Mitchell Gravely
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View article: Evaluation of the Cancer-Preventive Effect of Resveratrol-Loaded Nanoparticles on the Formation and Growth of In Vitro Lung Tumor Spheroids
Evaluation of the Cancer-Preventive Effect of Resveratrol-Loaded Nanoparticles on the Formation and Growth of In Vitro Lung Tumor Spheroids Open
Background: Resveratrol (RSV) is a natural polyphenol that offers antioxidant, anti-inflammatory, and chemopreventive benefits. This project determined the ability of RSV-loaded nanoparticles (NP) to inhibit the growth of lung tumor sphero…
View article: Aggregation Reduces Subcellular Localization and Cytotoxicity of Single-Walled Carbon Nanotubes
Aggregation Reduces Subcellular Localization and Cytotoxicity of Single-Walled Carbon Nanotubes Open
The non-covalent biomolecular functionalization of fluorescent single-walled carbon nanotubes (SWCNTs) has resulted in numerous in vitro and in vivo sensing and imaging applications due to many desirable optical properties. In these applic…
View article: Hyperspectral Counting of Multiplexed Nanoparticle Emitters in Single Cells and Organelles
Hyperspectral Counting of Multiplexed Nanoparticle Emitters in Single Cells and Organelles Open
Nanomaterials are the subject of a range of biomedical, commercial, and environmental investigations involving measurements in living cells and tissues. Accurate quantification of nanomaterials, at the tissue, cell, and organelle levels, i…
View article: A Spin-Coated Hydrogel Platform Enables Accurate Investigation of Immobilized Individual Single-Walled Carbon Nanotubes
A Spin-Coated Hydrogel Platform Enables Accurate Investigation of Immobilized Individual Single-Walled Carbon Nanotubes Open
Single-walled carbon nanotubes (SWCNTs) have been used in a variety of sensing and imaging applications over the past few years due to their unique optical properties. In the solution phase, SWCNTs are employed as near-infrared (NIR) fluor…
View article: Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells
Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells Open
Intracellular vesicle trafficking involves a complex series of biological pathways used to sort, recycle, and degrade extracellular components, including engineered nanomaterials (ENMs) which gain cellular entry via active endocytic proces…
View article: A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress
A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress Open
In an effort to facilitate personalized medical approaches, the continuous and noninvasive monitoring of biochemical information using wearable technologies can enable a detailed understanding of an individual's physiology. Reactive oxygen…
View article: PROBING INTERACTIONS OF SINGLE-WALLED CARBON NANOTUBES AT THE NANO-BIO INTERFACE
PROBING INTERACTIONS OF SINGLE-WALLED CARBON NANOTUBES AT THE NANO-BIO INTERFACE Open
Non-covalent hybrids of single-stranded DNA and single-walled carbon nanotubes (DNA-SWCNTs) have demonstrated applications in biomedical imaging and sensing due to their enhanced biocompatibility and photostable, environmentally-responsive…
View article: Carbon Nanotube–Liposome Complexes in Hydrogels for Controlled Drug Delivery via Near-Infrared Laser Stimulation
Carbon Nanotube–Liposome Complexes in Hydrogels for Controlled Drug Delivery via Near-Infrared Laser Stimulation Open
Externally controllable drug delivery systems are crucial for a variety of biological applications where the dosage and timing of drug delivery need to be adjusted based on disease diagnosis and progression. Here, we have developed an exte…
View article: Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells
Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells Open
Intracellular vesicle trafficking involves a complex series of biological pathways used to sort, recycle, and degrade extracellular components, including engineered nanomaterials which gain cellular entry via active endocytic processes. A …
View article: Biomolecular Functionalization of a Nanomaterial To Control Stability and Retention within Live Cells
Biomolecular Functionalization of a Nanomaterial To Control Stability and Retention within Live Cells Open
Noncovalent hybrids of single-stranded DNA and single-walled carbon nanotubes (SWCNTs) have demonstrated applications in biomedical imaging and sensing due to their enhanced biocompatibility and photostable, environmentally responsive near…
View article: Oligonucleotide Length Determines Intracellular Stability of DNA-Wrapped Carbon Nanotubes
Oligonucleotide Length Determines Intracellular Stability of DNA-Wrapped Carbon Nanotubes Open
Non-covalent hybrids of single-stranded DNA and single-walled carbon nanotubes (SWCNTs) have demonstrated applications in biomedical imaging and sensing due to their enhanced biocompatibility and photostable, environmentally-responsive nea…
View article: DNA Sequence Mediates Apparent Length Distribution in Single-Walled Carbon Nanotubes
DNA Sequence Mediates Apparent Length Distribution in Single-Walled Carbon Nanotubes Open
Single-walled carbon nanotubes (SWCNTs) functionalized with short single-stranded DNA have been extensively studied within the last decade for biomedical applications due to the high dispersion efficiency and intrinsic biocompatibility of …