Stéphane Cook
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View article: AI-Automated Risk Operative Stratification for Severe Aortic Stenosis: A Proof-of-Concept Study
AI-Automated Risk Operative Stratification for Severe Aortic Stenosis: A Proof-of-Concept Study Open
Background: Accurate operative risk stratification is essential for treatment selection in severe aortic stenosis. We developed an automated workflow using large language models (LLMs) to replicate Heart Team risk assessment. Methods: We r…
Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging Open
Aging is a predominant risk factor for heart disease. Aging heart reveals low-grade chronic inflammation, cell apoptosis, cardiac fibrosis, and increased vulnerability to ischemic injury. The underlying molecular mechanisms responsible for…
View article: Diagnostic delays and cardiovascular mortality in left circumflex culprit ST-segment elevation myocardial infarction: a 16-year experience
Diagnostic delays and cardiovascular mortality in left circumflex culprit ST-segment elevation myocardial infarction: a 16-year experience Open
LCx culprit lesions in our fast-track STEMI network showed diagnostic delays, larger enzymatic infarcts despite preserved LVEF, and increased early CV mortality. This contrasts with favorable long-term outcomes among survivors at 30 days, …
View article: Artificial Intelligence and Advanced Digital Health for Hypertension: Evolving Tools for Precision Cardiovascular Care
Artificial Intelligence and Advanced Digital Health for Hypertension: Evolving Tools for Precision Cardiovascular Care Open
Background: Hypertension remains the leading global risk factor for cardiovascular morbidity and mortality, with suboptimal control rates despite guideline-directed therapies. Digital health and artificial intelligence (AI) technologies of…
View article: Disparities in ST-elevation myocardial infarction diagnosis and management among patients with mental health conditions
Disparities in ST-elevation myocardial infarction diagnosis and management among patients with mental health conditions Open
Aims Patients with mental health conditions (MHCs) experience delayed diagnosis and management. We aimed to assess whether these patients had longer treatment delays and poorer outcomes despite a dedicated ST-elevation myocardial infarctio…
View article: Mobile Health Applications for Secondary Prevention After Myocardial Infarction or PCI: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Mobile Health Applications for Secondary Prevention After Myocardial Infarction or PCI: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Background: Mobile health applications have emerged as a novel tool to support secondary prevention after myocardial infarction (MI) or percutaneous coronary intervention (PCI). However, the impact of app-based interventions on clinically …
Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging Open
Aging is a predominant risk factor for heart disease. Aging heart reveals low-grade chronic inflammation, cell apoptosis, cardiac fibrosis, and increased vulnerability to ischemic injury. The underlying molecular mechanisms responsible for…
View article: Improving large language models accuracy for aortic stenosis treatment via Heart Team simulation: a prompt design analysis
Improving large language models accuracy for aortic stenosis treatment via Heart Team simulation: a prompt design analysis Open
Aims Large language models (LLMs) have shown potential in clinical decision support, but the influence of prompt design on their performance, particularly in complex cardiology decision-making, is not well understood. Methods and results W…
View article: Diagnostic Accuracy of Angiography‐Derived Murray Law‐Based Quantitative Flow Ratio (μQFR) Versus Pressure‐Derived Fractional Flow Reserve (FFR) in Moderate to Severe Calcified Coronary Lesions—The DIAMOND Study
Diagnostic Accuracy of Angiography‐Derived Murray Law‐Based Quantitative Flow Ratio (μQFR) Versus Pressure‐Derived Fractional Flow Reserve (FFR) in Moderate to Severe Calcified Coronary Lesions—The DIAMOND Study Open
Background Murray law‐based Quantitative Flow Ratio (μQFR) is an innovative AI‐driven method for evaluating coronary lesions using contrast flow velocity estimates. Unlike traditional approaches, μQFR does not require pressure wires or hyp…
Case Report: Late coronary complication of Kawasaki disease Open
Kawasaki disease, a common cause of acquired heart disease in children, can lead to long-term cardiovascular complications such as coronary aneurysms and stenosis. This case describes a 17-year-old male with a past medical history of Kawas…
Durable versus biodegradable polymer drug-eluting stents in all-comers Open
Background Drug-eluting stents (DESs) have become the gold standard of coronary angioplasty since their inception in 2002. Biodegradable polymer DESs (BP-DESs) have been postulated to be superior to durable polymer DESs (DP-DESs) due to th…
View article: Role of Routine Electrophysiological Study Performed During Transcatheter Aortic Valve Replacement to Predict AV Block
Role of Routine Electrophysiological Study Performed During Transcatheter Aortic Valve Replacement to Predict AV Block Open
Background Periprocedural electrophysiological (EP) testing may be useful to predict high degree atrioventricular block (HAVB) risk in patients undergoing transcatheter aortic valve replacement (TAVR). Objective To determine whether pre‐ a…
Call for a consensual definition of dyslipidemia in coronary angiography trials Open
Dyslipidemia is extensively analyzed in clinical trials investigating its role as a risk factor for coronary artery disease (CAD). However, its definition varies vastly among studies, leading to different attributions to the variable dysli…
View article: An approach to fluoroless radiofrequency atrial fibrillation ablation
An approach to fluoroless radiofrequency atrial fibrillation ablation Open
Atrial fibrillation is the most prevalent arrhythmia with a lifetime risk of nearly 30%. It can be associated with reduced quality of life and complications such as heart failure and stroke. Pulmonary vein isolation (PVI) is the most effec…
Sex differences in ST-segment elevation myocardial infarction patients treated by primary percutaneous intervention Open
Introduction The impact of sex on coronary artery disease prognosis is debated. It has been postulated that women receive less prompt treatment compared with men, potentially adversely affecting their prognosis by significantly increasing …
High HDL‐Cholesterol Levels Are Associated With Lower Risk of Acute Coronary Syndromes in Coronary Artery Disease Open
Background: The inverse association between HDL‐cholesterol (HDL‐C) levels and the risk of cardiovascular diseases is evident. Hypothesis: Our hypothesis was that higher levels of HDL‐C predisposed patients with coronary artery disease (CA…
View article: Ten-year clinical outcomes of everolimus- and biolimus-eluting coronary stents vs. everolimus-eluting bioresorbable vascular scaffolds—insights from the EVERBIO-2 trial
Ten-year clinical outcomes of everolimus- and biolimus-eluting coronary stents vs. everolimus-eluting bioresorbable vascular scaffolds—insights from the EVERBIO-2 trial Open
Background Bioresorbable vascular scaffolds (BVSs) have been developed as a potential solution to mitigate late complications associated with drug-eluting metallic stents (DESs) in percutaneous coronary intervention for coronary artery dis…
Experience with a novel high frequency optical coherence tomography device for intracoronary imaging: a case series Open
Introduction Intravascular imaging, especially optical coherence tomography (OCT), has significantly improved percutaneous coronary intervention (PCI), yet its routine clinical application faces challenges. This case series introduces the …
View article: Clinical outcomes with thin versus thick strut polymer-free biolimus-coated stents at 3 years
Clinical outcomes with thin versus thick strut polymer-free biolimus-coated stents at 3 years Open
Background For high bleeding-risk patients (HBR) undergoing percutaneous coronary intervention (PCI), the LEADERS FREE (LF) and LEADERS FREE II (LF II) trials established the safety and efficacy of a stainless steel polymer-free biolimus-c…
View article: Impact of cardiac health status on bone marrow cell secretome and myocardial repair
Impact of cardiac health status on bone marrow cell secretome and myocardial repair Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): University of Fribourg Graduate assistant Background Restoring the damaged myocardium remains a significant clinical challenge. Administration…
Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging Open
Aging is a predominant risk factor for heart disease. Aging heart reveals low-grade chronic inflammation, cell apoptosis, cardiac fibrosis, and increased vulnerability to ischemic injury. The underlying molecular mechanisms responsible for…