Mitchell J. Waldran
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View article: Unraveling <i>Streptococcus pyogenes</i> Carriage: Genomic and Transcriptomic Insights from Acute and Post-Treatment Phases
Unraveling <i>Streptococcus pyogenes</i> Carriage: Genomic and Transcriptomic Insights from Acute and Post-Treatment Phases Open
The carrier state of Streptococcus pyogenes (Group A Streptococcus, GAS), is defined by the presence of the organism without symptoms or an immune response. Carriage poses challenges for clinical management and contributes to transmission …
View article: Conventional and antibody-enhanced DENV infection of human macrophages induces differential immunotranscriptomic profiles
Conventional and antibody-enhanced DENV infection of human macrophages induces differential immunotranscriptomic profiles Open
Dengue virus (DENV) is a mosquito-borne flavivirus which coexists as four genetically and immunologically distinct serotypes (DENV-1 to -4). In secondary heterologous DENV infection, pre-existing immunity is believed to contribute to sever…
View article: Dengue Virus Structural Proteins Are Expressed on the Surface of DENV-Infected Cells and Are a Target for Antibody-Dependent Cellular Phagocytosis
Dengue Virus Structural Proteins Are Expressed on the Surface of DENV-Infected Cells and Are a Target for Antibody-Dependent Cellular Phagocytosis Open
Background Dengue virus (DENV) is an arboviral pathogen found in >100 countries and a source of significant morbidity and mortality. While the mechanisms underpinning the pathophysiology of severe Dengue are incompletely understood, it …
View article: DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection
DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection Open
Dengue represents a growing public health burden worldwide, accounting for approximately 100 million symptomatic cases and tens of thousands of fatalities yearly. Prior infection with one serotype of dengue virus (DENV) is the greatest kno…
View article: DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection
DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection Open
Dengue represents a growing public health burden worldwide, accounting for approximately 100 million symptomatic cases and tens of thousands of fatalities yearly. Prior infection with one serotype of dengue virus (DENV) is the greatest kno…
View article: Soluble NS1 antagonizes IgG- and IgA-mediated monocytic phagocytosis of DENV infected cells
Soluble NS1 antagonizes IgG- and IgA-mediated monocytic phagocytosis of DENV infected cells Open
Dengue virus (DENV) is endemic in over 100 countries, infecting an estimated 400 million individuals every year. Infection with DENV raises a significant antibody response, primarily consisting of antibodies targeting viral (structural) pr…
View article: Virologic, clinical, and immunological characteristics of a dengue virus 3 human challenge model
Virologic, clinical, and immunological characteristics of a dengue virus 3 human challenge model Open
Dengue human infection models present an opportunity to explore a vaccine, antiviral, or immuno-compound’s potential for clinical benefit in a controlled setting. Herein, we report the outcome of a phase 1, open-label assessment of a DENV-…
View article: Simultaneous analysis of antigen‐specific B and T cells after SARS‐CoV‐2 infection and vaccination
Simultaneous analysis of antigen‐specific B and T cells after SARS‐CoV‐2 infection and vaccination Open
Conventional methods for quantifying and phenotyping antigen‐specific lymphocytes can rapidly deplete irreplaceable specimens. This is due to the fact that antigen‐specific T and B cells have historically been analyzed in independent assay…
View article: Evolution of inflammation and immunity in a dengue virus 1 human infection model
Evolution of inflammation and immunity in a dengue virus 1 human infection model Open
Dengue virus (DENV) infections are significant sources of morbidity and mortality throughout the tropics and subtropics. Over 400 million infections are estimated to occur every year, resulting in nearly 100 million symptomatic infections …
View article: Simultaneous analysis of antigen-specific B and T cells after SARS-CoV-2 infection and vaccination
Simultaneous analysis of antigen-specific B and T cells after SARS-CoV-2 infection and vaccination Open
Conventional methods for quantifying and phenotyping antigen-specific lymphocytes can rapidly deplete irreplaceable specimens. This is due to the fact that antigen-specific T and B cells have historically been analyzed in independent assay…