Miryam Adelfio
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View article: Engineered Tissue Models to Decode Host–Microbiota Interactions
Engineered Tissue Models to Decode Host–Microbiota Interactions Open
A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but also contribut…
View article: Sustaining healthy long-term host-microbiome interactions in a physiologically relevant dynamic gingival tissue model
Sustaining healthy long-term host-microbiome interactions in a physiologically relevant dynamic gingival tissue model Open
Host-oral microbiome interactions are known to be critical in maintaining local and systemic health of the human body, although they are difficult to study in both clinical and in vitro applications. Despite efforts, recapitulation of ging…
View article: Three‐Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome
Three‐Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome Open
The oral cavity contains distinct microenvironments that serve as oral barriers, such as the non‐shedding surface of the teeth (e.g., enamel), the epithelial mucosa and gingival tissue (attached gingiva) where microbial communities coexist…
View article: Three-dimensional humanized gingival tissue model to study oral microbiome
Three-dimensional humanized gingival tissue model to study oral microbiome Open
The oral cavity contains different microenvironments, as the non-shedding surface of the teeth and the epithelial mucosa, where oral barriers and microbial communities coexist. The interactions and balances between these two communities ar…
View article: <i>In Vitro</i> Nasal Tissue Model for the Validation of Nasopharyngeal and Midturbinate Swabs for SARS-CoV-2 Testing
<i>In Vitro</i> Nasal Tissue Model for the Validation of Nasopharyngeal and Midturbinate Swabs for SARS-CoV-2 Testing Open
Large-scale population testing is a key tool to mitigate the spread of respiratory pathogens, such as the current COVID-19 pandemic, where swabs are used to collect samples in the upper airways (e.g., nasopharyngeal and midturbinate nasal …
View article: Long-Term <i>In Vitro</i> Culture Systems to Study Human Microbiome
Long-Term <i>In Vitro</i> Culture Systems to Study Human Microbiome Open
Microbial communities are eubiotic ecosystems that interact dynamically and synergistically with the human body. Imbalances in these interactions may cause dysbiosis by enhancing the occurrence of inflammatory conditions, such as periodont…
View article: <i>In Vitro</i>Nasal Tissue Model for the Validation of Nasopharyngeal and Mid-turbinate Swabs for SARS-CoV-2 Testing
<i>In Vitro</i>Nasal Tissue Model for the Validation of Nasopharyngeal and Mid-turbinate Swabs for SARS-CoV-2 Testing Open
Large-scale population testing is a key tool to mitigate the spread of respiratory pathogens, as in the current COVID-19 pandemic, where swabs are used to collect samples in the upper airways (e.g. nasopharyngeal and mid-turbinate nasal ca…
View article: Preclinical and clinical validation of a novel injected molded swab for molecular assay detection of SARS-CoV-2 virus
Preclinical and clinical validation of a novel injected molded swab for molecular assay detection of SARS-CoV-2 virus Open
During the COVID-19 public health emergency, many actions have been undertaken to help ensure that patients and health care providers had timely and continued access to high-quality medical devices to respond effectively. The development a…