Mitchell L. Wise
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View article: Quantitative Trait Loci Associated with the Tocochromanol (Vitamin E) Pathway in Barley
Quantitative Trait Loci Associated with the Tocochromanol (Vitamin E) Pathway in Barley Open
The Genome-Wide Association Studies approach was used to detect Quantitative Trait Loci associated with tocochromanol concentrations using a panel of 1,466 barley accessions. All major tocochromanol types- α-, β-, δ-, γ-tocopherol and toco…
View article: Comparative Systems Biology Reveals Allelic Variation Modulating Tocochromanol Profiles in Barley (Hordeum vulgare L.)
Comparative Systems Biology Reveals Allelic Variation Modulating Tocochromanol Profiles in Barley (Hordeum vulgare L.) Open
Tocochromanols are recognized for nutritional content, plant stress response, and seed longevity. Here we present a systems biological approach to characterize and develop predictive assays for genes affecting tocochromanol variation in ba…
View article: Histological Analysis and 3D Reconstruction of Winter Cereal Crowns Recovering from Freezing: A Unique Response in Oat (Avena sativa L.)
Histological Analysis and 3D Reconstruction of Winter Cereal Crowns Recovering from Freezing: A Unique Response in Oat (Avena sativa L.) Open
The crown is the below ground portion of the stem of a grass which contains meristematic cells that give rise to new shoots and roots following winter. To better understand mechanisms of survival from freezing, a histological analysis was …
View article: Phytochemicals Attenuating Aberrant Activation of β-Catenin in Cancer Cells
Phytochemicals Attenuating Aberrant Activation of β-Catenin in Cancer Cells Open
Phytochemicals are a rich source of chemoprevention agents but their effects on modulating the Wnt/β-catenin signaling pathway have remained largely uninvestigated. Aberrantly activated Wnt signaling can result in the abnormal stabilizatio…
View article: Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase
Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase Open
The x-ray crystal structure of dimeric (+)-bornyl diphosphate synthase, a metal-requiring monoterpene cyclase from Salvia officinalis , is reported at 2.0-Å resolution. Each monomer contains two α-helical domains: the C-terminal domain cat…
View article: Monoterpene Synthases from Common Sage (Salvia officinalis )
Monoterpene Synthases from Common Sage (Salvia officinalis ) Open
Common sage (Salvia officinalis) produces an extremely broad range of cyclic monoterpenes bearing diverse carbon skeletons, including members of the p-menthane (1,8-cineole), pinane (alpha- and beta-pinene), thujane (isothujone), camphane …