Mischa Zelzer
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View article: Making in vitro release and formulation data AI-ready: A foundation for streamlined nanomedicine development
Making in vitro release and formulation data AI-ready: A foundation for streamlined nanomedicine development Open
Machine learning and artificial intelligence (AI) is transforming the way pharmaceutical products are developed across drug discovery, process engineering, and pharmaceutics functions. AI for nanomedicine development is enabling faster and…
View article: A machine learning workflow to accelerate the design of <i>in vitro</i> release tests from liposomes
A machine learning workflow to accelerate the design of <i>in vitro</i> release tests from liposomes Open
A machine learning workflow was developed to predict liposome drug release profiles, enabling accelerated design of in vitro release tests.
View article: Cellular and microenvironmental cues that promote macrophage fusion and foreign body response
Cellular and microenvironmental cues that promote macrophage fusion and foreign body response Open
During the foreign body response (FBR), macrophages fuse to form foreign body giant cells (FBGCs). Modulation of FBGC formation can prevent biomaterial degradation and loss of therapeutic efficacy. However, the microenvironmental cues that…
View article: PLGA‐PEG‐PLGA hydrogels induce cytotoxicity in conventional in vitro assays
PLGA‐PEG‐PLGA hydrogels induce cytotoxicity in conventional in vitro assays Open
Significance statement We identified that PLGA‐PEG‐PLGA hydrogels, which have been used in human clinical trials and possess a demonstrable safety profile, induced significant cytotoxicity in conventional in vitro assays. This major contra…
View article: Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from <i>Haloferax volcanii</i> in aqueous ionic liquid solvent mixtures
Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from <i>Haloferax volcanii</i> in aqueous ionic liquid solvent mixtures Open
Cooperative ion–ion interactions drive the selectivity of ion–protein interactions for the halophilic protein ADH in aqueous solutions, with water molecules tightly bound to acidic residues playing an influential role.
View article: Ion-combination specific effects driving enzymatic activity of halophilic Alcohol Dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures
Ion-combination specific effects driving enzymatic activity of halophilic Alcohol Dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures Open
Biocatalysis in ionic liquids enables novel routes for bioprocessing. Enzymes derived from extremophiles promise greater stability and activity under ionic liquid (IL) influence. Here, we probe the enzyme Alcohol Dehydrogenase 2 from the h…
View article: Processing and interpretation of core‐electron XPS spectra of complex plasma‐treated polyethylene‐based surfaces using a theoretical peak model
Processing and interpretation of core‐electron XPS spectra of complex plasma‐treated polyethylene‐based surfaces using a theoretical peak model Open
Interpretation of X‐ray photoelectron spectroscopy (XPS) spectra of complex material surfaces, such as those obtained after surface plasma treatment of polymers, is confined by the available references. The limited understanding of the che…
View article: Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration
Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration Open
View article: Cell-controlled dynamic surfaces for skeletal stem cell growth and differentiation
Cell-controlled dynamic surfaces for skeletal stem cell growth and differentiation Open
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Quantifiable correlation of ToF‐SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content
Quantifiable correlation of ToF‐SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content Open
Peptide‐coated surfaces are widely employed in biomaterial design, but quantifiable correlation between surface composition and biological response is challenging due to, for example, instrumental limitations, a lack of suitable model surf…
View article: A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus
A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus Open
The study illustrates feasibility of the proposed concept where intracellular drug release from mechanoresponsive liposomes can be triggered on demand by external ultrasound stimulus.
View article: Surface-controlled spatially heterogeneous physical properties of a supramolecular gel with homogeneous chemical composition
Surface-controlled spatially heterogeneous physical properties of a supramolecular gel with homogeneous chemical composition Open
A mechanical pattern is created in a hydrogel film by pre-patterning the underlying surface chemistry. This allows spatial variation of the viscous component of the gel, controlling dissipative forces in the gel film without altering gel c…
View article: Selective modification of Ti6Al4V surfaces for biomedical applications
Selective modification of Ti6Al4V surfaces for biomedical applications Open
The surface of a medical implant is required to interact favourably with ions, biomolecules and cells in vivo, commonly resulting in the formation of the extracellular matrix.
View article: Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo
Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo Open
Supramolecular gels have recently emerged as promising biomaterials for the delivery of a wide range of bioactive molecules, from small hydrophobic drugs to large biomolecules such as proteins. Although it has been demonstrated that each e…
View article: Correction to “Supramolecular Nucleoside-Based Gel: Molecular Dynamics Simulation and Characterization of Its Nanoarchitecture and Self-Assembly Mechanism”
Correction to “Supramolecular Nucleoside-Based Gel: Molecular Dynamics Simulation and Characterization of Its Nanoarchitecture and Self-Assembly Mechanism” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Supramolecular Nucleoside-Based Gel: Molecular Dynamics Simulation and Characterization of Its Nanoarchitecture and Self-Asse…
View article: Low Molecular Weight Nucleoside Gelators: A Platform for Protein Aggregation Inhibition
Low Molecular Weight Nucleoside Gelators: A Platform for Protein Aggregation Inhibition Open
Low molecular weight nucleoside gelators hold great promise in drug delivery and particularly for the delivery of biologics because of their excellent biocompatibility. However, the influence of these gelators on protein aggregation inhibi…
View article: Surface-Mediated Supramolecular Self-Assembly of Protein, Peptide, and Nucleoside Derivatives: From Surface Design to the Underlying Mechanism and Tailored Functions
Surface-Mediated Supramolecular Self-Assembly of Protein, Peptide, and Nucleoside Derivatives: From Surface Design to the Underlying Mechanism and Tailored Functions Open
Among the many parameters that have been explored to exercise control over self-assembly processes, the influence of surface properties on self-assembly has been recognized as important but has received considerably less attention than oth…
View article: Supramolecular Nucleoside-Based Gel: Molecular Dynamics Simulation and Characterization of Its Nanoarchitecture and Self-Assembly Mechanism
Supramolecular Nucleoside-Based Gel: Molecular Dynamics Simulation and Characterization of Its Nanoarchitecture and Self-Assembly Mechanism Open
Among the diversity of existing supramolecular hydrogels, nucleic acid-based hydrogels are of particular interest for potential drug delivery and tissue engineering applications because of their inherent biocompatibility. Hydrogel performa…
View article: Hydrophobicity of surface-immobilised molecules influences architectures formed <i>via</i> interfacial self-assembly of nucleoside-based gelators
Hydrophobicity of surface-immobilised molecules influences architectures formed <i>via</i> interfacial self-assembly of nucleoside-based gelators Open
Driving factors for surface-controlled self assembly are investigated by correlating surface parameters with changes in gel fibre diameters.
View article: Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation
Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation Open
Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative cells and growing large numbers of stem cells for clinical use chal…
View article: Tuning the conformation of synthetic co-polypeptides of serine and glutamic acid through control over polymer composition
Tuning the conformation of synthetic co-polypeptides of serine and glutamic acid through control over polymer composition Open
Ring opening polymerization (ROP) of N‐carboxy anhydride (NCA) amino acids presents a rapid way to synthesize high molecular weight polypeptides with different amino acid compositions. The compositional and functional versatility of polype…
View article: Surface-directed modulation of supramolecular gel properties
Surface-directed modulation of supramolecular gel properties Open
Surface properties directly affect fibre architecture and stiffness of self-assembled cytidine based gel films.
View article: Analysis of enzyme-responsive peptide surfaces by Raman spectroscopy
Analysis of enzyme-responsive peptide surfaces by Raman spectroscopy Open
Detection of enzymatic hydrolysis of peptide surfaces by Raman spectroscopy.
View article: Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks
Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks Open
Here, we demonstrate that by using a training set approach principal components analysis (PCA) can be performed on large 3D ToF-SIMS images of neuronal cell cultures.
View article: 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling
3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling Open
Hydrogels have been used extensively in bioengineering as artificial cell culture supports. Investigation of the interrelationship between cellular response to the hydrogel and its chemistry ideally requires methods that allow characteriza…
View article: Responsive Cell–Material Interfaces
Responsive Cell–Material Interfaces Open
Major design aspects for novel biomaterials are driven by the desire to mimic more varied and complex properties of a natural cellular environment with man-made materials. The development of stimulus responsive materials makes considerable…