Miriam Ratliff
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View article: Employing nanopore sequencing on FFPE-derived DNA for CNS tumor diagnostics
Employing nanopore sequencing on FFPE-derived DNA for CNS tumor diagnostics Open
View article: TMIC-86. Meningioma brain-invasion is linked to inflammatory induced tumor-neuronal connectivity
TMIC-86. Meningioma brain-invasion is linked to inflammatory induced tumor-neuronal connectivity Open
Brain-invasion of meningioma is a hallmark of malignant behavior and linked to higher risk of surgical resection and poor clinical outcome. Here, we hypothesized that meningioma tumor ecosystems with invasive behavior enhance cellular comm…
View article: EPCO-43. A MULTI-MODAL SINGLE-CELL AND SPATIAL TRANSCRIPTOMIC ATLAS REVEALS GENE-PROGRAM AND NEIGHBOURHOOD DRIVERS OF MENINGIOMA MALIGNISATION
EPCO-43. A MULTI-MODAL SINGLE-CELL AND SPATIAL TRANSCRIPTOMIC ATLAS REVEALS GENE-PROGRAM AND NEIGHBOURHOOD DRIVERS OF MENINGIOMA MALIGNISATION Open
BACKGROUND Meningiomas range from indolent to highly aggressive, yet current grading captures only part of its biological diversity. METHODS We built an integrated atlas by profiling 302 133 nuclei from 47 meningiomas with scnuc-RNA-seq an…
View article: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression
Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression Open
Glioblastomas are incurable primary brain tumors that depend on neural-like cellular processes, tumor microtubes (TMs), to invade the brain. TMs also interconnect single tumor cells to a communicating multicellular network that resists cur…
View article: Spatial Transcriptomics Characterisation of Radionecrotic Changes in Glioblastoma Patients
Spatial Transcriptomics Characterisation of Radionecrotic Changes in Glioblastoma Patients Open
Background: IDH-wildtype Glioblastoma (GB) is the most prevalent primary CNS tumour in adults. The standard treatment involves radiotherapy, which can cause radionecrotic changes. Progressive GB and radionecrotic changes can be challenging…
View article: P14.25.B DECODING MORPHO-MOLECULAR DIVERSITY IN GLIOSARCOMA AND INSIGHTS INTO RESISTANCE USING SPATIAL TRANSCRIPTOMICS
P14.25.B DECODING MORPHO-MOLECULAR DIVERSITY IN GLIOSARCOMA AND INSIGHTS INTO RESISTANCE USING SPATIAL TRANSCRIPTOMICS Open
BACKGROUND Gliosarcoma, a rare and aggressive variant of IDH-wildtype glioblastoma, is characterized by striking intra-tumoral heterogeneity with alternating glial and mesenchymal differentiation. The mesenchymal component is often enriche…
View article: Music During Awake Brain Tumor Resection: A Case Series
Music During Awake Brain Tumor Resection: A Case Series Open
View article: Distinct molecular profile and outcome of oligodendroglioma, <i>IDH</i>-mutant, 1p/19q-codeleted, and <i>TERT</i>p-wildtype: A grade 1 oligodendroglioma of young patients?
Distinct molecular profile and outcome of oligodendroglioma, <i>IDH</i>-mutant, 1p/19q-codeleted, and <i>TERT</i>p-wildtype: A grade 1 oligodendroglioma of young patients? Open
Background Oligodendrogliomas, characterized by isocitrate dehydrogenase (IDH) mutations and 1p/19q codeletion, often exhibit telomerase reverse transcriptase promoter (TERTp) mutations, which have been linked to telomere maintenance (TM) …
View article: Innovative Therapeutic Strategies Targeting the Network Architecture of Glioblastoma
Innovative Therapeutic Strategies Targeting the Network Architecture of Glioblastoma Open
Recent discoveries concerning the network architecture of glioblastoma, including tumor microtubules and neuron–glioma synapses, have underscored critical pathways that sustain tumor growth, enhance resistance, and integrate glioblastoma w…
View article: Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy
Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy Open
Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications for predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individual…
View article: Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen
Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen Open
View article: Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics Open
View article: Molecular, histologic, and clinical characterization of methylation class pleomorphic xanthoastrocytoma: An analysis of 469 tumors
Molecular, histologic, and clinical characterization of methylation class pleomorphic xanthoastrocytoma: An analysis of 469 tumors Open
Background Methylation class pleomorphic xanthoastrocytoma (mcPXA) comprises tumors with the DNA methylation signature of classical PXA but with a wider histologic spectrum, including overlap with glioblastoma (GBM). Methods To clarify the…
View article: Transgenic T cell therapy targeting the glioblastoma stem cell antigen PTPRZ1 with a vaccine-induced, patient-derived T cell receptor
Transgenic T cell therapy targeting the glioblastoma stem cell antigen PTPRZ1 with a vaccine-induced, patient-derived T cell receptor Open
Response to CAR-T cell therapy in glioblastoma (GB) patients is limited, particularly because of the paucity of cell surface immunotherapeutic targets or low antigen sensitivity. Moreover, tonic CAR signaling leads to T cell dysfunction ev…
View article: Disrupting glioblastoma networks with tumor treating fields (TTFields) in in vitro models
Disrupting glioblastoma networks with tumor treating fields (TTFields) in in vitro models Open
Purpose This study investigates the biological effect of Tumor Treating Fields (TTFields) on key drivers of glioblastoma’s malignancy—tumor microtube (TM) formation—and on the function and overall integrity of the tumor cell network. Metho…
View article: MDB-71. IDENTIFICATION AND DESCRIPTION OF A NOVEL TYPE OF MEDULLOBLASTOMA
MDB-71. IDENTIFICATION AND DESCRIPTION OF A NOVEL TYPE OF MEDULLOBLASTOMA Open
BACKGROUND Medulloblastoma (MB) is one of the most frequent high-grade brain tumor types of childhood and adolescence. Based on biology, histology, and its clinical course, MB is a heterogeneous disease with four different molecular types …
View article: Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy
Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy Open
The identification of patient-derived, tumor-reactive T cell receptors (TCRs) as a basis for personalized transgenic T cell therapies remains a time- and cost-intensive endeavor. Current approaches to identify tumor-reactive TCRs analyze t…
View article: A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1 Open
View article: PerSurge (NOA-30) phase II trial of perampanel treatment around surgery in patients with progressive glioblastoma
PerSurge (NOA-30) phase II trial of perampanel treatment around surgery in patients with progressive glioblastoma Open
Background Glioblastoma is the most frequent and a particularly malignant primary brain tumor with no efficacy-proven standard therapy for recurrence. It has recently been discovered that excitatory synapses of the AMPA-receptor subtype fo…
View article: Fluorescein-stained confocal laser endomicroscopy versus conventional frozen section for intraoperative histopathological assessment of intracranial tumors
Fluorescein-stained confocal laser endomicroscopy versus conventional frozen section for intraoperative histopathological assessment of intracranial tumors Open
Background The aim of this clinical trial was to compare Fluorescein-stained intraoperative confocal laser endomicroscopy (CLE) of intracranial lesions and evaluation by a neuropathologist with routine intraoperative frozen section (FS) as…
View article: Concurrent gliomas in patients with multiple sclerosis
Concurrent gliomas in patients with multiple sclerosis Open
View article: EPID-20. SEX-SPECIFIC DIFFERENCES IN MENINGIOMA SUBTYPES AND MUTATIONS – A RETROSPECTIVE ANALYSIS
EPID-20. SEX-SPECIFIC DIFFERENCES IN MENINGIOMA SUBTYPES AND MUTATIONS – A RETROSPECTIVE ANALYSIS Open
A variety of intrinsic and extrinsic factors are known to influence and promote the development of cancer. Although the patients’ gender can influence extrinsic factors, biological sex is an important intrinsic factor. Here, it must also b…
View article: Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics
Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics Open
View article: NLGN4X TCR transgenic T cells to treat gliomas
NLGN4X TCR transgenic T cells to treat gliomas Open
Background Neuroligin 4 X-linked (NLGN4X) harbors a human leukocyte antigen (HLA)-A*02-restricted tumor-associated antigen, overexpressed in human gliomas, that was found to induce specific cytotoxic T cell responses following multi-peptid…
View article: P02.07.A IMMUNOLOGICAL AND EPIGENETIC FEATURES OF RADIATION NECROSIS IN GLIOBLASTOMA PATIENTS
P02.07.A IMMUNOLOGICAL AND EPIGENETIC FEATURES OF RADIATION NECROSIS IN GLIOBLASTOMA PATIENTS Open
BACKGROUND Radiation necrosis is a rare but highly relevant complication after radiotherapy in glioblastoma patients. Immunological and epigenetic features of these delayed tissue changes are not yet understood and no reliable biomarker to…
View article: Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression
Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression Open
Background Glioblastomas are characterized by aggressive and infiltrative growth, and by striking heterogeneity. The aim of this study was to investigate whether tumor cell proliferation and invasion are interrelated, or rather distinct fe…
View article: Depression in brain tumor patients—early detection and screening
Depression in brain tumor patients—early detection and screening Open
Background Depres sion is reported in up to 90% of cancer patients but to this date, a standardized screening tool for depression specifically modified for patients diagnosed with brain tumors is lacking. Thus, this study aims to develop a…
View article: Supplementary Figure 7 from Identification and Characterization of Cancer Cells That Initiate Metastases to the Brain and Other Organs
Supplementary Figure 7 from Identification and Characterization of Cancer Cells That Initiate Metastases to the Brain and Other Organs Open
Supplementary Figure 7 shows correlation of NDRG1 expression with tumor growth in mouse and human samples.
View article: Supplementary Figure 5 from Identification and Characterization of Cancer Cells That Initiate Metastases to the Brain and Other Organs
Supplementary Figure 5 from Identification and Characterization of Cancer Cells That Initiate Metastases to the Brain and Other Organs Open
Supplementary Figure 5 shows cell cycle analysis.
View article: Supplementary Figure 4 from Identification and Characterization of Cancer Cells That Initiate Metastases to the Brain and Other Organs
Supplementary Figure 4 from Identification and Characterization of Cancer Cells That Initiate Metastases to the Brain and Other Organs Open
Supplementary Figure 4 shows IVIS results.