural mechanism for novel choice in monkeys Open
View article: Data and code for "Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice"
Data and code for "Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice" Open
Source data and main experimental code for manuscript "Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice" published in Nature Communications in 2021