Mithil Soni
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View article: Assessing removal force of abutment in dental implants: An in vitro study
Assessing removal force of abutment in dental implants: An in vitro study Open
The removal force of abutments with various implant abutment connections is of interest. Hence, thirty implants were categorized into types, i.e., external hex, internal hex and conical connections. The highest removal force was recorded i…
View article: Evaluation of plaque removal effectiveness of a microcurrent-emitting toothbrush among patients with fixed orthodontic appliances
Evaluation of plaque removal effectiveness of a microcurrent-emitting toothbrush among patients with fixed orthodontic appliances Open
The effect of a microcurrent-emitting toothbrush (MCT) versus a conventional toothbrush (CT) in 40 orthodontic patients is of interest. The MCT significantly reduced plaque levels (mean difference: 8.2%, p<0.001) and improved gingival heal…
View article: Effect of Bleaching Agents on the Bond Strength of Orthodontic Brackets
Effect of Bleaching Agents on the Bond Strength of Orthodontic Brackets Open
A BSTRACT Background: One common technique for tooth whitening is the use of bleaching chemicals, which is often done either before or during orthodontic treatment. The impact of these chemicals on the binding strength of orthodontic brack…
View article: The Effect of Various Implant Coatings on Bone Formation and Cell Adhesion-In Vitro Study
The Effect of Various Implant Coatings on Bone Formation and Cell Adhesion-In Vitro Study Open
A BSTRACT Background: Implant coatings play a crucial role in enhancing bone-implant integration and cellular adhesion. Despite numerous advancements in surface modifications, the comparative effect of various coatings on bone formation an…
View article: The prospect of universal coronavirus immunity: characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses
The prospect of universal coronavirus immunity: characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses Open
T cell immunity plays a central role in clinical outcomes of Coronavirus Infectious Disease 2019 (COVID-19) and T cell-focused vaccination or cellular immunotherapy might provide enhanced protection for some immunocompromised patients. Pre…
View article: Case Report: Kinetics and durability of humoral and cellular response of SARS-CoV-2 messenger RNA vaccine in a lung and kidney transplant recipient
Case Report: Kinetics and durability of humoral and cellular response of SARS-CoV-2 messenger RNA vaccine in a lung and kidney transplant recipient Open
We present a case report of a 63-year-old female health care worker who is 15 years status post double lung transplant and six years status post living related donor kidney transplant who is healthy on a chronic immunosuppression regimen i…
View article: Supplementary Data from Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer
Supplementary Data from Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer Open
Figure S1. miR-489 modulates autophagy. Figure S2. Western blot analysis of autophagy flux in breast cancers. Figure S3. Validation of microarray using real-time RT-PCR analysis. Figure S4. miR-489 restoration in HCC1954 and T47D cells und…
View article: Supplementary Data from Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer
Supplementary Data from Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer Open
Figure S1. miR-489 modulates autophagy. Figure S2. Western blot analysis of autophagy flux in breast cancers. Figure S3. Validation of microarray using real-time RT-PCR analysis. Figure S4. miR-489 restoration in HCC1954 and T47D cells und…
View article: Data from Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer
Data from Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer Open
It is postulated that the complexity and heterogeneity in cancer may hinder most efforts that target a single pathway. Thus, discovery of novel therapeutic agents targeting multiple pathways, such as miRNAs, holds promise for future cancer…
View article: Data from Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer
Data from Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer Open
It is postulated that the complexity and heterogeneity in cancer may hinder most efforts that target a single pathway. Thus, discovery of novel therapeutic agents targeting multiple pathways, such as miRNAs, holds promise for future cancer…
View article: Supplementary Table S2 from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Supplementary Table S2 from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Supplementary Table S2 shows the clinicopathological characteristics of clinical samples.
View article: Supplementary Tables from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Supplementary Tables from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Supplementary Tables - Supplementary Tables S1, S3 and S4. S1 shows frequency of CSCs after transplantation of the indicated cells. S3 shows multivariate Cox regression data. S4 Positive correlation between IL-1α and HER2 or IL6 expression…
View article: Supplementary Figures from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Supplementary Figures from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Supplementary Figures with legends- Supplementary Figures S1 to S14. S1. Shows gene ontology enrichment analysis between MCF10A-HER2 and MCF10A-vector cells. S2 shows western blot analysis of HER2 signaling after IL-1β treatment. S3, S4 an…
View article: Supplementary Figures from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Supplementary Figures from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Supplementary Figures with legends- Supplementary Figures S1 to S14. S1. Shows gene ontology enrichment analysis between MCF10A-HER2 and MCF10A-vector cells. S2 shows western blot analysis of HER2 signaling after IL-1β treatment. S3, S4 an…
View article: Supplementary Table S2 from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Supplementary Table S2 from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Supplementary Table S2 shows the clinicopathological characteristics of clinical samples.
View article: Data from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Data from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Systemic inflammation in breast cancer correlates with poor prognosis, but the molecular underpinnings of this connection are not well understood. In this study, we explored the relationship between HER2 overexpression, inflammation, and e…
View article: Supplementary Tables from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Supplementary Tables from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Supplementary Tables - Supplementary Tables S1, S3 and S4. S1 shows frequency of CSCs after transplantation of the indicated cells. S3 shows multivariate Cox regression data. S4 Positive correlation between IL-1α and HER2 or IL6 expression…
View article: Supplementary Methods and References from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Supplementary Methods and References from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Supplementary methods and References - Supplementary methods describing key reagents, plasmids, cell culture, CRISP/Cas9 system, HER2 agonist preparation, RT-PCR, western blot, flow-cytometry, tumorsphere culture, ChIP assay, animal experi…
View article: Data from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Data from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Systemic inflammation in breast cancer correlates with poor prognosis, but the molecular underpinnings of this connection are not well understood. In this study, we explored the relationship between HER2 overexpression, inflammation, and e…
View article: Supplementary Methods and References from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance
Supplementary Methods and References from HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance Open
Supplementary methods and References - Supplementary methods describing key reagents, plasmids, cell culture, CRISP/Cas9 system, HER2 agonist preparation, RT-PCR, western blot, flow-cytometry, tumorsphere culture, ChIP assay, animal experi…
View article: The prospect of universal coronavirus immunity: a characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses
The prospect of universal coronavirus immunity: a characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses Open
T cell immunity plays a central role in clinical outcomes of Coronavirus Infectious Disease 2019 (COVID-19). Therefore, T cell-focused vaccination or cellular immunotherapy might provide enhanced protection for immunocompromised patients. …
View article: miR-489 Confines Uncontrolled Estrogen Signaling through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer
miR-489 Confines Uncontrolled Estrogen Signaling through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer Open
Approximately 75% of diagnosed breast cancer tumors are estrogen-receptor-positive tumors and are associated with a better prognosis due to response to hormonal therapies. However, around 40% of patients relapse after hormonal therapies. G…
View article: miR-489 Confines Uncontrolled Estrogen Signaling Through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer
miR-489 Confines Uncontrolled Estrogen Signaling Through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer Open
Background: Approximately 75% of diagnosed breast cancer tumors are estrogen-receptor (ER) positive tumors and are associated with better prognosis due to their response to hormonal therapies. However, around 40% of patients relapse after …
View article: TGM4: an immunogenic prostate-restricted antigen
TGM4: an immunogenic prostate-restricted antigen Open
Background Prostate cancer is the second leading cause of cancer-related death in men in the USA; death occurs when patients progress to metastatic castration-resistant prostate cancer (CRPC). Although immunotherapy with the Food and Drug …
View article: miR-489 confines uncontrolled estrogen signaling through a negative feedback mechanism and regulates tamoxifen resistance in breast cancer
miR-489 confines uncontrolled estrogen signaling through a negative feedback mechanism and regulates tamoxifen resistance in breast cancer Open
Background Approximately 75% of diagnosed breast cancer tumors are Estrogen receptor (ER) positive tumors and are associated with better prognosis due to their response to hormonal therapies. However, around 40% of patients relapse after h…
View article: 168 A novel prostate-restricted tumor-associated antigen: a potential therapeutic target
168 A novel prostate-restricted tumor-associated antigen: a potential therapeutic target Open
Background Prostate cancer is the second leading cause of cancer related death in men in the United States, mainly due to disease progression to metastatic castration-resistant prostate cancer (mCRPC). Although immunological treatment with…
View article: Identification of microRNAs as New Blood Biomarkers to Predict Breast Cancer Recurrence
Identification of microRNAs as New Blood Biomarkers to Predict Breast Cancer Recurrence Open
MicroRNAs (microRNAs) are short sequences of RNA (about 22 nucleotides) that are involved in the regulation of gene expression.Previous studies have suggested that a number of microRNAs are recognized as new biomarkers for cancers.The aim …