Michael Mitchell
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View article: Getting to Know Me: Enhancing Person-Centred Care in a Specialist Geriatric Acute Care Setting
Getting to Know Me: Enhancing Person-Centred Care in a Specialist Geriatric Acute Care Setting Open
Background Person-centred care has been shown to reduce agitation, delirium, psychotropic use, and falls (Chenoweth et al., 2024). This project aimed to improve care for patients with cognitive impairment or communication difficulties by r…
View article: The Ongoing Decline in Activity of Comet 103P/Hartley 2
The Ongoing Decline in Activity of Comet 103P/Hartley 2 Open
We report photometric observations of Comet 103P/Hartley 2 during its 2023 apparition. Our campaign, conducted from August through December 2023, combined data from a global network of citizen astronomers coordinated by Unistellar and the …
View article: P-600 Loss of nucleoporin NUP210L and chromatin protein BAF-L together, but not separately cause male infertility in the mouse revealing their redundant roles in nuclear integrity
P-600 Loss of nucleoporin NUP210L and chromatin protein BAF-L together, but not separately cause male infertility in the mouse revealing their redundant roles in nuclear integrity Open
Study question Could colocalised spermatid-specific genes Banf2 and Nup210l, whose individual loss has no effect on male fertility, have redundant functions at the caudal nuclear envelope? Summary answer Banf2 and Nup210l are required toge…
View article: GRANDMA Observations of SN 2023wrk, a Luminous Type Ia Supernova with Significant Unburned Carbon in the Outer Ejecta
GRANDMA Observations of SN 2023wrk, a Luminous Type Ia Supernova with Significant Unburned Carbon in the Outer Ejecta Open
First detected on 2023 November 4 by the Gravitational-wave Optical Transient Observer, SN 2023wrk is a Type Ia Supernova at 40 Mpc, with significant unburned carbon in the outer ejecta. In this note, we present photometric and spectroscop…
View article: Nucleoporin NUP210L and BAF-paralogue BAF-L together ensure microtubule organization and nuclear integrity in spermatids
Nucleoporin NUP210L and BAF-paralogue BAF-L together ensure microtubule organization and nuclear integrity in spermatids Open
During spermiogenesis, haploid round spermatids differentiate into spermatozoa. This involves nuclear elongation, chromatin compaction, cytoplasm reduction, and formation of the acrosome and the flagellum. These events are orchestrated by …
View article: Spermatozoa in mice lacking the nucleoporin <scp>NUP210L</scp> show defects in head shape and motility but not in nuclear compaction or histone replacement
Spermatozoa in mice lacking the nucleoporin <span>NUP210L</span> show defects in head shape and motility but not in nuclear compaction or histone replacement Open
Biallelic loss‐of‐function mutation of NUP210L , encoding a testis‐specific nucleoporin, has been reported in an infertile man whose spermatozoa show uncondensed heads and histone retention. Mice with a homozygous transgene intronic insert…
View article: Photometry of Type II Supernova SN 2023ixf with a Worldwide Citizen Science Network
Photometry of Type II Supernova SN 2023ixf with a Worldwide Citizen Science Network Open
We present highly sampled photometry of the supernova (SN) 2023ixf, a Type II SN in M101, beginning 2 days before its first known detection. To gather these data, we enlisted the global Unistellar Network of citizen scientists. These 252 o…
View article: Legal Challenges and Public Procurement in Construction in Northern Ireland
Legal Challenges and Public Procurement in Construction in Northern Ireland Open
Public procurement in the construction sector has been an historic problem in Northern Ireland (NI), to the extent that a public inquiry was held on the matter, including investigating why legal challenge are prevalent, and its findings re…
View article: 114. Prospective Trial of Passive Diversion Device to Reduce Blood Culture Contamination
114. Prospective Trial of Passive Diversion Device to Reduce Blood Culture Contamination Open
Background Blood culture contaminants can lead to inappropriate antibiotic use, prolonged length of stay, and additional hospital costs. Several devices have been developed to reduce the risk of blood culture contamination by diverting a p…
View article: Peripherally Inserted Central Catheter-Associated <i>Nocardia nova</i> Endocarditis in a Patient Receiving Intravenous Antibiotics for Chronic Lyme Disease
Peripherally Inserted Central Catheter-Associated <i>Nocardia nova</i> Endocarditis in a Patient Receiving Intravenous Antibiotics for Chronic Lyme Disease Open
Long-term antibiotics are not effective for the therapy of patients with persistent symptoms and a history of Lyme disease. However, some clinicians still prescribe these therapies. We present a case of peripherally inserted central cathet…
View article: Sleep and Function in Patients with Multiple Sclerosis
Sleep and Function in Patients with Multiple Sclerosis Open
Introduction: Fatigue is a core symptom of Multiple Sclerosis (MS) and impairs function and quality of life in this patient population. Studies show that sleep-disordered breathing is also common in persons with MS and may exacerbate fatig…
View article: RE: Preventability of hospital onset bacterermia and fungemia: A pilot study of potential healthcare-associated infection outcome measure, by Dantes et al (2019)
RE: Preventability of hospital onset bacterermia and fungemia: A pilot study of potential healthcare-associated infection outcome measure, by Dantes et al (2019) Open
We read with great interest the article by Dantes et al on the preventability of hospital-onset bacteremias (HOBs) and the use of this metric as a quality outcome measure. In 2017, we also reported a retrospective analysis of the impact of…
View article: Radiographic Analysis of Glenoid Morphology after Arthroscopic Latarjet vs Distal Tibial Allograft in the Treatment of Anterior Shoulder Instability
Radiographic Analysis of Glenoid Morphology after Arthroscopic Latarjet vs Distal Tibial Allograft in the Treatment of Anterior Shoulder Instability Open
Objectives: The Latarjet procedure for autograft transposition of coracoid to the anterior rim of the glenoid remains the most common procedure for reconstruction of the glenoid after shoulder instability. The anatomic glenoid reconstructi…
View article: LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist
LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist Open
During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. After fertilisation, this process is reversed in the oocyte to form the …
View article: Homozygous deletion of SUN5 in three men with decapitated spermatozoa
Homozygous deletion of SUN5 in three men with decapitated spermatozoa Open
A recent study of 17 men with decapitated spermatozoa found that 8 carried two rare SUN5 alleles, and concluded that loss of SUN5 function causes the acephalic spermatozoa syndrome. Consistent with this, the SUN5 protein localises to the h…
View article: Recrudescence of Plasmodium falciparum in a Primigravida After Nearly 3 Years of Latency
Recrudescence of Plasmodium falciparum in a Primigravida After Nearly 3 Years of Latency Open
We present a case of a primigravid woman who presented with Plasmodium falciparum nearly 3 years after she last visited a malaria-endemic region. We review the literature to identify case reports of recrudescent P. falciparum malaria durin…
View article: Single gene defects leading to sperm quantitative anomalies
Single gene defects leading to sperm quantitative anomalies Open
Azoospermia, defined by the absence of sperm in the ejaculate, is estimated to affect up to 1% of men in the general population. Assisted reproductive technologies have revolutionized the treatment of infertility, and some azoospermic men,…
View article: Genetic abnormalities leading to qualitative defects of sperm morphology or function
Genetic abnormalities leading to qualitative defects of sperm morphology or function Open
Infertility, defined by the inability of conceiving a child after 1 year is estimated to concern approximately 50 million couples worldwide. As the male gamete is readily accessible and can be studied by a simple spermogram it is easier to…
View article: Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction
Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction Open
Replacing the Y chromosome The mammalian Y chromosome encodes a specialized set of genes that are essential for male viability and fertility. In particular, the sex-determining region Y (SRY) protein is necessary to initiate male sex deter…