Miriam Schiffer
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View article: Efficient <i>in vivo</i> targeting of the myocardial scar using Moloney murine leukaemia virus complexed with nanoparticles
Efficient <i>in vivo</i> targeting of the myocardial scar using Moloney murine leukaemia virus complexed with nanoparticles Open
During myocardial infarction, native myocardium is replaced by a fibrous scar, impairing cardiac pump function and leading to potentially life‐threatening ventricular tachycardias. Gene therapy‐based targeting of the cardiac scar is essent…
View article: Nanoparticle-assisted targeting of heart lesions with cardiac myofibroblasts: Combined gene and cell therapy
Nanoparticle-assisted targeting of heart lesions with cardiac myofibroblasts: Combined gene and cell therapy Open
Rationale: The cardiac scar is an area rich in collagen. It is populated by myofibroblasts and lacks Connexin 43 expressing cardiomyocytes. Myocardial infarctions have so far proven little amenable to gene- and cell-based therapeuti…
View article: Electrically Conductive Collagen‐PEDOT:PSS Hydrogel Prevents Post‐Infarct Cardiac Arrhythmia and Supports hiPSC‐Cardiomyocyte Function
Electrically Conductive Collagen‐PEDOT:PSS Hydrogel Prevents Post‐Infarct Cardiac Arrhythmia and Supports hiPSC‐Cardiomyocyte Function Open
Myocardial infarction (MI) causes cell death, disrupts electrical activity, triggers arrhythmia, and results in heart failure, whereby 50–60% of MI‐associated deaths manifest as sudden cardiac deaths (SCD). The most effective therapy for S…
View article: Nanoparticle Assisted Targeting of Heart Lesions with Cardiac Myofibroblasts: Combined Gene and Cell Therapy
Nanoparticle Assisted Targeting of Heart Lesions with Cardiac Myofibroblasts: Combined Gene and Cell Therapy Open
View article: Combined use of magnetic microbeads for endothelial cell isolation and enhanced cell engraftment in myocardial repair
Combined use of magnetic microbeads for endothelial cell isolation and enhanced cell engraftment in myocardial repair Open
Background: The regenerative potential of the heart after injury is limited. Therefore, cell replacement strategies have been developed. However, the engraftment of transplanted cells in the myocardium is very inefficient. In additi…
View article: Generation and Characterization of an Inducible Cx43 Overexpression System in Mouse Embryonic Stem Cells
Generation and Characterization of an Inducible Cx43 Overexpression System in Mouse Embryonic Stem Cells Open
Connexins (Cx) are a large family of membrane proteins that can form intercellular connections, so-called gap junctions between adjacent cells. Cx43 is widely expressed in mammals and has a variety of different functions, such as the propa…
View article: Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling
Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling Open
Ventricular tachycardia (VT) is the most common and potentially lethal complication following myocardial infarction (MI). Biological correction of the conduction inhomogeneity that underlies re-entry could be a major advance in infarction …
View article: Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes
Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes Open
Casp8-dependent migration of enterocytes is likely involved in intestinal physiology and inflammation-related pathophysiology.