Mirjam Baanstra
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View article: Optimization of the Production Process of Clinical-Grade Human Salivary Gland Organoid-Derived Cell Therapy for the Treatment of Radiation-Induced Xerostomia in Head and Neck Cancer
Optimization of the Production Process of Clinical-Grade Human Salivary Gland Organoid-Derived Cell Therapy for the Treatment of Radiation-Induced Xerostomia in Head and Neck Cancer Open
Head and neck cancer is a common cancer worldwide. Radiotherapy has an essential role in the treatment of head and neck cancers. After irradiation, early effects of reduced saliva flow and hampered water secretion are seen, along with cell…
View article: Transposable Element Derepression-mediated IFN-I Signaling Enhances Stem/Progenitor Cell Activity After Irradiation
Transposable Element Derepression-mediated IFN-I Signaling Enhances Stem/Progenitor Cell Activity After Irradiation Open
Radiotherapy is a mainstay in cancer treatment, aiming to maximize DNA damage in tumors while minimizing harm to surrounding healthy tissues. However, the collateral damage to normal tissues, especially stem/progenitor cells essential for …
View article: Role of immediate early genes in the development of salivary gland organoids in polyisocyanopeptide hydrogels
Role of immediate early genes in the development of salivary gland organoids in polyisocyanopeptide hydrogels Open
Human salivary gland organoids have opened tremendous possibilities for regenerative medicine in patients undergoing radiotherapy for the treatment of head and neck cancer. However, their clinical translation is greatly limited by the curr…
View article: Organoids as a model to study intestinal and liver dysfunction in severe malnutrition
Organoids as a model to study intestinal and liver dysfunction in severe malnutrition Open
Hospitalized children with severe malnutrition face high mortality rates and often suffer from hepatic and intestinal dysfunction, with negative impacts on their survival. New treatments cannot be developed without understanding the underl…
View article: The Hippo signaling pathway effector YAP promotes salivary gland regeneration after injury
The Hippo signaling pathway effector YAP promotes salivary gland regeneration after injury Open
YAP stimulates the proliferation and regenerative potential of ductal cells after salivary gland injury.
View article: Autophagy induction during stem cell activation plays a key role in salivary gland self-renewal
Autophagy induction during stem cell activation plays a key role in salivary gland self-renewal Open
Relatively quiescent tissues like salivary glands (SGs) respond to stimuli such as injury to expand, replace and regenerate. Resident stem/progenitor cells are key in this process because, upon activation, they possess the ability to self-…
View article: Generation and Differentiation of Adult Tissue-Derived Human Thyroid Organoids
Generation and Differentiation of Adult Tissue-Derived Human Thyroid Organoids Open
View article: Mouse parotid salivary gland organoids for the in vitro study of stem cell radiation response
Mouse parotid salivary gland organoids for the in vitro study of stem cell radiation response Open
Objective Hyposalivation‐related xerostomia is an irreversible, untreatable, and frequent condition after radiotherapy for head and neck cancer. Stem cell therapy is an attractive option of treatment, but demands knowledge of stem cell fun…
View article: Hedgehog Pathway as a Potential Intervention Target in Esophageal Cancer
Hedgehog Pathway as a Potential Intervention Target in Esophageal Cancer Open
Esophageal cancer (EC) is an aggressive disease with a poor prognosis. Treatment resistance is a major challenge in successful anti-cancer therapy. Pathological complete response after neoadjuvant chemoradiation (nCRT) is low, thus requiri…
View article: Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction
Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction Open
Purpose: Radiotherapy for head and neck cancer may result in serious side effects, such as hyposalivation, impairing the patient's quality of life. Modern radiotherapy techniques attempt to reduce the dose to salivary glands, which, howeve…
View article: Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer
Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer Open
Avoiding irradiation of the region of the parotid gland containing stem cells reduces the risk of xerostomia (dry mouth).