Martin Wolf
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View article: Prime editing as a promising therapeutic strategy for junctional epidermolysis bullosa
Prime editing as a promising therapeutic strategy for junctional epidermolysis bullosa Open
Gene therapies offer new possibilities for the precise correction of monogenic disorders. Here, we present the first prime editing (PE)-based gene repair strategy for pathogenic COL17A1 variants that cause junctional epidermolysis bullosa …
View article: Two-layer dynamic blood phantom for assessing NIRS device accuracy
Two-layer dynamic blood phantom for assessing NIRS device accuracy Open
Near-infrared spectroscopy (NIRS) is a widely used non-invasive method for measuring oxygenation and hemodynamics. NIRS devices are validated using phantoms that accurately replicate the optical properties of human tissue. The aim was to d…
View article: Effects of contact with a dog on prefrontal brain activation in patients in a minimally conscious state: A controlled crossover trial
Effects of contact with a dog on prefrontal brain activation in patients in a minimally conscious state: A controlled crossover trial Open
The first studies have indicated that animal-assisted therapy benefits patients in a minimally conscious state (MCS), but the evidence is scarce. It is thus crucial to understand how these patients react to animal contact. This study aimed…
View article: Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction
Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction Open
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) constitute a promising therapy for myocardial infarction (MI). The lack of an effective immunosuppressive regimen, combined with single-cell transplantations, results i…
View article: Comparison of a conventional image processing approach with an artificial neural network approach to three‐dimensionally trace multiple particles in dynamic x‐ray microtomography experiments under laboratory conditions
Comparison of a conventional image processing approach with an artificial neural network approach to three‐dimensionally trace multiple particles in dynamic x‐ray microtomography experiments under laboratory conditions Open
This paper compares a classic digital image processing approach to trace particles in laboratory x‐ray micro‐computed tomography (µCT), which is based on a combination of random sample consensus (RANSAC) algorithm and least squares ellipse…
View article: STRAW-b (STRings for Absorption length in Water-b): the second pathfinder mission for the Pacific Ocean Neutrino Experiment
STRAW-b (STRings for Absorption length in Water-b): the second pathfinder mission for the Pacific Ocean Neutrino Experiment Open
Since 2018, the potential for a high-energy neutrino telescope, named the Pacific Ocean Neutrino Experiment (P-ONE), has been thoroughly examined by two pathfinder missions, STRAW and STRAW-b, short for STRAW and STRAW-b. The P-ONE project…
View article: A Close-in LiDAR for Diffusive Media based on a 32 × 32 CMOS SPAD Image Sensor
A Close-in LiDAR for Diffusive Media based on a 32 × 32 CMOS SPAD Image Sensor Open
The ability of light detection and ranging (LiDAR) systems to provide depth information of a scene is useful in various areas, including surgery and imaging within a medium. The challenge for LiDAR at certain wavelengths, due to the scatte…
View article: Column-Parallel Dynamic TDC Reallocation in SPAD Sensor Module Fabricated in 180nm CMOS for Near Infrared Optical Tomography
Column-Parallel Dynamic TDC Reallocation in SPAD Sensor Module Fabricated in 180nm CMOS for Near Infrared Optical Tomography Open
A major problem for optical biomedical imaging methods, e.g. near-infrared optical tomography (NIROT), using time resolved SPAD sensors is a slow acquisition time, resulting in motion artefacts and decreased patient comfort. We present a n…
View article: Development of A Micro-CT Scanner with Dual-Energy Option and Endovascular Contrast Agent Administration Protocol for Fetal and Neonatal Virtual Autopsy
Development of A Micro-CT Scanner with Dual-Energy Option and Endovascular Contrast Agent Administration Protocol for Fetal and Neonatal Virtual Autopsy Open
The rate of parental consent for fetal and perinatal autopsy is decreasing, whereas parents are more likely to agree to virtual autopsy by non-invasive imaging methods. Fetal and perinatal virtual autopsy needs high-resolution and good sof…
View article: Precision and normal values of cerebral blood volume in preterm neonates using time‐resolved near‐infrared spectroscopy
Precision and normal values of cerebral blood volume in preterm neonates using time‐resolved near‐infrared spectroscopy Open
Aim To investigate cerebral blood volume (CBV) in preterm neonates using time‐resolved near‐infrared spectroscopy. Methods In this prospective observational study, time‐resolved near‐infrared spectroscopy measurements of CBV using tNIRS‐1 …
View article: Time- and angle-resolved photoemission data of 1T-TaS2
Time- and angle-resolved photoemission data of 1T-TaS2 Open
Time- and angle-resolved photoemission spectroscopy data of bulk 1T-TaS2, acquired using the XUV trARPES setup at the Fritz-Haber-Institute of the Max-Planck Society, Berlin, Germany, and the UV trARPES setup at Stanford University, Califo…
View article: Time- and angle-resolved photoemission data of 1T-TaS2
Time- and angle-resolved photoemission data of 1T-TaS2 Open
Time- and angle-resolved photoemission spectroscopy data of bulk 1T-TaS2, acquired using the XUV trARPES setup at the Fritz-Haber-Institute of the Max-Planck Society, Berlin, Germany, and the UV trARPES setup at Stanford University, Califo…
View article: Two-layered blood-lipid phantom and method to determine absorption and oxygenation employing changes in moments of DTOFs
Two-layered blood-lipid phantom and method to determine absorption and oxygenation employing changes in moments of DTOFs Open
Near-infrared spectroscopy (NIRS) is an established technique for measuring tissue oxygen saturation (StO 2 ), which is of high clinical value. For tissues that have layered structures, it is challenging but clinically relevant to obtain S…
View article: Effects of contact with a dog on prefrontal brain activity: A controlled trial
Effects of contact with a dog on prefrontal brain activity: A controlled trial Open
Background There is a broad range of known effects of animal contact on human mental and physical health. Neurological correlates of human interaction with animals have been sparsely investigated. We investigated changes in frontal brain a…
View article: Resolution and penetration depth of reflection-mode time-domain near infrared optical tomography using a ToF SPAD camera
Resolution and penetration depth of reflection-mode time-domain near infrared optical tomography using a ToF SPAD camera Open
In a turbid medium such as biological tissue, near-infrared optical tomography (NIROT) can image the oxygenation, a highly relevant clinical parameter. To be an efficient diagnostic tool, NIROT has to have high spatial resolution and depth…
View article: The ways our hearts tick together – A vegetative hyperscanning study involving a self-paced interpersonal motor entrainment task
The ways our hearts tick together – A vegetative hyperscanning study involving a self-paced interpersonal motor entrainment task Open
Cardiac physiological synchrony between two persons is considered to be an important component of social interaction. Yet, the processes underlying physiological synchrony remain unclear. We aim to investigate these processes. 20 dyads (19…
View article: Optical imaging and spectroscopy for the study of the human brain: status report
Optical imaging and spectroscopy for the study of the human brain: status report Open
This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit of novel methods to explore brain health and function. While the first report focused on neurophotonic tools mostly appli…
View article: Systemic physiology augmented functional near-infrared spectroscopy: a powerful approach to study the embodied human brain
Systemic physiology augmented functional near-infrared spectroscopy: a powerful approach to study the embodied human brain Open
In this Outlook paper, we explain why an accurate physiological interpretation of functional near-infrared spectroscopy (fNIRS) neuroimaging signals is facilitated when systemic physiological activity (e.g., cardiorespiratory and autonomic…
View article: Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise
Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise Open
SIGNIFICANCE: Multi-laboratory initiatives are essential in performance assessment and standardization-crucial for bringing biophotonics to mature clinical use-to establish protocols and develop reference tissue phantoms that all will allo…
View article: Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography
Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography Open
Abnormal cerebral accumulation of amyloid-beta peptide (Aβ) is a major hallmark of Alzheimer’s disease. Non-invasive monitoring of Aβ deposits enables assessing the disease burden in patients and animal models mimicking aspects of the huma…
View article: Systemic physiology augmented functional near-infrared spectroscopy hyperscanning: a first evaluation investigating entrainment of spontaneous activity of brain and body physiology between subjects
Systemic physiology augmented functional near-infrared spectroscopy hyperscanning: a first evaluation investigating entrainment of spontaneous activity of brain and body physiology between subjects Open
Significance: Functional near-infrared spectroscopy (fNIRS) enables measuring the brain activity of two subjects while they interact, i.e., the hyperscanning approach. Aim: In our exploratory study, we extended classical fNIRS hyperscannin…
View article: Time-resolved ARPES RAW data of bulk WSe2 for a quantitative comparison of time-of-flight momentum microscopes and hemispherical analyzers: RAW MM data
Time-resolved ARPES RAW data of bulk WSe2 for a quantitative comparison of time-of-flight momentum microscopes and hemispherical analyzers: RAW MM data Open
Time- and angle-resolved photoemission spectroscopy data of bulk WSe2 using a laser-based XUV source and a time-of-flight momentum microscope analyzer. The dataset here comprises part of the machine RAW data used to construct the processed…
View article: Time-resolved ARPES RAW data of bulk WSe2 for a quantitative comparison of time-of-flight momentum microscopes and hemispherical analyzers: RAW MM data
Time-resolved ARPES RAW data of bulk WSe2 for a quantitative comparison of time-of-flight momentum microscopes and hemispherical analyzers: RAW MM data Open
Time- and angle-resolved photoemission spectroscopy data of bulk WSe2 using a laser-based XUV source and a time-of-flight momentum microscope analyzer. The dataset here comprises part of the machine RAW data used to construct the processed…
View article: 2.5 Hz sample rate time-domain near-infrared optical tomography based on SPAD-camera image tissue hemodynamics
2.5 Hz sample rate time-domain near-infrared optical tomography based on SPAD-camera image tissue hemodynamics Open
Time-domain near-infrared optical tomography (TD NIROT) techniques based on diffuse light were gaining performance over the last years. They are capable of imaging tissue at several centimeters depth and reveal clinically relevant informat…