Misao Takano
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View article: Clustering of Polymorphic Membrane Protein E Clade in <i>Chlamydia trachomatis</i> Lineages from Men who Have Sex with Men
Clustering of Polymorphic Membrane Protein E Clade in <i>Chlamydia trachomatis</i> Lineages from Men who Have Sex with Men Open
Several Chlamydia trachomatis lineages identified through outer membrane protein A genotyping or multilocus sequence typing have been circulating worldwide among men who have sex with men. In a study in Tokyo, Japan, we demonstrate that su…
View article: 2662. Efficacy of Sitafloxacin and Doxycycline Combination Therapy as a Salvage Treatment for Refractory <i>Mycoplasma genitalium</i> Infection
2662. Efficacy of Sitafloxacin and Doxycycline Combination Therapy as a Salvage Treatment for Refractory <i>Mycoplasma genitalium</i> Infection Open
Background The prevalence of resistant strains of Mycoplasma genitalium has increased over the past few decades, leading to limited treatment options. This study aimed to evaluate the efficacy of sitafloxacin and doxycycline combination th…
View article: Efficacy and Safety of Pre-Exposure Prophylaxis to Control HIV and Sexually Transmitted Infection Among Men Who Have Sex With Men: Protocol for a Single-Arm Interventional Study
Efficacy and Safety of Pre-Exposure Prophylaxis to Control HIV and Sexually Transmitted Infection Among Men Who Have Sex With Men: Protocol for a Single-Arm Interventional Study Open
Background Pre-exposure prophylaxis (PrEP) against HIV infection is a new approach that involves the prophylactic use of the anti-HIV drug Truvada (tenofovir disoproxil fumarate [TDF] and emtricitabine [FTC]) by people not infected with HI…
View article: Sitafloxacin- Versus Moxifloxacin-Based Sequential Treatment for Mycoplasma Genitalium Infections: Protocol for a Multicenter, Open-Label Randomized Controlled Trial
Sitafloxacin- Versus Moxifloxacin-Based Sequential Treatment for Mycoplasma Genitalium Infections: Protocol for a Multicenter, Open-Label Randomized Controlled Trial Open
Background Mycoplasma genitalium is an emerging sexually transmitted pathogen associated with increasing antibiotic resistance. The current treatment guidelines recommend moxifloxacin-sequential therapy for macrolide-resistant Mgenitalium …
View article: Efficacy of Lactococcus lactis strain Plasma on clearance of anal HPV infection in men who have sex with men: A single-center, double-blinded, randomized placebo-controlled trial (CLEAR HPV study)
Efficacy of Lactococcus lactis strain Plasma on clearance of anal HPV infection in men who have sex with men: A single-center, double-blinded, randomized placebo-controlled trial (CLEAR HPV study) Open
Background: Anal cancer is a human papillomavirus-related cancer; specifically, it is preceded by high-grade squamous intraepithelial lesions, which are less likely to regress spontaneously than low-grade intraepithelial lesions. Although …
View article: Electrocautery ablation of high-grade anal intraepithelial lesions: A protocol for a clinical trial
Electrocautery ablation of high-grade anal intraepithelial lesions: A protocol for a clinical trial Open
Background: Anal cancer is predominantly caused by the human papillomavirus. The use of high-resolution anoscopy (HRA) for screening, followed by appropriate therapeutic interventions, is progressively being acknowledged as a standardized …
View article: Sitafloxacin- Versus Moxifloxacin-Based Sequential Treatment for Mycoplasma Genitalium Infections: Protocol for a Multicenter, Open-Label Randomized Controlled Trial (Preprint)
Sitafloxacin- Versus Moxifloxacin-Based Sequential Treatment for Mycoplasma Genitalium Infections: Protocol for a Multicenter, Open-Label Randomized Controlled Trial (Preprint) Open
BACKGROUND Mycoplasma genitalium is an emerging sexually transmitted pathogen associated with increasing antibiotic resistance. The current treatment guidelines recommend moxifloxacin-sequential therapy for macrolide-resistant M…
View article: Prevalence of Asymptomatic Mpox among Men Who Have Sex with Men, Japan, January–March 2023
Prevalence of Asymptomatic Mpox among Men Who Have Sex with Men, Japan, January–March 2023 Open
We prospectively assessed asymptomatic monkeypox virus infections among men who have sex with men in Tokyo, Japan, during the initial phase of the mpox epidemic. Our findings suggest that asymptomatic infections were likely underestimated …
View article: Effectiveness of sitafloxacin monotherapy for quinolone-resistant rectal and urogenital <i>Mycoplasma genitalium</i> infections: a prospective cohort study
Effectiveness of sitafloxacin monotherapy for quinolone-resistant rectal and urogenital <i>Mycoplasma genitalium</i> infections: a prospective cohort study Open
Background Mycoplasma genitalium has a tendency to develop macrolide and quinolone resistance. Objectives We investigated the microbiological cure rate of a 7 day course of sitafloxacin for the treatment of rectal and urogenital infections…
View article: Effect of tenofovir-based HIV pre-exposure prophylaxis against HBV infection in men who have sex with men
Effect of tenofovir-based HIV pre-exposure prophylaxis against HBV infection in men who have sex with men Open
Background and Aims: Men who have sex with men (MSM) are vulnerable to contracting HBV as a sexually transmitted infection. We evaluated the incidence of HBV infection (HBI) and the prophylactic effect of tenofovir-based pre-exposure proph…
View article: Pharmacokinetics of Bictegravir in Older Japanese People Living with HIV-1
Pharmacokinetics of Bictegravir in Older Japanese People Living with HIV-1 Open
BIC is a potent integrase strand transfer inhibitor (INSTI), widely used for the treatment of HIV-1 as part of a once-daily single-tablet regimen that includes emtricitabine and tenofovir alafenamide (BIC+FTC+TAF). Although the safety and …
View article: Electrocautery ablation therapy for anal intraepithelial carcinoma: A study protocol
Electrocautery ablation therapy for anal intraepithelial carcinoma: A study protocol Open
Background: Anal cancer is a human papillomavirus-related cancer. Screening with high-resolution anoscopy (HRA) and subsequent therapeutic intervention are increasingly recognized as the standard procedure for anal cancer. Generally, lesio…
View article: Identification of asymptomatic Entamoeba histolytica infection by a serological screening test: A cross-sectional study of an HIV-negative men who have sex with men cohort in Japan
Identification of asymptomatic Entamoeba histolytica infection by a serological screening test: A cross-sectional study of an HIV-negative men who have sex with men cohort in Japan Open
Background Amebiasis, caused by Entamoeba histolytica , is spreading in developing countries and in many developed countries as a sexually transmitted infection. Here, we evaluated the efficacy of serological screening to identify asymptom…
View article: Evaluating the cost-effectiveness of a pre-exposure prophylaxis program for HIV prevention for men who have sex with men in Japan
Evaluating the cost-effectiveness of a pre-exposure prophylaxis program for HIV prevention for men who have sex with men in Japan Open
Men who have sex with men (MSM) have been disproportionally affected by the HIV epidemic in many countries, including Japan. Although pre-exposure prophylaxis (PrEP) is a strong prevention tool, it is not yet approved in Japan. A Markov mo…
View article: Clinical Effectiveness of Sitafloxacin Monotherapy for Treating Rectal and Urogenital <i>Mycoplasma Genitalium</i> Infections in a Setting with a High Prevalence of Quinolone Resistance-Associated Mutations: A Single Center, Prospective Cohort Study
Clinical Effectiveness of Sitafloxacin Monotherapy for Treating Rectal and Urogenital <i>Mycoplasma Genitalium</i> Infections in a Setting with a High Prevalence of Quinolone Resistance-Associated Mutations: A Single Center, Prospective Cohort Study Open
View article: Validation of mailed <i>via</i> postal service dried blood spot cards on commercially available HIV testing systems
Validation of mailed <i>via</i> postal service dried blood spot cards on commercially available HIV testing systems Open
The demand for HIV testing using dried blood spots (DBS) has increased recently. However, DBS is not an approved sample for HIV testing in Japan. This study examined the validation of HIV testing with DBS, prepared at the laboratory or rem…
View article: Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan
Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan Open
View article: High prevalence of circulating dual-class resistant <i>Mycoplasma genitalium</i> in asymptomatic MSM in Tokyo, Japan
High prevalence of circulating dual-class resistant <i>Mycoplasma genitalium</i> in asymptomatic MSM in Tokyo, Japan Open
Objectives To assess the prevalence and antibiotic resistance profile of Mycoplasma genitalium detected from urogenital/rectal swab samples obtained from MSM in Tokyo, Japan. Methods We performed PCR-based screening for M. genitalium uroge…
View article: Anal human papillomavirus infection and its relations with abnormal anal cytology among MSM with or without HIV infection in Japan
Anal human papillomavirus infection and its relations with abnormal anal cytology among MSM with or without HIV infection in Japan Open
Background Anorectal high-risk human papillomavirus (hr-HPV) infection is associated with anal malignancies. However, the epidemiological data is quite limited in Japan. Methods Anorectal swab was obtained from HIV-infected and –uninfected…
View article: Evaluating the Cost-Effectiveness of a Pre-Exposure Prophylaxis Program for HIV Prevention for Men Who Have Sex with Men in Japan
Evaluating the Cost-Effectiveness of a Pre-Exposure Prophylaxis Program for HIV Prevention for Men Who Have Sex with Men in Japan Open
View article: Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients
Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients Open
This single-institution cross-sectional study aimed to grasp the prevalence and features of neurocognitive dysfunction in HIV-infected hemophilia patients in Japan. We conducted neuropsychological tests and medical examinations in 56 HIV-i…
View article: Prevalence and incidence of HIV-1 infection in a community-based men who have sex with men (MSM) cohort in Ulaanbaatar, Mongolia
Prevalence and incidence of HIV-1 infection in a community-based men who have sex with men (MSM) cohort in Ulaanbaatar, Mongolia Open
The number of HIV-1-infected men who have sex with men (MSM) Mongolian patients started to increase steeply just before 2011. We started collaborative work with community-based organizations that promote safer sex and HIV testing for MSM s…
View article: Pathogenesis, clinical course, and recent issues in HIV-1-infected Japanese hemophiliacs: a three-decade follow-up
Pathogenesis, clinical course, and recent issues in HIV-1-infected Japanese hemophiliacs: a three-decade follow-up Open
Nearly 30% of Japanese hemophiliacs were infected with HIV-1 in the early 1980s. They have unique characteristics compared to HIV-1-infected individuals through other routes, including date of infection of 1986 or earlier, mean age of near…
View article: High prevalence and incidence of rectal Chlamydia infection among men who have sex with men in Japan
High prevalence and incidence of rectal Chlamydia infection among men who have sex with men in Japan Open
The prevalence and incidence of rectal CT/NG were high among MSM in Tokyo, Japan, suggesting that urgent countermeasures for early diagnosis and treatment are necessary.
View article: Non-AIDS-defining malignancies in Japanese hemophiliacs with HIV-1 infection
Non-AIDS-defining malignancies in Japanese hemophiliacs with HIV-1 infection Open
Along improvement of prognosis of HIV-1-infected patients due to successful anti-retroviral therapy, main causes of death in the patients have been changing from AIDS to non-AIDS defining malignancies (NADM) recently. However, little is kn…
View article: P526 High prevalence and incidence rate of rectal chlamydia and gonorrhoea infection among men who have sex with men in tokyo
P526 High prevalence and incidence rate of rectal chlamydia and gonorrhoea infection among men who have sex with men in tokyo Open
Background Rectal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection have been neglected and epidemiological data is not available in Japan. Thus, we evaluated prevalence and incidence of rectal CT and NG in …
View article: P556 History of STI therapy and willingness of PrEP among HIV-negative MSM cohort in japan
P556 History of STI therapy and willingness of PrEP among HIV-negative MSM cohort in japan Open
Background Pre-exposure prophylaxis (PrEP) is not yet approved and information of PrEP is still very limited in Japan. In such circumstances, we established an HIV-negative MSM cohort at National Center for Global Health and Medicine, Toky…
View article: Assessment of HIV prevalence among MSM in Tokyo using self-collected dried blood spots delivered through the postal service
Assessment of HIV prevalence among MSM in Tokyo using self-collected dried blood spots delivered through the postal service Open
This study was registered with the University Hospital Medical Information Network Clinical Trial Registry in August 20th, 2015 (Registry number: UMIN000018699 ).
View article: Additional file 3: of Assessment of HIV prevalence among MSM in Tokyo using self-collected dried blood spots delivered through the postal service
Additional file 3: of Assessment of HIV prevalence among MSM in Tokyo using self-collected dried blood spots delivered through the postal service Open
Table S2A. The intra-assay valiability. Table S2B. The inter-assay valiability. Table S2C. Sensitivity analysis with diluted samples. Table S2D. Association of C.O.I using eluted DBS and serum sample. (ZIP 31 kb)
View article: The second molecular epidemiological study of HIV infection in Mongolia between 2010 and 2016
The second molecular epidemiological study of HIV infection in Mongolia between 2010 and 2016 Open
HIV-1 infection might expand to the general population in Mongolia. Our study documented a new cluster of HIV-1 transmission, enhancing our understanding of the epidemiological status of HIV-1 in Mongolia.