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View article: All-Cause and Exacerbation-Related Readmissions in Thrombotic Microangiopathy Requiring Plasmapheresis: A Population-Based Cohort Study
All-Cause and Exacerbation-Related Readmissions in Thrombotic Microangiopathy Requiring Plasmapheresis: A Population-Based Cohort Study Open
These findings highlight the need for improved post-discharge care and treatment strategies to prevent readmissions. Further studies should explore interventions to reduce exacerbation-related readmissions, particularly in high-risk popula…
View article: Use of PHQ-4 Tool to Assess Anxiety and Depression in Adolescents and Adults in Medically Underserved Santo Domingo, Ecuador
Use of PHQ-4 Tool to Assess Anxiety and Depression in Adolescents and Adults in Medically Underserved Santo Domingo, Ecuador Open
Background: Anxiety and depression are prevalent mental health conditions, yet they often remain underdiagnosed, especially in underserved populations. In Ecuador, mental health disorders are a significant public health concern, with limit…
View article: The ACTH test fails to diagnose adrenal insufficiency and augments cytokine production in sepsis
The ACTH test fails to diagnose adrenal insufficiency and augments cytokine production in sepsis Open
The adrenocorticotropic hormone (ACTH) test diagnoses relative adrenal insufficiency (RAI) or critical illness-related corticosteroid insufficiency (CIRCI). Initially, guidelines recommended corticosteroid/glucocorticoid (GC) therapy for s…
View article: Relative Adrenal Insufficiency Is a Risk Factor for Pediatric Sepsis: A Proof-of-Concept Study
Relative Adrenal Insufficiency Is a Risk Factor for Pediatric Sepsis: A Proof-of-Concept Study Open
Glucocorticoid (GC) therapy had been strongly recommended for pediatric sepsis (grade 1A). However, the recommendation was changed to grade 2C in 2020 due to weak evidence. About 32.8% of patients with pediatric septic develop relative adr…
View article: Structural differences between the closely related RNA helicases, UAP56 and URH49 fashions distinct functional apo-complexes
Structural differences between the closely related RNA helicases, UAP56 and URH49 fashions distinct functional apo-complexes Open
Messenger RNA export is a regulated pathway that control gene expression and specific physiological events. In humans, closely related RNA helicases, UAP56 and URH49 shape selective mRNA export pathways through distinct apo-complex formati…
View article: The adrenal stress response is an essential host response against therapy-induced lethal immune activation
The adrenal stress response is an essential host response against therapy-induced lethal immune activation Open
Cytokine release syndrome (CRS) is a systemic inflammatory syndrome associated with infection- or drug-induced T cell activation and can cause multiple organ failure and even death. Because current treatments are ineffective in some patien…
View article: Relative adrenal insufficiency is a risk factor and endotype of sepsis - A proof-of-concept study to support a precision medicine approach to guide glucocorticoid therapy for sepsis
Relative adrenal insufficiency is a risk factor and endotype of sepsis - A proof-of-concept study to support a precision medicine approach to guide glucocorticoid therapy for sepsis Open
Introduction 25-60% of septic patients experience relative adrenal insufficiency (RAI) and glucocorticoid (GC) is frequently used in septic patients. However, the efficacy of GC therapy and whether GC therapy should be based on the status …
View article: The MYC-YBX1 Circuit in Maintaining Stem-like Vincristine-Resistant Cells in Rhabdomyosarcoma
The MYC-YBX1 Circuit in Maintaining Stem-like Vincristine-Resistant Cells in Rhabdomyosarcoma Open
Rhabdomyosarcoma (RMS) is a devastating pediatric soft tissue sarcoma with no effective therapy for relapsed disease. There is limited knowledge on the mechanisms underlying treatment failures. We demonstrated that treatment of RMS cells w…
View article: SR-BI (Scavenger Receptor BI), Not LDL (Low-Density Lipoprotein) Receptor, Mediates Adrenal Stress Response—Brief Report
SR-BI (Scavenger Receptor BI), Not LDL (Low-Density Lipoprotein) Receptor, Mediates Adrenal Stress Response—Brief Report Open
Objective: Adrenal gland secretes stress-induced glucocorticoids (iGCs) to coping with stress. Previous study showed that SR-BI (scavenger receptor BI) null (SR-BI −/− ) mice failed to generate iGC in stress conditions, suggesting that SR-…
View article: Deficiency in reverse cholesterol transport in mice augments sepsis
Deficiency in reverse cholesterol transport in mice augments sepsis Open
Background Sepsis claims over 215,000 lives and costs $16.7 billion per year in America alone. Recent studies revealed that HDL receptor scavenger receptor BI (SR-BI or Scarb1) plays a critical protective role in sepsis. Using Scarb1I179N …
View article: Disseminated Cryptococcosis with Adrenal Insufficiency and Meningitis in an Immunocompetent Individual
Disseminated Cryptococcosis with Adrenal Insufficiency and Meningitis in an Immunocompetent Individual Open
We present a case of cryptococcosis with adrenal insufficiency and meningitis in a healthy host without any risk factors. Antifungal therapy did not reduce the cryptococcal antigen titers of the cerebrospinal fluid and serum or the bilater…