Mitchell A. Lesko
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View article: Changing course: Glucose starvation drives nuclear accumulation of Hexokinase 2 in S. cerevisiae
Changing course: Glucose starvation drives nuclear accumulation of Hexokinase 2 in S. cerevisiae Open
Glucose is the preferred carbon source for most eukaryotes, and the first step in its metabolism is phosphorylation to glucose-6-phosphate. This reaction is catalyzed by hexokinases or glucokinases. The yeast Saccharomyces cerevisiae encod…
View article: Hexokinase 2 localizes to the nucleus in response to glucose limitation but does not regulate gene expression
Hexokinase 2 localizes to the nucleus in response to glucose limitation but does not regulate gene expression Open
Glucose is the preferred carbon source for most eukaryotes, and the first step in its metabolism is phosphorylation to glucose-6-phosphate. This reaction is catalyzed by a family of enzymes called either hexokinases or glucokinases dependi…
View article: Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics
Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics Open
Glucose is central to many biological processes, serving as an energy source and a building block for biosynthesis. After glucose enters the cell, hexokinases convert it to glucose-6-phosphate (Glc-6P) for use in anaerobic fermentation, ae…
View article: Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease
Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease Open
Potassium (K + ) homeostasis is tightly regulated for optimal cell and organismal health. Failure to control potassium balance results in disease, including cardiac arrythmias and developmental disorders. A family of inwardly rectifying po…