Mitchell S. Albert
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View article: Effect of High Zn Concentration on the Structural, Electrical, and Magnetic Properties of Zn-Doped Yttrium Iron Garnet Nanoparticles
Effect of High Zn Concentration on the Structural, Electrical, and Magnetic Properties of Zn-Doped Yttrium Iron Garnet Nanoparticles Open
Current-induced magnetoelectric (ME) effect offers the potential for broadband, low-power tunable microwave devices. While yttrium iron garnet (YIG) is the most used ferrite due to its superior magnetic properties, its high-quality dielect…
View article: Magneto-optical tuning of ferromagnetic resonance in silicon-doped yttrium iron garnet
Magneto-optical tuning of ferromagnetic resonance in silicon-doped yttrium iron garnet Open
This report is on experiments and theory on the process of optically stimulated electron population density redistribution in Si-substituted yttrium-iron garnet single crystals at 77 K. It was determined that a photo-induced uniaxial aniso…
View article: Novel frequency selective B<sub>1</sub> focusing passive lenz resonators for substantial MRI signal-to-noise ratio amplification
Novel frequency selective B<sub>1</sub> focusing passive lenz resonators for substantial MRI signal-to-noise ratio amplification Open
Objective. The need for increased sensitivity in magnetic resonance imaging (MRI) is crucial for its advancement as an imaging modality. The development of passive Lenz Resonators (LRs) for effective RF magnetic field (B 1 ) focusing will …
View article: Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges
Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges Open
Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine in full concordance with personalized medicine. A wide…
View article: Cucurbit[6]uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0T
Cucurbit[6]uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0T Open
The front cover artwork is provided by Prof. Mitchell S. Albert's group at Lakehead University. The image shows the hyperpolarized chemical exchange saturation transfer (HyperCEST) effect in cucurbit[6]uril molecular biosensors within a bl…
View article: Front Cover: Cucurbit[6]uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0T (ChemPhysChem 23/2023)
Front Cover: Cucurbit[6]uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0T (ChemPhysChem 23/2023) Open
The Front Cover illustrates the Hyperpolarized chemical exchange transfer (HyperCEST) of hyperpolarized 129Xe and cucurbit[6]uril molecules in a blood vessel. The polarized 129Xe gets depolarized inside the cucurbit[6]uril using a depolari…
View article: Cucurbit[6]uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0T
Cucurbit[6]uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0T Open
Molecular imaging is the future of personalized medicine; however, it requires effective contrast agents. Hyperpolarized chemical exchange saturation transfer (HyperCEST) can boost the signal of Hyperpolarized 129 Xe MRI and render it a mo…
View article: Revealing a Third Dissolved-Phase Xenon-129 Resonance in Blood Caused by Hemoglobin Glycation
Revealing a Third Dissolved-Phase Xenon-129 Resonance in Blood Caused by Hemoglobin Glycation Open
Hyperpolarized (HP) xenon-129 (129Xe), when dissolved in blood, has two NMR resonances: one in red blood cells (RBC) and one in plasma. The impact of numerous blood components on these resonances, however, has not yet been investigated. Th…
View article: Postacute COVID-19 Syndrome: <sup>129</sup>Xe MRI Ventilation Defects and Respiratory Outcomes 1 Year Later
Postacute COVID-19 Syndrome: <sup>129</sup>Xe MRI Ventilation Defects and Respiratory Outcomes 1 Year Later Open
Background In individuals with postacute COVID-19 syndrome (PACS) and normal pulmonary function, xenon 129 (129Xe) MRI ventilation defects, abnormal quality-of-life scores, and exercise limitation were reported 3 months after infection; th…
View article: Longitudinal follow-up of postacute COVID-19 syndrome: DL<sub>CO</sub>, quality-of-life and MRI pulmonary gas-exchange abnormalities
Longitudinal follow-up of postacute COVID-19 syndrome: DL<sub>CO</sub>, quality-of-life and MRI pulmonary gas-exchange abnormalities Open
129 Xe MRI red blood cell to alveolar tissue plasma ratio (RBC:TP) abnormalities have been observed in ever-hospitalised and never-hospitalised people with postacute COVID-19 syndrome (PACS). But, it is not known if such abnormalities reso…
View article: Persistent <sup>129</sup>Xe MRI Pulmonary and CT Vascular Abnormalities in Symptomatic Individuals with Post-acute COVID-19 Syndrome
Persistent <sup>129</sup>Xe MRI Pulmonary and CT Vascular Abnormalities in Symptomatic Individuals with Post-acute COVID-19 Syndrome Open
Xenon 129 (129Xe) MRI measurements were lower in participants previously infected with COVID-19 who were admitted to in-patient treatment in hospital with post-acute COVID-19 syndrome, 34 weeks ± 25 after infection compared to controls. Th…
View article: <sup>129</sup>Xe MRI ventilation defects in ever-hospitalised and never-hospitalised people with post-acute COVID-19 syndrome
<sup>129</sup>Xe MRI ventilation defects in ever-hospitalised and never-hospitalised people with post-acute COVID-19 syndrome Open
Background Patients often report persistent symptoms beyond the acute infectious phase of COVID-19. Hyperpolarised 129 Xe MRI provides a way to directly measure airway functional abnormalities; the clinical relevance of 129 Xe MRI ventilat…
View article: Hyperpolarized <scp><sup>129</sup>Xe</scp> imaging of the brain: Achievements and future challenges
Hyperpolarized <span><sup>129</sup>Xe</span> imaging of the brain: Achievements and future challenges Open
Hyperpolarized (HP) xenon‐129 ( 129 Xe) brain MRI is a promising imaging modality currently under extensive development. HP 129 Xe is nontoxic, capable of dissolving in pulmonary blood, and is extremely sensitive to the local environment. …
View article: Hyperpolarized <sup>129</sup>Xe multi‐slice imaging of the human brain using a 3D gradient echo pulse sequence
Hyperpolarized <sup>129</sup>Xe multi‐slice imaging of the human brain using a 3D gradient echo pulse sequence Open
Purpose To demonstrate the possibility of performing multi‐slice in‐vivo human brain MRI using hyperpolarized (HP) xenon‐129 ( 129 Xe) in two different orientations and to calculate the signal‐to‐noise ratio (SNR). Methods Two healthy fema…
View article: Cyclodextrin-Based Contrast Agents for Medical Imaging
Cyclodextrin-Based Contrast Agents for Medical Imaging Open
Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides consisting of multiple glucose subunits. CDs are widely used in host–guest chemistry and biochemistry due to their structural advantages, biocompatibility, and ability to …
View article: Decacationic Pillar[5]arene: A New Scaffold for the Development of <sup>129</sup>Xe MRI Imaging Agents
Decacationic Pillar[5]arene: A New Scaffold for the Development of <sup>129</sup>Xe MRI Imaging Agents Open
A decacationic water-soluble pillar[5]arene possessing a nonsolvated hydrophobic core has been designed and synthesized. This supramolecular host is capable of binding xenon, as evidenced by hyperCEST depletion experiments. Fluorescence-ba…
View article: Hyperpolarized 129Xe Time-of-Flight MR Imaging of Perfusion and Brain Function
Hyperpolarized 129Xe Time-of-Flight MR Imaging of Perfusion and Brain Function Open
Perfusion measurements can provide vital information about the homeostasis of an organ and can therefore be used as biomarkers to diagnose a variety of cardiovascular, renal, and neurological diseases. Currently, the most common techniques…
View article: Evaluation of fluorine‐19 magnetic resonance imaging of the lungs using octafluorocyclobutane in a rat model
Evaluation of fluorine‐19 magnetic resonance imaging of the lungs using octafluorocyclobutane in a rat model Open
Purpose To test octafluorocyclobutane (OFCB) as an inhalation contrast agent for fluorine‐19 MRI of the lung, and to compare the image quality of OFCB scans with perfluoropropane (PFP) scans Theory and Methods After normalizing for the num…
View article: Molecular Imaging of Fluorinated Probes for Tau Protein and Amyloid-β Detection
Molecular Imaging of Fluorinated Probes for Tau Protein and Amyloid-β Detection Open
Alzheimer’s disease (AD) is the most common form of dementia and results in progressive neurodegeneration. The incidence rate of AD is increasing, creating a major public health issue. AD is characterized by neurofibrillary tangles (NFTs) …
View article: Inhaled Xenon Washout as a Biomarker of Alzheimer’s Disease
Inhaled Xenon Washout as a Biomarker of Alzheimer’s Disease Open
Biomarkers have the potential to aid in the study of Alzheimer’s disease (AD); unfortunately, AD biomarker values often have a high degree of overlap between healthy and AD individuals. This study investigates the potential utility of a se…
View article: Inhaled Xenon Washout as a Biomarker of Alzheimer&rsquo;s Disease
Inhaled Xenon Washout as a Biomarker of Alzheimer’s Disease Open
Biomarkers have the potential to aid in the study of Alzheimer’s disease (AD); unfortunately, AD biomarker values often have a high degree of overlap between healthy and AD individuals. This study investigates the potential utility o…
View article: Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents
Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents Open
Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of…
View article: Recent Progress in Alzheimer’s Disease Research, Part 3: Diagnosis and Treatment
Recent Progress in Alzheimer’s Disease Research, Part 3: Diagnosis and Treatment Open
The field of Alzheimer’s disease (AD) research has grown exponentially over the past few decades, especially since the isolation and identification of amyloid-β from postmortem examination of the brains of AD patients. Recently, the Journa…
View article: In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor
In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor Open
The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished b…
View article: HyperCEST detection of cucurbit[6]uril in whole blood using an ultrashort saturation Pre‐pulse train
HyperCEST detection of cucurbit[6]uril in whole blood using an ultrashort saturation Pre‐pulse train Open
Xenon based biosensors have the potential to detect and localize biomarkers associated with a wide variety of diseases. The development and nuclear magnetic resonance (NMR) characterization of cage molecules which encapsulate hyperpolarize…