Max B. Mitchell
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View article: Increased Endothelin-1 Is Associated With Morbidity in Single Ventricle Heart Disease in Children Undergoing Fontan Palliation
Increased Endothelin-1 Is Associated With Morbidity in Single Ventricle Heart Disease in Children Undergoing Fontan Palliation Open
SVHD children with higher peri-operative ET1 experience more post-stage 3 morbidity. Failure to suppress ET1 may be a modifiable risk factor for intolerance of SVHD palliation.
View article: Perturbations of tryptophan catabolism via the kynurenine pathway are associated with stage 2 postoperative outcomes in single ventricle heart disease
Perturbations of tryptophan catabolism via the kynurenine pathway are associated with stage 2 postoperative outcomes in single ventricle heart disease Open
Preliminary evidence suggests perturbations of the kynurenine pathway (KP) of tryptophan metabolism in infants with single ventricle heart disease (SVHD). In 72 infants with SVHD undergoing stage 2 palliation (S2P) and 41 controls, we quan…
View article: Donor great vessel free arterial grafts for complex reconstruction during pediatric heart transplantation
Donor great vessel free arterial grafts for complex reconstruction during pediatric heart transplantation Open
Donor free arterial grafts for concomitant great vessel reconstruction during heart transplant in small, single-ventricle patients reduces warm ischemia time, simplifies technical demands, and preserves growth potential.
View article: Unraveling Autism: Using Brain Organoids to Investigate Sex Differences in Brain Development
Unraveling Autism: Using Brain Organoids to Investigate Sex Differences in Brain Development Open
View article: Arginine-NO metabolites are associated with morbidity in single ventricle infants undergoing stage 2 palliation
Arginine-NO metabolites are associated with morbidity in single ventricle infants undergoing stage 2 palliation Open
View article: The proteomic fingerprint in infants with single ventricle heart disease in the interstage period: evidence of chronic inflammation and widespread activation of biological networks
The proteomic fingerprint in infants with single ventricle heart disease in the interstage period: evidence of chronic inflammation and widespread activation of biological networks Open
Introduction Children with single ventricle heart disease (SVHD) experience significant morbidity across systems and time, with 70% of patients experiencing acute kidney injury, 33% neurodevelopmental impairment, 14% growth failure, and 5.…
View article: 4D‐Flow MRI intracardiac flow analysis considering different subtypes of pulmonary hypertension
4D‐Flow MRI intracardiac flow analysis considering different subtypes of pulmonary hypertension Open
Intracardiac flow hemodynamic patterns have been considered to be an early sign of diastolic dysfunction. In this study we investigated right ventricular (RV) diastolic dysfunction between patients with pulmonary arterial hypertension (PAH…
View article: Hemi-Fontan and bidirectional Glenn operations result in flow-mediated viscous energy loss at the time of stage II palliation
Hemi-Fontan and bidirectional Glenn operations result in flow-mediated viscous energy loss at the time of stage II palliation Open
View article: Circulating biomarkers of extracellular matrix dysregulation are associated with adverse post-stage 2 outcomes in infants with single ventricle heart disease
Circulating biomarkers of extracellular matrix dysregulation are associated with adverse post-stage 2 outcomes in infants with single ventricle heart disease Open
Children with single ventricle heart disease (SVHD) experience morbidity due to inadequate pulmonary blood flow. Using proteomic screening, our group previously identified members of the matrix metalloproteinase (MMP), tissue inhibitor of …
View article: Computed tomography-derived normative values and z-scores of right ventricular outflow tract structures in the pediatric population
Computed tomography-derived normative values and z-scores of right ventricular outflow tract structures in the pediatric population Open
Background Recent advances in available percutaneous device technology require accurate measurements and quantification of relationships between right ventricular outflow tract (RVOT) structures in children with and without congenital hear…
View article: Myocardial strain-curve deformation patterns after Fontan operation
Myocardial strain-curve deformation patterns after Fontan operation Open
Myocardial deformation analysis by cardiac MRI (CMR) yielding global circumferential and longitudinal strain (GCS and GLS) is an increasingly utilized method to accurately quantify systolic function and predict clinical events in patients …
View article: The Inner Complexities of Multimodal Medical Data: Bitmap-Based 3D Printing for Surgical Planning Using Dynamic Physiology
The Inner Complexities of Multimodal Medical Data: Bitmap-Based 3D Printing for Surgical Planning Using Dynamic Physiology Open
Motivated by the need to develop more informative and data-rich patient-specific presurgical planning models, we present a high-resolution method that enables the tangible replication of multimodal medical data. By leveraging voxel-level c…
View article: Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways
Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways Open
The circulating metabolome of interstage SVHD infants differs significantly from controls and is further disrupted after Stage 2. Several metabolites showed trends toward association with adverse outcomes. Metabolic dysregulation may be an…
View article: Pediatric Heart Transplant Waiting List Times in the US During the COVID-19 Pandemic
Pediatric Heart Transplant Waiting List Times in the US During the COVID-19 Pandemic Open
This cohort study investigates the association between the COVID-19 pandemic and waiting list times among pediatric heart transplant recipients in the US.
View article: Frozen elephant trunk aortic reconstruction in a patient with Loeys-Dietz syndrome
Frozen elephant trunk aortic reconstruction in a patient with Loeys-Dietz syndrome Open
Central MessageLDS is a rare connective tissue disorder with aggressive aortic disease involvement. We present frozen elephant trunk treatment of a transverse arch aneurysm in a pediatric patient with LDS. LDS is a rare connective tissue d…
View article: Table of Contents
Table of Contents Open
View article: Open Chest Duration Following Congenital Cardiac Surgery Increases Risk for Surgical Site Infection
Open Chest Duration Following Congenital Cardiac Surgery Increases Risk for Surgical Site Infection Open
OBJECTIVES: Surgical site infections (SSI) following congenital heart surgery (CHS) remain a significant source of morbidity. Delayed sternal closure (DSC) is often required to minimize the potential for hemodynamic instability. The purpos…
View article: Reply from authors: The unbearable weight of shape and flow quality
Reply from authors: The unbearable weight of shape and flow quality Open
View article: Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension
Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension Open
Background Electromechanical dyssynchrony is a well described comorbidity in pulmonary arterial hypertension (PAH). ECG‐derived measurements reflective of diastolic dysfunction and electromechanical imaging markers are yet to be investigat…
View article: Short‐Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4‐Dimensional–Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension
Short‐Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4‐Dimensional–Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension Open
Background Pulmonary arterial hypertension (PAH) manifests with progressive right ventricular (RV) dysfunction, which eventually impairs the left ventricular function. We hypothesized that 4‐dimensional–flow magnetic resonance imaging can …
View article: COVID-19 Testing, Surgical Prioritization, and Reactivation in a Congenital Cardiac Surgery Program
COVID-19 Testing, Surgical Prioritization, and Reactivation in a Congenital Cardiac Surgery Program Open
View article: Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls
Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls Open
View article: Native Aortic Root Thrombosis After Norwood Palliation for Hypoplastic Left Heart Syndrome
Native Aortic Root Thrombosis After Norwood Palliation for Hypoplastic Left Heart Syndrome Open
View article: Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study
Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study Open
View article: Reply to Commentary: Can't flow down: More 4-dimensional flow magnetic resonance imaging studies are needed in congenital heart disease
Reply to Commentary: Can't flow down: More 4-dimensional flow magnetic resonance imaging studies are needed in congenital heart disease Open
View article: Commentary: In vortices veritas—quantitative approach
Commentary: In vortices veritas—quantitative approach Open
View article: Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study)
Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study) Open
View article: Novel application of 4D flow magnetic resonance imaging in a neonatal post-operative aortic dissection
Novel application of 4D flow magnetic resonance imaging in a neonatal post-operative aortic dissection Open
View article: Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study
Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study Open
The Fontan circulation is characterized as a nonpulsatile flow propagation without a pressure-generating ventricle. However, flow through the Fontan circulation still exhibits oscillatory waves as a result of pressure changes generated by …
View article: Novel measures of left ventricular electromechanical discoordination predict clinical outcomes in children with pulmonary arterial hypertension
Novel measures of left ventricular electromechanical discoordination predict clinical outcomes in children with pulmonary arterial hypertension Open
Adverse ventricle-ventricle interaction and resultant left ventricular (LV) dysfunction are a recognized pathophysiological component of disease progression in pulmonary arterial hypertension (PAH) and can be associated with electrical and…