Michiko Yamato
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View article: End-to-end Anastomosis With ECHELON ENDOPATH™ Staple Line Reinforcement for Right-sided Colon Cancer: Safety and Feasibility
End-to-end Anastomosis With ECHELON ENDOPATH™ Staple Line Reinforcement for Right-sided Colon Cancer: Safety and Feasibility Open
SLR represents a safe and effective adjunctive technique for FEEA in right-sided colon cancer surgery. Further validation through larger prospective studies is warranted to confirm these preliminary results.
View article: Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models Open
Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
View article: Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models Open
Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
View article: Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models Open
B7-H3 is overexpressed in various solid tumors and has been considered as an attractive target for cancer therapy. Here, we report the development of DS-7300a, a novel B7-H3–targeting antibody–drug conjugate with a potent DNA topoisomerase…
View article: Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models Open
B7-H3 is overexpressed in various solid tumors and has been considered as an attractive target for cancer therapy. Here, we report the development of DS-7300a, a novel B7-H3–targeting antibody–drug conjugate with a potent DNA topoisomerase…
View article: Figure S1 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Figure S1 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
The B7-H3 staining pattern for diagnosis
View article: Figure S2 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Figure S2 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Effect of using a combination of targeting B7-H3 and PD-L1 on body weight in the murine tumor model
View article: Table S1 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Table S1 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Characteristics of patients treated with anti-PD-1 antibody
View article: Table S1 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Table S1 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Characteristics of patients treated with anti-PD-1 antibody
View article: Figure S2 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Figure S2 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Effect of using a combination of targeting B7-H3 and PD-L1 on body weight in the murine tumor model
View article: Data from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Data from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Purpose: Anti-programmed-death-1 (PD-1) immunotherapy improves survival in non–small cell lung cancer (NSCLC), but some cases are refractory to treatment, thereby requiring alternative strategies. B7-H3, an immune-checkpoint molecul…
View article: Table S3 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Table S3 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Cox proportional hazard model for PFS
View article: Table S2 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Table S2 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Effect of PD-L1 and B7-H3 expression on response rate
View article: Data from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Data from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Purpose: Anti-programmed-death-1 (PD-1) immunotherapy improves survival in non–small cell lung cancer (NSCLC), but some cases are refractory to treatment, thereby requiring alternative strategies. B7-H3, an immune-checkpoint molecul…
View article: Table S3 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Table S3 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Cox proportional hazard model for PFS
View article: Figure S1 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Figure S1 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
The B7-H3 staining pattern for diagnosis
View article: Table S2 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Table S2 from B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity Open
Effect of PD-L1 and B7-H3 expression on response rate
View article: DS-7300a, a novel B7-H3-targeting antibody-drug conjugate with a novel DNA topoisomerase I inhibitor DXd, exhibits potent anti-tumor effects in nonclinical models
DS-7300a, a novel B7-H3-targeting antibody-drug conjugate with a novel DNA topoisomerase I inhibitor DXd, exhibits potent anti-tumor effects in nonclinical models Open
View article: Novel anti-EPHA2 antibody, DS-8895a for cancer treatment
Novel anti-EPHA2 antibody, DS-8895a for cancer treatment Open
Overexpression of EPHA2 has been observed in multiple cancers and reported to be associated with poor prognosis. Here, we produced an afucosylated humanized anti-EPHA2 monoclonal antibody (mAb), DS-8895a for cancer treatment. The antibody …
View article: Development of <scp>DS</scp>‐5573a: A novel afucosylated <scp>mA</scp>b directed at B7‐H3 with potent antitumor activity
Development of <span>DS</span>‐5573a: A novel afucosylated <span>mA</span>b directed at B7‐H3 with potent antitumor activity Open
B7‐H3 is highly overexpressed in a variety of human clinical tumors, and its expression is significantly associated with poor outcomes. In our study, we aimed to develop new antitumor mA bs by employing cancer cell immunization, and succee…