Miroslav Zavoral
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View article: Endoscopic luminal impedance planimetry of the lower oesophageal sphincter and pylorus in experimental pigs: a pilot study
Endoscopic luminal impedance planimetry of the lower oesophageal sphincter and pylorus in experimental pigs: a pilot study Open
Endoscopic functional luminal planimetry in experimental pigs is feasible, both for the lower oesophageal sphincter and the pylorus. This is an important starting point for future experimental endoscopic trials and pharmacology studies.
View article: The Effect of Tacrine on Functional Response of the Lower Oesophageal Sphincter Assessed by Endoscopic Luminal Impedance Planimetry in Experimental Pigs
The Effect of Tacrine on Functional Response of the Lower Oesophageal Sphincter Assessed by Endoscopic Luminal Impedance Planimetry in Experimental Pigs Open
Background/Objectives: Tacrine is a centrally active non-competitive reversible acetylcholinesterase inhibitor. It also exerts antagonising activity against N-methyl-D-aspartate receptors. Tacrine was approved for the treatment of Alzheime…
View article: Prognostic Role of Specific KRAS Mutations Detected in Aspiration and Liquid Biopsies from Patients with Pancreatic Cancer
Prognostic Role of Specific KRAS Mutations Detected in Aspiration and Liquid Biopsies from Patients with Pancreatic Cancer Open
Background/Objectives: Although the overall survival prognosis of patients in advanced stages of pancreatic ductal adenocarcinoma (PDAC) is poor, typically ranging from days to months from diagnosis, there are rare cases of patients remain…
View article: Impact of narrow-band imaging in prediction of histology of colorectal neoplasia: a prospective study
Impact of narrow-band imaging in prediction of histology of colorectal neoplasia: a prospective study Open
Aims: We assessed the diagnostic performance of the Narrow-Band Imaging (NBI) International Colorectal Endoscopic Classification (NICE) and the Japan NBI Expert Team classification (JNET) in predicting histological outcomes of colorectal l…
View article: Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus
Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus Open
Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis, with near-identical incidence and mortality. According to the World Health Organization Globocan Database, the estimated number of new cases worl…
View article: Coverage by examinations associated with early detection of colorectal neoplasia in the Czech Republic
Coverage by examinations associated with early detection of colorectal neoplasia in the Czech Republic Open
Background Coverage by examinations is a crucial indicator of the future impact on the burden of colorectal cancer (CRC). The study aimed to evaluate coverage by examinations associated with CRC screening and early cancer detection of CRC …
View article: Wireless Monitoring of Gastrointestinal Transit Time, Intra-luminal pH, Pressure and Temperature in Experimental Pigs: A Pilot Study
Wireless Monitoring of Gastrointestinal Transit Time, Intra-luminal pH, Pressure and Temperature in Experimental Pigs: A Pilot Study Open
Background: There is no single gold standard for investigation of gastrointestinal motility function. Wireless motility monitoring involves a novel concept which provides a complex information on gastrointestinal function (gastrointestinal…
View article: Gastrointestinal toxicity of systemic oncology immunotherapy
Gastrointestinal toxicity of systemic oncology immunotherapy Open
Awareness of possible complications of systemic anti-cancer immunotherapy is crucial for patients safety. It is mandatory to consider immune-related adverse events, complicating infections, bile acids malabsorption and small intestinal bac…
View article: Complete coverage by examinations: relationship to colorectal cancer burden and the COVID-19
Complete coverage by examinations: relationship to colorectal cancer burden and the COVID-19 Open
Background Colorectal cancer (CRC) is among the most common cancers and cancer causes of death worldwide. CRC screening and early detection is essential to reduce CRC incidence and mortality. CRC screening has been initiated in the Czech R…
View article: Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma
Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma Open
(1) Background: this prospective study was focused on detailed analysis of the mutation heterogeneity in colorectal lesions removed during baseline (index) colonoscopy to identify patients at high risk of early occurrence of metachronous a…
View article: Pathophysiological Characteristics Linking Type 2 Diabetes Mellitus and Colorectal Neoplasia
Pathophysiological Characteristics Linking Type 2 Diabetes Mellitus and Colorectal Neoplasia Open
A substantial body of literature has provided evidence that type 2 diabetes mellitus (T2DM) and colorectal neoplasia share several common factors. Both diseases are among the leading causes of death worldwide and have an increasing inciden…
View article: Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study
Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study Open
Background and Aims: Adequate bowel preparation is essential for successful and effective colonoscopy. Several types of cleansing agents are currently available including low-volume solutions. The aim of this study was to compare the effic…
View article: Invitation of non-attenders to colorectal cancer screening: impact on coverage by examination
Invitation of non-attenders to colorectal cancer screening: impact on coverage by examination Open
Issue Colorectal cancer (CRC) has been among the most important cancer causes of death globally. CRC screening and early detection can decrease CRC incidence and mortality through timely removal of colorectal neoplasia or early CRC treatme…
View article: 3D high-resolution anorectal manometry − selected case reports
3D high-resolution anorectal manometry − selected case reports Open
Presented selected case reports are focused on the individual cases of patients suffering from functional anorectal disorders. During the examination algorithm, the emphasis is on 3D high-resolution anorectal manometry, which is a useful d…
View article: Zenker’s diverticulum – effectiveness of endoscopic therapy
Zenker’s diverticulum – effectiveness of endoscopic therapy Open
Zenker’s diverticulum is the most common type of esophageal diverticulum with a prevalence of 0.01 to 0.11 %, usually found in middle-aged and older patients. The prevalent symptoms are dysphagia and regurgitation. Treatment is recommended…
View article: Update and review of diagnosing functional anorectal disorders – standardized protocol for high-resolution anorectal manometry and the London classification
Update and review of diagnosing functional anorectal disorders – standardized protocol for high-resolution anorectal manometry and the London classification Open
Complex anorectal examination including a detailed medical history, physical proctological examination and evaluation of the sensorimotor and structural function of the anorectum is essential for the diagnosis and therapeutic management of…
View article: Accuracy of Colon Capsule Endoscopy for Colorectal Neoplasia Detection in Individuals Referred for a Screening Colonoscopy
Accuracy of Colon Capsule Endoscopy for Colorectal Neoplasia Detection in Individuals Referred for a Screening Colonoscopy Open
Backround . Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim . To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with c…
View article: Radiofrequency Ablation in Patients with Barrett’s Esophagus- related Neoplasia – Long-Term Outcomes in the Czech National Database
Radiofrequency Ablation in Patients with Barrett’s Esophagus- related Neoplasia – Long-Term Outcomes in the Czech National Database Open
Background and Aims: Radiofrequency ablation (RFA) with/without endoscopic resection (ER) is the standard endoscopic treatment modality for Barrett‘s esophagus (BE) related neoplasia (BORN). The main aim of this study was to assess the lon…
View article: P817 Profiles of somatic mutations in tissue of IBD and IBD-associated carcinomas revealed by a targeted next-generation sequencing (NGS) tumour panel confirm notable differences from sporadic colorectal carcinomas
P817 Profiles of somatic mutations in tissue of IBD and IBD-associated carcinomas revealed by a targeted next-generation sequencing (NGS) tumour panel confirm notable differences from sporadic colorectal carcinomas Open
Inflammatory bowel diseases (IBD) present an increased risk of developing colorectal carcinoma. Neutrophil-released chemicals in the immune response to inflammation causes mutagenesis, and its long-term effects may result in the developmen…
View article: Listerial myocarditis as a complication of Listerial meningoencephalitis
Listerial myocarditis as a complication of Listerial meningoencephalitis Open
Uvádíme případ 53letého pacienta, který byl přijat pro akutní ischemickou mozkovou příhodu. Během hospitalizace se u pacienta rozvinula meningoencefalitida a akutní myokarditida s rekurentními epizodami fibrilace komor vyžadujícími opakova…
View article: Troponin levels in patients with stable CAD
Troponin levels in patients with stable CAD Open
Úvod: Srdeční troponiny jsou známy jako specifické markery myokardiálního poškození. Zvýšení jejich sérových koncentrací nemusí být vždy spojeno s akutní myokardiální ischemií. Díky rostoucí senzitivitě diagnostických kitů stoupá počet poz…
View article: Bioabsorbable stents in routine practice. New epoch in interventional cardiology
Bioabsorbable stents in routine practice. New epoch in interventional cardiology Open
Úvod: Implantace vstřebatelných stentů (bioabsorbable vascular scaffolding, BVS) představuje podle dosavadních zkušeností slibnou perspektivu v intervenční kardiologii. Na pracovišti katetrizační jednotky Ústřední vojenské nemocnice implan…