Explanipedia

<span>HPV6</span>‐Induced Gene Expression Signature in Recurrent Respiratory Papillomatosis Open

Naoyuki Matsumoto, Satoshi Ueha, Rumi Ueha, Misaki Koyama, Kaoru Yamakawa , et al. · 2025

Objectives Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11. However, the cellular and molecular mechanisms underlying its pathogenesis remain to be elucidated. Recently, the conditional rep…

Improved Pharyngeal Contraction and Oral Intake Status After Modified Central‐Part Laryngectomy for Late‐Stage ALS Open

Rumi Ueha, Maria Angela Dealino, Misaki Koyama, Kaoru Yamakawa, Naoyuki Matsumoto , et al. · 2025

Objective To investigate the effects of modified central‐part laryngectomy with pharyngeal space reduction (CPL‐PR) on patients with weak deglutitive pharyngeal contraction, as seen in late‐stage amyotrophic lateral sclerosis (ALS). Study …

Resolution of long-lasting laryngeal manifestations using glucocorticoids and tumor necrosis factor-α inhibitor therapy in a patient with mouth and genital ulcers with inflamed cartilage syndrome Open

Tomohiro SUZUKI, Toshihiko Komai, Misaki Koyama, Kento Koda, Rumi Ueha , et al. · 2025

Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome is a rare disorder characterized by features of both relapsing polychondritis (RP) and Behçet's disease (BD), with multi-organ involvement, including inflammation and destru…

Velopharyngeal Insufficiency and Impaired Tongue Movement Indicate Neuromuscular Disorders: A 10-Year Statistical Study in a Single Tertiary Institution Open

Aiko Fujisaki, Rumi Ueha, Carmel Cotaoco, Misaki Koyama, Taku Sato , et al. · 2025

Objectives: This study aimed to determine the positive predictive value of our NMD Suspicion Criteria in the diagnosis of NMDs. Other clinical factors routinely examined in our voice and swallowing examinations were also investigated to se…

Esophageal Dysmotility in Multiple System Atrophy: A Retrospective Cross-Sectional Study Open

Rumi Ueha, Misaki Koyama, Akiko Seto, Taku Sato, Takao Goto , et al. · 2024

Background/Objective: Multiple system atrophy (MSA) is often associated with dysphagia and esophageal dysmotility (ED). However, ED in patients with MSA is poorly understood. To assess the relationship between ED, dysphagia, and other clin…

Severe Dysphagia in a Patient with Wallenberg Syndrome and Killian Jamieson Diverticulum: A Case Report Open

Carmel Cotaoco, Takao Goto, Misaki Koyama, Taku Sato, Kenji Kondo , et al. · 2024

Lateral medullary syndrome (Wallenberg syndrome) and Killian Jamieson diverticulum are both conditions known to cause dysphagia. Here, we present the first reported case of severe dysphagia due to Wallenberg syndrome and a Killian Jamieson…

Severe Dysphagia in a Patient with Wallenberg Syndrome and Killian Jamieson Diverticulum: A Case Report Open

Carmel Cotaoco, Takao Goto, Misaki Koyama, Taku Sato, Kenji Kondo , et al. · 2024

Introduction Lateral medullary syndrome (Wallenberg syndrome) and Killian Jamieson diverticulum are both conditions known to cause dysphagia. Here we present the first reported case of severe dysphagia due to Wallenberg syndrome and a Kill…

Three-dimensional Computed Tomography Features of Recurrent Laryngeal Nerve Paralysis Due to Aortic Aneurysm Open

Jumpei Sasakawa, Takao Goto, Taku Sato, Misaki Koyama, Rumi Ueha , et al. · 2024

Detailed reports on the stretching and compression of the recurrent laryngeal nerve by aortic aneurysms are unavailable. Therefore, we evaluated three-dimensional computed tomography images of patients with aortic aneurysm-associated recur…

Swallowing improvement surgeries Open

Carmel Cotaoco, Rumi Ueha, Misaki Koyama, Taku Sato, Takao Goto , et al. · 2024

Comparison of changes in oxygen concentrations depending on oxygen administration site in for home NPPV devise Open

Misaki Koyama · 2024

Hearing and Hearing Loss Progression in Patients with GJB2 Gene Mutations: A Long-Term Follow-Up Open

Aki Sakata, Akinori Kashio, Misaki Koyama, Shinji Urata, Hajime Koyama , et al. · 2023

We aimed to investigate whether the degree of hearing loss with GJB2 mutations could be predicted by distinguishing between truncating and non-truncating mutations and whether the genotype could predict the hearing loss level. Additionally…

Differences in residual volume above different tracheostomy tube cuffs depending on tube structure, tube tilt angle, and liquid viscosity Open

Takahiro Katsuno, Rumi Ueha, Aiko Fujisaki, Takeshi Unno, Carmel Cotaoco , et al. · 2023

Characteristics of pregnancy complicated with type 1 and type 2 diabetes Open

Misaki Koyama, Mana Taki, Haruko Okamoto, Yosuke Kawamura, Yusuke Ueda , et al. · 2023

Objective: Diabetes in pregnancy is a major risk factor for adverse perinatal outcomes such as congenital anomalies, hypertensive disorders of pregnancy (HDP), and macrosomia. For the mechanism of onset of type 1 and type 2 diabetes are di…

Subglottic Laryngeal Closure for a Child with Rett Syndrome Open

Ayaka Otsuka, Rumi Ueha, Takao Goto, Misaki Koyama, Taku Sato , et al. · 2023

Various types of aspiration prevention surgeries have been developed, and this surgery is considered to be indicated in children with recurrent aspiration pneumonia. We herein report a pediatric case of Rett syndrome in which subglottic la…

Correction: Aspiration prevention surgeries: a review Open

Rumi Ueha, Redentor B Magdayao, Misaki Koyama, Taku Sato, Takao Goto , et al. · 2023

Aspiration prevention surgeries: a review Open

Rumi Ueha, Redentor B Magdayao, Misaki Koyama, Taku Sato, Takao Goto , et al. · 2023

Background Severe dysphagia can cause intractable pneumonia and lead to life-threatening conditions. Intractable aspiration can occur despite medical management for aspiration prevention. Surgical intervention is indicated for intractable …

ATM mutation in aggressive uterine adenosarcoma in which systemic chemotherapies had remarkable effects Open

Misaki Koyama, Ken Yamaguchi, Yoshitsugu Chigusa, Koji Yamanoi, Mana Taki , et al. · 2023

Oral SARS-CoV-2 Inoculation Causes Nasal Viral Infection Leading to Olfactory Bulb Infection: An Experimental Study Open

Rumi Ueha, Toshihiro Ito, Ryutaro Furukawa, Masahiro Kitabatake, Noriko Ouji-Sageshima , et al. · 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can cause long-lasting anosmia, but the impact of SARS-CoV-2 infection, which can spread to the nasal cavity via the oral route, on the olfactory receptor neuron (ORN)…

Oral SARS-CoV-2 Inoculation Causes Nasal Viral Infection Leading to Olfactory Bulb Infection: an Experimental Study Open

Rumi Ueha, Toshihiro Ito, Ryutaro Furukawa, Masahiro Kitabatake, Noriko Ouji-Sageshima , et al. · 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can cause long-lasting anosmia, but the impact of SARS-CoV-2 infection, which can spread to the nasal cavity via the oral route, on the olfactory receptor neuron (ORN)…

Effects of Aspiration Prevention Surgery on the Dynamics of the Pharynx and Upper Esophageal Sphincter Open

Rumi Ueha, Taku Sato, Takao Goto, Misaki Koyama, Akihito Yamauchi , et al. · 2021

Objective Oral intake after aspiration prevention surgery (APS) is influenced by postoperative pharyngeal pressure and the dynamics of the upper esophageal sphincter (UES). We examined the effects of less invasive APS combined with UES rel…

Risk Factors for Aspiration Pneumonia After Receiving Liquid‐Thickening Recommendations Open

H. Masuda, Rumi Ueha, Taku Sato, Takao Goto, Misaki Koyama , et al. · 2021

Objective We examined the influence of liquid thickness levels on the frequency of liquid penetration‐aspiration in patients with dysphagia and evaluated the clinical risk factors for penetration‐aspiration and aspiration pneumonia develop…

An Adult Case of Pott’s Puffy Tumor after Finger-pressure Therapy Open

Misaki Koyama, Makoto Kinoshita, Kyohei Horikiri, Megumi Kishimoto, Shu Kikuta , et al. · 2020

Pottʼs puffy tumor(以下PPT)とは前頭骨骨髄炎に伴い前額部に皮下膿瘍を形成し，腫瘤状の軟らかい腫脹をきたす疾患概念である

Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats Open

Masato Kanazawa, Minami Miura, Masafumi Toriyabe, Misaki Koyama, Masahiro Hatakeyama , et al. · 2017

Methylmercury Causes Blood-Brain Barrier Damage in Rats via Upregulation of Vascular Endothelial Growth Factor Expression Open

Tetsuya Takahashi, Masatake Fujimura, Misaki Koyama, Masato Kanazawa, Fusako Usuki , et al. · 2017

Clinical manifestations of methylmercury (MeHg) intoxication include cerebellar ataxia, concentric constriction of visual fields, and sensory and auditory disturbances. The symptoms depend on the site of MeHg damage, such as the cerebellum…

Increased cytoplasmic<i>TARDBP</i>mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43 Open

Akihide Koyama, Akihiro Sugai, Taisuke Kato, Tomohiko Ishihara, Atsushi Shiga , et al. · 2016

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder. In motor neurons of ALS, TAR DNA binding protein-43 (TDP-43), a nuclear protein encoded by TARDBP, is absent from the nucleus and forms cytoplasmic inclusions. TDP-43 au…

Multiple therapeutic effects of a growth factor, progranulin on ischemic brain injury Open

Takayoshi Shimohata, Masato Kanazawa, Masafumi Toriyabe, Misaki Koyama, Tetsuya Takahashi , et al. · 2016

我々は，脳梗塞に対する組織プラスミノゲン・アクチベーター（t-PA）療法に併用し，予後を改善する薬剤の開発を目指している．成長因子プログラニュリン（PGRN）に注目し検討を行ったところ，脳虚血後の著明な発現増加が確認され，虚血中心ではミクログリア，ペナンブラでは神経細胞がその産生を担っていた．脳虚血におけるPGRN の役割を確認するため，PGRN KO マウスとt-PA 投与脳塞栓モデルを用いた検証を行ったところ，PGRN の欠乏は脳梗塞の増悪，逆にPGRN 投与は脳保護的…

Short-term hypoglycemic coma model. Open

Tetsuhiko Ikeda, Tetsuya Takahashi, Mika Tsujita, Masato Kanazawa, Masafumi Toriyabe , et al. · 2015

(A) Protocol for hypoglycemic loading and induction of the hyperglycemic state. Rapid-acting insulin was intraperitoneally administered at a dose of 15 IU/kg. After 2 or 10 min of the presence of an isoelectric electroencephalogram (EEG), …

Fluoro-Jade B-positive cells in the short-term hypoglycemic coma model. Open

Tetsuhiko Ikeda, Tetsuya Takahashi, Mika Tsujita, Masato Kanazawa, Masafumi Toriyabe , et al. · 2015

(A) Representative images of Fluoro-Jade B-positive cells in the sham group, the 2-min isoelectric EEG (iso-EEG) group, and the 10-min isoelectric EEG group. Scale bar: 100 μm. (B) The number of Fluoro-Jade B-positive cells in the sham gro…

Distribution of 4-HNE-positive cells in the short-term hypoglycemic coma model. Open

Tetsuhiko Ikeda, Tetsuya Takahashi, Mika Tsujita, Masato Kanazawa, Masafumi Toriyabe , et al. · 2015

(A) Representative images of 4-HNE-positive cells in the sham group, the 2-min isoelectric EEG (iso-EEG) group, and the 10-min isoelectric EEG group. Higher magnification views of 4-HNE-positive cells are shown in the small frames. Scale b…

Effects of Alda-1 on Fluoro-Jade B-positive cells. Open

Tetsuhiko Ikeda, Tetsuya Takahashi, Mika Tsujita, Masato Kanazawa, Masafumi Toriyabe , et al. · 2015

(A) Representative images of Fluoro-Jade B-positive cells treated with vehicle (DMSO) or Alda-1. Scale bar: 100 μm. (B) Number of Fluoro-Jade B-positive cells in groups treated with vehicle (DMSO) or Alda-1. Data are means ± SD (n =…

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