Mitchell P. Christy
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View article: Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B
Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B Open
CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. CA-074 has been utilized in numerous studies to demonstrate the role of this protease in cellular and physiological functions. Cathepsin B in numerous human dis…
View article: Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions Open
Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein degradation, but in numerous human diseases, cathepsin B translocates to the cytosol having neutral pH where the enzyme activates inflammation a…
View article: Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2
Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2 Open
Three families of RNA viruses, the Coronaviridae, Flaviviridae, and Filoviridae, collectively have great potential to cause epidemic disease in human populations. The current SARS-CoV-2 (Coronaviridae) responsib…
View article: Synthesis of the 26-Membered Core of Thiopeptide Natural Products by Scalable Thiazole-Forming Reactions of Cysteine Derivatives and Nitriles
Synthesis of the 26-Membered Core of Thiopeptide Natural Products by Scalable Thiazole-Forming Reactions of Cysteine Derivatives and Nitriles Open
The increased resistance of bacteria to clinical antibiotics is one of the major dilemmas facing human health and without solutions the problem will grow exponentially worse. Thiopeptide natural products have shown promising antibiotic act…
View article: Global chemical effects of the microbiome include new bile-acid conjugations
Global chemical effects of the microbiome include new bile-acid conjugations Open
View article: Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids
Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids Open
A mosaic of cross-phyla chemical interactions occurs between all metazoans and their microbiomes. In humans, the gut harbors the heaviest microbial load, but many organs, particularly those with a mucosal surface, associate with highly ada…
View article: Total Synthesis and Anti-Cancer Activity of Micrococcin P1 and Synthetic Fragments
Total Synthesis and Anti-Cancer Activity of Micrococcin P1 and Synthetic Fragments Open
Thiopeptides are a versatile group of natural products with a wealth of therapeutic potential. To expand the methods of syntheses of these compounds and more closely study their in vitro activity, we report the total synthesis of micrococc…
View article: Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements
Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements Open
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of endogenous lipids with antidiabetic and anti-inflammatory activities. Interest in these lipids is due to their unique biological activites and the observa…
View article: Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State
Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State Open
Recently, the field of stem cell-based regeneration has turned its attention toward chemical approaches for controlling the pluripotency and differentiation of embryonic stem cells (ESCs) using drug-like small molecule modulators. Growth f…
View article: CCDC 1054026: Experimental Crystal Structure Determination
CCDC 1054026: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1054025: Experimental Crystal Structure Determination
CCDC 1054025: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …