Mitchell Kuss
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View article: Therapeutic Potential of BMX-001 for Preventing Chemotherapy-Induced Peripheral Neuropathic Pain
Therapeutic Potential of BMX-001 for Preventing Chemotherapy-Induced Peripheral Neuropathic Pain Open
Background/Objectives: Chemotherapy-induced neuropathic pain (CINP) represents a critical challenge in oncology, emerging as a common and debilitating side effect of widely used chemotherapeutic agents, such as paclitaxel (PTX). Current th…
View article: Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long‐Gap Peripheral Nerve Injury
Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long‐Gap Peripheral Nerve Injury Open
Severe peripheral nerve injury (PNI) requiring nerve graft remains a clinical challenge due to limitations associated with currently available grafts. While decellularized nerve grafts (DNGs) are commonly used, their efficacy is largely re…
View article: A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions
A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions Open
Postoperative abdominal adhesions are a common and painful complication after surgery, leading to high healthcare costs and diminished quality of life. This report presents a novel bilayer hydrogel barrier featuring an inner adhesive layer…
View article: Double‐Layer Microneedle Patch Loaded with HA‐PBA‐QCT for Management of Paclitaxel‐Induced Peripheral Neuropathic Pain
Double‐Layer Microneedle Patch Loaded with HA‐PBA‐QCT for Management of Paclitaxel‐Induced Peripheral Neuropathic Pain Open
Chemotherapy‐induced neuropathic pain (CINP) is a common adverse effect of antineoplastic drugs, often leading to dose reduction, treatment delays, or cessation of chemotherapy. Chemotherapy agents, like paclitaxel (PTX), damage the somato…
View article: Multiscale embedded printing of engineered human tissue and organ equivalents
Multiscale embedded printing of engineered human tissue and organ equivalents Open
Creating tissue and organ equivalents with intricate architectures and multiscale functional feature sizes is the first step toward the reconstruction of transplantable human tissues and organs. Existing embedded ink writing approaches are…
View article: Engineering Neurotoxin-Functionalized Exosomes for Targeted Delivery to the Peripheral Nervous System
Engineering Neurotoxin-Functionalized Exosomes for Targeted Delivery to the Peripheral Nervous System Open
The administration of therapeutics to peripheral nerve tissue is challenging due to the complexities of peripheral neuroanatomy and the limitations imposed by the blood–nerve barrier (BNB). Therefore, there is a pressing need to enhance de…
View article: Embedded Bioprinting of Breast Tumor Cells and Organoids Using Low‐Concentration Collagen‐Based Bioinks
Embedded Bioprinting of Breast Tumor Cells and Organoids Using Low‐Concentration Collagen‐Based Bioinks Open
Bioinks for 3D bioprinting of tumor models should not only meet printability requirements but also accurately maintain and support phenotypes of tumor surrounding cells to recapitulate key tumor hallmarks. Collagen is a major extracellular…
View article: A Facile Strategy for the Fabrication of Cell‐Laden Porous Alginate Hydrogels based on Two‐Phase Aqueous Emulsions
A Facile Strategy for the Fabrication of Cell‐Laden Porous Alginate Hydrogels based on Two‐Phase Aqueous Emulsions Open
Porous alginate (Alg) hydrogels possess many advantages as cell carriers. However, current pore generation methods require either complex or harsh fabrication processes, toxic components, or extra purification steps, limiting the feasibili…
View article: Dynamic Alginate Hydrogel as an Antioxidative Bioink for Bioprinting
Dynamic Alginate Hydrogel as an Antioxidative Bioink for Bioprinting Open
3D bioprinting holds great potential for use in tissue engineering to treat degenerative joint disorders, such as osteoarthritis. However, there is a lack of multifunctional bioinks that can not only support cell growth and differentiation…
View article: Multifunctional Microgel-Based Cream Hydrogels for Postoperative Abdominal Adhesion Prevention
Multifunctional Microgel-Based Cream Hydrogels for Postoperative Abdominal Adhesion Prevention Open
Postoperative abdominal adhesions are a common problem after surgery and can produce serious complications. Current antiadhesive strategies focus mostly on physical barriers and are unsatisfactory and inefficient. In this study, we designe…
View article: Exercise facilitates regeneration after severe nerve transection and further modulates neural plasticity
Exercise facilitates regeneration after severe nerve transection and further modulates neural plasticity Open
Patients with severe traumatic peripheral nerve injury (PNI) always suffer from incomplete recovery and poor functional outcome. Physical exercise-based rehabilitation, as a non-invasive interventional strategy, has been widely acknowledge…
View article: A Dual‐Network Nerve Adhesive with Enhanced Adhesion Strength Promotes Transected Peripheral Nerve Repair
A Dual‐Network Nerve Adhesive with Enhanced Adhesion Strength Promotes Transected Peripheral Nerve Repair Open
Peripheral nerve transection has a high prevalence and results in functional loss of affected limbs. The current clinical treatment using suture anastomosis significantly limits nerve recovery due to severe inflammation, secondary damage, …
View article: SERS spectroscopy with machine learning to analyze human plasma derived sEVs for coronary artery disease diagnosis and prognosis
SERS spectroscopy with machine learning to analyze human plasma derived sEVs for coronary artery disease diagnosis and prognosis Open
Coronary artery disease (CAD) is one of the major cardiovascular diseases and represents the leading causes of global mortality. Developing new diagnostic and therapeutic approaches for CAD treatment are critically needed, especially for a…
View article: Three-Dimensional Printed Abdominal Imaging Windows for In Vivo Imaging of Deep-Lying Tissues
Three-Dimensional Printed Abdominal Imaging Windows for In Vivo Imaging of Deep-Lying Tissues Open
The ability to microscopically image diseased or damaged tissue throughout a longitudinal study in living mice would provide more insight into disease progression than having just a couple of time points to study. In vivo disease developme…
View article: 3D bioprinted white adipose model for <i>in vitro</i> study of cancer-associated cachexia induced adipose tissue remodeling
3D bioprinted white adipose model for <i>in vitro</i> study of cancer-associated cachexia induced adipose tissue remodeling Open
Cancer-associated cachexia (CAC) is a complex metabolic and behavioral syndrome with multiple manifestations that involve systemic inflammation, weight loss, and adipose lipolysis. It impacts the quality of life of patients and is the dire…
View article: Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets
Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets Open
3D heterogeneous and anisotropic scaffolds that approximate native heart valve tissues are indispensable for the successful construction of tissue engineered heart valves (TEHVs). In this study, novel tri‐layered and gel‐like nanofibrous s…
View article: Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions
Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions Open
Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden. Exosomes, especially those derived from mesenchymal stem cells (MSCs), are promising as potentia…
View article: Electrostatic Flocking of Insulative and Biodegradable Polymer Microfibers for Biomedical Applications (Adv. Healthcare Mater. 19/2021)
Electrostatic Flocking of Insulative and Biodegradable Polymer Microfibers for Biomedical Applications (Adv. Healthcare Mater. 19/2021) Open
Flock Fibers In article number 2100766 by Jingwei Xie and co-workers, a new technique for electrostatic flocking is used to create anisotropic structures and surfaces for regenerative medicine applications. Using this method, electrospun n…
View article: Electrostatic Flocking of Insulative and Biodegradable Polymer Microfibers for Biomedical Applications
Electrostatic Flocking of Insulative and Biodegradable Polymer Microfibers for Biomedical Applications Open
Electrostatic flocking, a textile engineering technique, uses Coulombic driving forces to propel conductive microfibers toward an adhesive‐coated substrate, leaving a forest of aligned fibers. Though an easy way to induce anisotropy along …
View article: Design and Evaluation of an In Vitro Mild Traumatic Brain Injury Modeling System Using 3D Printed Mini Impact Device on the 3D Cultured Human iPSC Derived Neural Progenitor Cells
Design and Evaluation of an In Vitro Mild Traumatic Brain Injury Modeling System Using 3D Printed Mini Impact Device on the 3D Cultured Human iPSC Derived Neural Progenitor Cells Open
Despite significant progress in understanding the disease mechanism of traumatic brain injury (TBI), promising preclinical therapeutics have seldom been translated into successful clinical outcomes, partially because the model animals have…
View article: Large‐scale synthesis of compressible and re‐expandable three‐dimensional nanofiber matrices
Large‐scale synthesis of compressible and re‐expandable three‐dimensional nanofiber matrices Open
Due to their biomimetic properties, electrospun nanofibers have shown great potential in many biomedical fields. However, traditionally‐produced nanofibers are typically two‐dimensional (2D) membranes limiting their applications. Herein, w…
View article: Age related extracellular matrix and interstitial cell phenotype in pulmonary valves
Age related extracellular matrix and interstitial cell phenotype in pulmonary valves Open
Heart valve disease is a common manifestation of cardiovascular disease and is a significant cause of cardiovascular morbidity and mortality worldwide. The pulmonary valve (PV) is of primary concern because of its involvement in common con…