Hasan Mirza
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View article: British Association for Sexual Health and HIV National Guideline on the Management of Scabies in adults 2025
British Association for Sexual Health and HIV National Guideline on the Management of Scabies in adults 2025 Open
The British Association for Sexual Health and HIV UK guideline on the management of scabies has been updated in 2025. It provides details on the pathology and clinical features of scabies, with evidence-informed, practical recommendations …
View article: Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor
Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor Open
Poly(ADP-ribose) polymerase inhibitors (PARPi) have revolutionised the treatment of ovarian high grade serous carcinoma (HGSC), especially those with defective homologous recombination. However, the emergence of resistance poses a critical…
View article: Spatial transcriptomic analysis reveals significant differences in tumor microenvironment in HPV-dependent and HPV-independent vulvar squamous cell carcinoma
Spatial transcriptomic analysis reveals significant differences in tumor microenvironment in HPV-dependent and HPV-independent vulvar squamous cell carcinoma Open
This study represents the first application of spatial transcriptomics in VSCC, with significantly more immune cells identified in HPVi SCC than in HPVd SCC. These data will act as a baseline for future studies.
View article: Table S1 Antibodies from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Table S1 Antibodies from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Table of antibodies used in flow cytometry and immunohistochemistry.
View article: Table S2 Genes per cluster from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Table S2 Genes per cluster from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Genes upregulated in each mouse macrophage cluster
View article: Table S3 HMOX1-hi gene expression from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Table S3 HMOX1-hi gene expression from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Up- and down-regulated differentially expressed genes in HMOX1-hi human macrophages
View article: Supplementary Methods from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Supplementary Methods from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Description of supplementary methods
View article: Supplementary Figure legends from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Supplementary Figure legends from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Legends to supplementary figures
View article: Supplementary Figures from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Supplementary Figures from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
8 supplementary figures
View article: Table S2 Genes per cluster from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Table S2 Genes per cluster from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Genes upregulated in each mouse macrophage cluster
View article: Supplementary Figure legends from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Supplementary Figure legends from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Legends to supplementary figures
View article: Data from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Data from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
High-grade serous ovarian carcinoma (HGSC) remains a disease with poor prognosis that is unresponsive to current immune checkpoint inhibitors. Although PI3K pathway alterations, such as PTEN loss, are common in HGSC, attempts to tar…
View article: Supplementary Methods from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Supplementary Methods from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Description of supplementary methods
View article: Supplementary Figures from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Supplementary Figures from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
8 supplementary figures
View article: Table S1 Antibodies from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Table S1 Antibodies from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Table of antibodies used in flow cytometry and immunohistochemistry.
View article: Table S3 HMOX1-hi gene expression from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Table S3 HMOX1-hi gene expression from <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
Up- and down-regulated differentially expressed genes in HMOX1-hi human macrophages
View article: <i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
<i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma Open
High-grade serous ovarian carcinoma (HGSC) remains a disease with poor prognosis that is unresponsive to current immune checkpoint inhibitors. Although PI3K pathway alterations, such as PTEN loss, are common in HGSC, attempts to target thi…
View article: The genomic trajectory of ovarian high‐grade serous carcinoma can be observed in <scp>STIC</scp> lesions
The genomic trajectory of ovarian high‐grade serous carcinoma can be observed in <span>STIC</span> lesions Open
Ovarian high‐grade serous carcinoma (HGSC) originates in the fallopian tube, with secretory cells carrying a TP53 mutation, known as p53 signatures, identified as potential precursors. p53 signatures evolve into serous tubal intraepithelia…
View article: 22P Platinum resistance development in high grade serous ovarian carcinoma: Exploring epigenetic alterations as potential drivers of resistance in ovarian cancer relapse at transcriptomic level
22P Platinum resistance development in high grade serous ovarian carcinoma: Exploring epigenetic alterations as potential drivers of resistance in ovarian cancer relapse at transcriptomic level Open
Considerable efforts have been made to understand the leading causal mechanisms behind the development of platinum resistance in relapsed High Grade Serous ovarian Cancer (HGSC) patients. Accumulating evidence shows that epigenetic alterat…
View article: cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance
cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance Open
Aberrant cMYC activity is a key driver of cancer, involved in several hallmark processes. Alongside the canonical hallmark of proliferation, cMYC represses immune signalling in a cell-intrinsic manner. The histone methyltransferases EZH2 a…
View article: Author Correction: The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma
Author Correction: The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma Open
View article: Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin Open
Supplementary methods and figures
View article: Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin Open
Supplementary methods and figures
View article: Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin Open
Supplementary tables
View article: Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin Open
Supplementary tables
View article: Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin Open
Ovarian carcinosarcoma (OCS) is an aggressive and rare tumor type with limited treatment options. OCS is hypothesized to develop via the combination theory, with a single progenitor resulting in carcinomatous and sarcomatous components, or…
View article: Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin Open
Ovarian carcinosarcoma (OCS) is an aggressive and rare tumor type with limited treatment options. OCS is hypothesized to develop via the combination theory, with a single progenitor resulting in carcinomatous and sarcomatous components, or…
View article: #597 Possible epigenetic changes that could drive platinum resistance in high grade serous ovarian carcinoma: data from an in-vitro treatment model
#597 Possible epigenetic changes that could drive platinum resistance in high grade serous ovarian carcinoma: data from an in-vitro treatment model Open
Introduction/Background The prognosis and therapeutic options for patients with platinum-resistant ovarian High Grade Serous Carcinoma (HGSC) remain poor. BriTROC-1 data already indicate that genomic alterations alone cannot explain acquir…
View article: The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma
The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma Open
The drivers of recurrence and resistance in ovarian high grade serous carcinoma remain unclear. We investigate the acquisition of resistance by collecting tumour biopsies from a cohort of 276 women with relapsed ovarian high grade serous c…
View article: Heme oxygenase-1 expressing omental macrophages as a therapeutic target in ovarian high grade serous carcinoma
Heme oxygenase-1 expressing omental macrophages as a therapeutic target in ovarian high grade serous carcinoma Open
Ovarian high grade serous carcinoma (HGSC) remains a disease of poor prognosis that is unresponsive to current immune checkpoint inhibitors. Although PI3K pathway alterations are common in HGSC, attempts to target this pathway have been un…