Mirko E. Minniti
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View article: Application of Mathematical Models for Blood Flow in Aorta and Right Coronary Artery
Application of Mathematical Models for Blood Flow in Aorta and Right Coronary Artery Open
Cardiovascular diseases represent one of the leading causes of mortality worldwide, underscoring the need for accurate simulations of blood flow to improve diagnosis and treatment. This study examines blood flow dynamics in two different v…
View article: Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior
Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior Open
The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral signals on the central clock remains poorly characterized. To explore whether periph…
View article: Mice with humanized livers reveal the involvement of hepatocyte circadian clocks in rhythmic behavior and physiology
Mice with humanized livers reveal the involvement of hepatocyte circadian clocks in rhythmic behavior and physiology Open
The circadian clock is an evolutionarily acquired gene network that synchronizes physiological processes to adapt homeostasis to the succession of day and night. While most mammalian cells have a circadian clock, their synchronization at t…
View article: Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice
Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice Open
Background\nSterol O-acyltransferase 2 (Soat2) encodes acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), which synthesizes cholesteryl esters in hepatocytes and enterocytes fated either to storage or to secretion into nascent triglyce…
View article: Fighting cardiometabolic disease : validation of new experimental models and therapeutic targets
Fighting cardiometabolic disease : validation of new experimental models and therapeutic targets Open
The prevalence of cardiometabolic diseases (CMD) such as atherosclerotic cardiovascular diseases, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), has grown dramatically during the last decades. Hence, massive researc…
View article: Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans
Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans Open
Background and Aims Genetically modified mice have been used extensively to study human disease. However, the data gained are not always translatable to humans because of major species differences. Liver‐humanized mice (LHM) are considered…
View article: Ezetimibe in Combination With Simvastatin Reduces Remnant Cholesterol Without Affecting Biliary Lipid Concentrations in Gallstone Patients
Ezetimibe in Combination With Simvastatin Reduces Remnant Cholesterol Without Affecting Biliary Lipid Concentrations in Gallstone Patients Open
Background In randomized trials (SHARP [Study of Heart and Renal Protection], IMPROVE ‐IT [Improved Reduction of Outcomes: Vytorin Efficacy International Trial]), combination of statin and ezetimibe resulted in additional reduction of card…